“…Of interest, TDP-43 binds to miRNAs and components of the miRNA-processing pathway at different steps, exhibiting direct interactions with mature miRNAs, nuclear pri-miRNAs, the nuclear RNAse Drosha, and the cytoplasmic RNAse Dicer (Buratti et al, 2010; Emde et al, 2015; Kawahara and Mieda-Sato, 2012; King et al, 2014; Li et al, 2013b; Zhang et al, 2013). In addition, TDP-43 also affects how miR-206, a skeletal muscle-specific miRNA involved in neuromuscular junction re-innervation in ALS animal models and following nerve injury, incorporates into the RISC (King et al, 2014). Our data suggests that TDP-43, in part, may regulate the function of miRNAs decreased in sALS spinal cord as well as their downstream targets, perhaps by the sequestration of miRNA biogenesis components to stress granules upon stress (Emde et al, 2015).…”