Clinical characteristics of second primary cancer in colorectal cancer patients: the impact of colorectal cancer or other second cancer occurring first

Sun, Lulu; Tai, Yi-Yun; Liao, Su-Mien; Lin, Tang-Yu; Shih, Yuh-Chuan; Chang, Se-Fen; Huang, Ching‐Wen; Chan, Hon-Man; Huang, Che-Jen; Wang, Jaw‐Yuan

doi:10.1186/1477-7819-12-73

Cited by 13 publications

(5 citation statements)

References 16 publications

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“…For example, oncofactors released by colon cancer cells would give metachronous metastases if uptaken and expressed by fibroblasts in the liver (CK7 − /CK20 + /CDX2 + ) or a second type of cancer such as a cholangiocarcinoma (upper gastrointestinal tract and CK7 + /CK20 − /CDX2 − ) if they were uptaken and expressed by epithelial liver cells 22,35 . The clinical evidence that second primary cancers usually express a CK7/CK20 pattern opposite to the first primary seems to justify the legitimacy of this hypothesis 36,37 . It must be mentioned that the in vitro transformation of BRCA1 KO fibroblasts is not supported by evidence that synchronous or metachronous metastases can occur in fibroblasts, in vivo .…”

Section: Discussionmentioning

confidence: 99%

Oncosuppressor-Mutated Cells as a Liquid Biopsy Test for Cancer-Screening

Abdouh

Gao

Arena

et al. 2019

Sci Rep

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We reported on the ability of immortalized or oncosuppressor-mutated cells (OMCs) to uptake circulating cancer-factors and give tumors when transplanted into mice. This led to the first biological based liquid biopsy test, which we called MATER-D platform. In the present study, we showed for the first time that a different type of OMCs (PTEN-deficient human epithelial MCF10A cells) turn malignant when exposed to cancer patient’s sera, confirming the concept that different cells with diverse oncosuppressor mutations can uptake cancer factors and be used in biological based liquid biopsy tests. Our observations were confirmed in a large variety of solid and haematological malignancies. This test was able to detect dysplasia and carcinomas in situ lesions in different organs and circulating factors in cancer patients years after the removal of their lesions. To our knowledge, this ability is unique and not shared by other liquid biopsy platforms. Immunohistochemistry analysis of the xenotransplants revealed identical patterns of differentiation regardless of the cancer type, showing that differentiation through horizontal transfer might be dependent on the nature of the target cells rather than the type of cancer factors. These data strengthen the notion that OMC-based liquid biopsy tests might be promising platforms for cancer screening.

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Section: Discussionmentioning

confidence: 99%

Oncosuppressor-Mutated Cells as a Liquid Biopsy Test for Cancer-Screening

Abdouh

Gao

Arena

et al. 2019

Sci Rep

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“…It was well established that the biological characteristics and prognosis were different between colon cancer (CC) and rectal cancer (RC) [ 13 ]. However, most of current studies evaluated risk of SPMs by considering CC and RC as the same condition, which might generate some misunderstandings of results [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

The Incidence Characteristics of Second Primary Malignancy after Diagnosis of Primary Colon and Rectal Cancer: A Population Based Study

et al. 2015

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BackgroundWith the expanding population of colorectal cancer (CRC) survivors in the United States, one concerning issue is the risk of developing second primary malignancies (SPMs) for these CRC survivors. The present study attempts to identify the incidence characteristics of SPMs after diagnosis of first primary colon cancer (CC) and rectal cancer (RC).Methods189,890 CC and 83,802 RC cases were identified from Surveillance, Epidemiology and End Results Program (SEER) database. We performed rate analysis on incidence trend of SPMs in both CC and RC. Expected incidence rates were stratified by age, race and stage, calendar year of first CRC diagnosis and latency period since first CRC diagnosis. The standardized incidence ratios (SIRs), measure for estimating risk of SPMs, were calculated for CC and RC respectively.ResultsThe trends of incidence of SPMs in both CC and RC were decreasing from 1992 to 2012. Both CC and RC survivors had higher risk of developing SPMs (SIRCC = 1.13; SIRRC = 1.05). For CC patients, the highest risks of SPM were cancers of small intestine (SIR = 4.03), colon (SIR = 1.87) and rectum (SIR = 1.80). For RC patients, the highest risks of SPMs were cancers of rectum (SIR = 2.88), small intestine (SIR = 2.16) and thyroid (SIR = 1.46). According to stratified analyses, we also identified incidence characteristics which were contributed to higher risk of developing SPMs, including the age between 20 and 40, American Indian/Alaska Native, localized stage, diagnosed at calendar year from 2002 to 2012 and the latency between 12 and 59 months.ConclusionsBoth CC and RC survivors remain at higher risk of developing SPMs. The identification of incidence characteristics of SPMs is extremely essential for continuous cancer surveillance among CRC survivors.

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“…In patients with GC, the most common SPC is CRC, followed by lung cancer (5)(6)(7)9,13,14). The high incidence of CRC in GC patients may be attributed to the genetic and environmental factors.…”

Section: Discussionmentioning

confidence: 99%

“…Synchronous MPC was defined as those with an interval within 6 months. On the other hand, metachronous MPC are defined as those with an interval of more than 6 months (8)(9)(10). In this study, we report a metachronous MPC, as the colorectal cancer (CRC) which was diagnosed 49 months later after the diagnosis of GC.…”

Section: Introductionmentioning

confidence: 96%

Laparoscopic radical resection of gastric cancer and metachronous colon cancer—a case report

Jiang¹,

Mao²,

Wu³

et al. 2020

Transl Cancer Res TCR

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Due to the favorable prognosis of gastric cancer (GC), the incidence of second primary cancer (SPC) accompanied with GC has increased. Here, we reported a case of a 69-year-old male patient with metachronous GC and colon cancer, who had undergone laparoscopic radical resection of distal GC 4 years ago. During this hospitalization, the patient underwent laparoscopic radical resection of left hemicolectomy for metachronous colon cancer. Few literatures have reported that patients with metachronous GC and colon cancer can receive laparoscopic surgery successfully. The patient recovered well and was discharged on day 10 post-operation. The pathologic specimen was identified as metachronous colon cancer. We concluded that GC patients need regular standard follow-up programs after undergoing operations. For multiple primary cancers (MPCs), treatments need to be individualized and comprehensive. Laparoscopic surgery is recommended as an appropriate option.

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Clinical characteristics of second primary cancer in colorectal cancer patients: the impact of colorectal cancer or other second cancer occurring first

Cited by 13 publications

References 16 publications

Oncosuppressor-Mutated Cells as a Liquid Biopsy Test for Cancer-Screening

Oncosuppressor-Mutated Cells as a Liquid Biopsy Test for Cancer-Screening

The Incidence Characteristics of Second Primary Malignancy after Diagnosis of Primary Colon and Rectal Cancer: A Population Based Study

Laparoscopic radical resection of gastric cancer and metachronous colon cancer—a case report

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