Association of LOX-1 gene polymorphisms with cerebral infarction in northern Chinese Han population

Abstract

BackgroundLectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) plays an important role in the pathophysiology of atherosclerosis and thrombosis. This study is aimed at evaluating the potential association of 3’-UTR-C188T and G501C in LOX-1 gene with cerebral infarction.MethodsA total of 386 patients with cerebral infarction and 386 healthy controls were included in the study, which were unrelated Chinese Han population in the Liaoning Province of northern China. The single nucleotide polymorphisms, 3’-UTR-C188T and G501C, were analyzed by polymerase chain reaction–ligation detection reaction method.ResultsThe frequencies of CC + GC genotype, GC genotype and C allele of G501C in the patients with cerebral infarction were significantly higher than those in the controls (P < 0.01, P < 0.01, P = 0.04, respectively). The correlation still remained after adjusting for confounding risk factors of cerebral infarction. In addition, no significant association was observed between 3’-UTR-C188T and cerebral infarction.ConclusionsThe study indicated that the G501C variant in LOX-1 gene may be associated with susceptibility to cerebral infarction, independent of other common risk factors, in northern Chinese Han population.

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“…As the most common type of stroke, CI accounts for about 43.7-78.9 % of all strokes in China and CI is a complex disease with both genetic and environmental factors [2]. The pathological basis of CI is involved in the disrupted blood supply in the brain, ischemia and hypoxia causing cerebral malacia and ischemic necrosis in brain tissues [3].…”

The Influence of OLR1 and PCSK9 Gene Polymorphisms on Ischemic Stroke: Evidence from a Meta-Analysis

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“…Liu et al found that the frequencies of CC ? GC genotype, GC genotype and C allele of G501C in patients with cerebral infarction were significantly higher than those in the controls [24]. Brinkley et al have shown that variation in the LOX-1 3 0 UTR188C/T and K167N (G501C) polymorphisms were associated with plasma-soluble LOX-1 levels in older men and women in the USA [5].…”