LOX-1 gene variants and maternal levels of plasma oxidized LDL and malondialdehyde in patients with gestational diabetes mellitus

Abstract

According to our results, ox-LDL and MDA levels were increased in GDM pregnant women and healthy pregnant women either with or without combined TT/NN genotype carriers, for our Turkish sample, these genotype carriers appear to be related with increased oxidative stress in patients with GDM.

Variations of malondialdehyde in pre-eclampsia

“…The aims of this communication are to provide some evidence to support our claim and to point out a number of technical problems associated with the production, consumption, and analysis of MDA in biological samples. In most of the clinical investigations published in medical journals, including recent works (1-4), simple spectrophotometric analysis (1) or liquid chromatographic analysis (2) of a thiobarbitoric acid (TBA) adduct of MDA as a biomarker of oxidative stress was carried out (19). Despite the wide applications of spectroscopic or chromatographic methods, there were insufficient validation data in the literature.…”

The role of CXC chemokine ligand 16 in physiological and pathological pregnancies

“…In addition, increases in the plasma CXCL16 level were closely associated with an increased level of low‐density lipoprotein cholesterol (LDL‐C). LDL‐C is closely associated with oxLDL, and current studies have also confirmed that the level of oxLDL increases in patients with GDM . Sánchez‐Vera et al observed an increased LDL susceptibility to oxidation, whereas Bonet et al demonstrated that oxLDL is cytotoxic to placental cells.…”

“…LDL-C is closely associated with oxLDL, and current studies have also confirmed that the level of oxLDL increases in patients with GDM. [109][110][111][112] Sánchez-Vera et al 113 that CXCL16 is essential for the podocyte uptake of oxLDL as a scavenger receptor. Furthermore, they also observed that oxLDL could induce an increase in the expression of CXCL16 in renal podocytes.…”

Placental Related Disorders of Pregnancy

“…Elevated maternal plasma levels at 28 WOG [292] Oxidized DNA DNA is vulnerable to oxidation and undergoes a continuous cycle of damage and repair in living cells.…”