Context: Lip position has become one of the most important soft-tissue analyses as it influences the occlusion, tooth stability, and facial esthetics. Sagittal lip position may vary in different skeletal malocclusions which can be evaluated by various reference lines. Aims and Objectives: The aims of this study were to compare the sagittal lip positions in different skeletal malocclusions in Nalgonda population and with other reported populations. Materials and Methods: The sample consisted of 180 (90 males and 90 females) adult subjects from Nalgonda, population visiting Kamineni Institute of Dental Sciences and Hospital. The age range of the sample chosen was between 18 to 26 years. Lateral cephalometric radiographs of subjects were taken in natural head position. Radiographs were manually traced and five reference lines such as Sushner, Steiner, Burstone, Holdaway, and Ricketts were used. The linear distance between the tip of the lips and the five reference lines were measured. Post hoc Tukey's test was used for comparison of the mean cephalometric values of three skeletal malocclusions. Results: The findings showed a significant difference in the sagittal lip positions in different skeletal malocclusions (P < 0.05). Conclusion: (1) Upper lip (UL) and lower lip (LL) in skeletal Class I group are protrusive than norms on all reference lines. (2) Skeletal Class II group has the most protrusive UL and LL in comparison to skeletal Class I and Class III on all the reference lines. (3) Skeletal Class III group has the most protrusive LL in comparison to skeletal Class II and Class I on all reference lines.