A multifunctional streptococcal collagen-mimetic protein coating prevents bacterial adhesion and promotes osteoid formation on titanium

Bronk, Julianna; Russell, Brooke; Rivera, José Julián; Pasqualini, Renata; Arap, Wadih; Höök, Magnus; Barbu, E. Magda

doi:10.1016/j.actbio.2014.04.005

Cited by 42 publications

(25 citation statements)

References 47 publications

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“…Engineered, collagen-mimetic peptide implant coatings have been used in place of human collagen I to limit bacterial adhesion and colonization while still providing osteoinductive cues. [58] The collagen mimic was engineered to include specific ligand sequences that recognize highly expressed integrins on osteogenic cells. The coatings were adhesive for multiple osteogenic cell types with a similar level of adhesion as found on human collagen I coatings.…”

Section: Challenges and Potential Solutions For Osseointegrationmentioning

confidence: 99%

Multifunctional coatings to simultaneously promote osseointegration and prevent infection of orthopaedic implants

et al. 2016

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The two leading causes of failure for joint arthroplasty prostheses are aseptic loosening and periprosthetic joint infection. With the number of primary and revision joint replacement surgeries on the rise, strategies to mitigate these failure modes have become increasingly important. Much of the recent work in this field has focused on the design of coatings either to prevent infection while ignoring bone mineralization or vice versa, to promote osseointegration while ignoring microbial susceptibility. However, both coating functions are required to achieve long-term success of the implant; therefore, these two modalities must be evaluated in parallel during the development of new orthopaedic coating strategies. In this review, we discuss recent progress and future directions for the design of multifunctional orthopaedic coatings that can inhibit microbial cells while still promoting osseointegration.

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Section: Challenges and Potential Solutions For Osseointegrationmentioning

confidence: 99%

Multifunctional coatings to simultaneously promote osseointegration and prevent infection of orthopaedic implants

et al. 2016

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“…5 Some of the most studied methods comprise finishing implant material surfaces with repellent coatings, antimicrobials, surfactants and hydroxyapatites. [6][7][8][9] These strategies, however, are transient (e.g. surface-incorporated antimicrobials are subjected to depletion).…”

Section: Introductionmentioning

confidence: 99%

Antibiofilm activity of sandblasted and laser-modified titanium against microorganisms isolated from peri-implantitis lesions

Drago

Bortolin

Vecchi

et al. 2016

Journal of Chemotherapy

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Infections due to biofilm-producing microorganisms are one of the main causes for the failure of dental implants. Increasing efforts have been made in order to develop new strategies to prevent biofilm formation. In this study, the biofilm development on a newly designed laser-modified titanium implant surface was evaluated and compared to that on conventional sandblasted titanium used in implant dentistry. The amount of biofilm produced by Staphylococcus aureus, Pseudomonas aeruginosa and Porphyromonas gingivalis isolated from peri-implantitis was assessed by a semi-quantitative spectrophotometric method and by confocal laser scanning microscopy. Results showed a lower biofilm production on laser-modified surface compared to the sandblasted one. In particular, a significantly lower total volume of the biomass was observed on laser-modified surface, while no significant changes in live/dead bacteria percentages were noticed between materials. Modifying the topography of the conventional implant surface with laser ablation could represent a promising approach for inhibiting biofilm formation.

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“…This passive antimicrobial coating resisted hydrolytic and mechanical challenges and exhibited no significant release of peptides from the modified titanium surface. A multifunctional streptococcal collagen-mimetic protein coating reduced the bacterial adherence of S. aureus and S. epidermidis 158) . Although AMPs show a low tendency to induce resistances, more and more naturally occurring human AMPs lose their antimicrobial effectiveness against various bacterial strains.…”

Section: Antimicrobial Peptide Surfacesmentioning

confidence: 99%

Antimicrobial dental implant functionalization strategies —A systematic review

Grischke

Eberhard

Stiesch

2016

Dental Materials Journal

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A multifunctional streptococcal collagen-mimetic protein coating prevents bacterial adhesion and promotes osteoid formation on titanium

Cited by 42 publications

References 47 publications

Multifunctional coatings to simultaneously promote osseointegration and prevent infection of orthopaedic implants

Multifunctional coatings to simultaneously promote osseointegration and prevent infection of orthopaedic implants

Antibiofilm activity of sandblasted and laser-modified titanium against microorganisms isolated from peri-implantitis lesions

Antimicrobial dental implant functionalization strategies —A systematic review

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