First-trimester prediction of small-for-gestational age neonates incorporating fetal Doppler parameters and maternal characteristics

Seravalli, Viola; Block-Abraham, Dana; Turan, Özhan; Doyle, L. Austin; Kopelman, Jerome; Atlas, Robert; Jenkins, Chuka; Blitzer, Miriam G.; Baschat, Ahmet

doi:10.1016/j.ajog.2014.03.022

Cited by 14 publications

(11 citation statements)

References 24 publications

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“…Furthermore, diagnosis is primarily based on the projection of ultrasound estimation of FW during the second and third trimester at term [10]. Approaches for early prediction have included the assessment of clinical risk factors, ultrasound findings and the use of serum biomarkers, but until now, early antenatal detection of the IUGR and macrosomic fetuses have been inadequate [16,21,22,23,24,25]. …”

Section: Introductionmentioning

confidence: 99%

Correlation between Maternal Characteristics during Early Pregnancy, Fetal Growth Rate and Newborn Weight in Healthy Pregnancies

Caradeux

Serra²,

Palmeiro³

et al. 2016

Gynecol Obstet Invest

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Background: The objective of this study was to evaluate the association between maternal characteristics in early pregnancy and fetal growth (FG) and birth weight (BW). Methods: A prospective cohort study was performed in unselected pregnant women who attended an ultrasound evaluation at 11-14 weeks of pregnancy. Medical history, biochemical blood tests, biophysical variables and fetal weight at 20-25 and 30-36 weeks as well as the BW were assessed. Bivariate and multivariate linear models were constructed. Results: In all, 543 patients with normal pregnancy and labor were selected. The multiple regression analysis showed a statistically significant association between maternal body mass index (BMI) in early pregnancy and the uterine artery pulsatility index (UtAPI) in the first trimester with BW (p < 0.0008) and with the ratio of fetal growth between the second and third trimesters (p < 0.0001). No correlation was found between these variables and first trimester levels of hemoglobin or glycemia. Conclusion: Maternal first trimester BMI and UtAPI correlate with the rate of intrauterine FG and with the BW. This evidence highlights the influence of maternal first trimester variables on fetuses with normal growth and the potential role of these variables in fetal programming.

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Section: Introductionmentioning

confidence: 99%

Correlation between Maternal Characteristics during Early Pregnancy, Fetal Growth Rate and Newborn Weight in Healthy Pregnancies

Caradeux

Serra²,

Palmeiro³

et al. 2016

Gynecol Obstet Invest

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show abstract

“…First‐trimester prediction of SGA was previously investigated in a prospective study enrolling singleton pregnancies between 11 and 14 weeks . This is a secondary analysis of those patients who had a follow‐up second‐trimester ultrasound examination at one of the four study centers, between 18 and 22 weeks of gestation.…”

Section: Methodsmentioning

confidence: 99%

“…First-trimester prediction of SGA was previously investigated in a prospective study enrolling singleton pregnancies between 11 and 14 weeks. 8 This is a secondary analysis of those patients who had a follow-up second-trimester ultrasound examination at one of the four study centers, between 18 and 22 weeks of gestation. The original study protocol was approved by the Institutional Review Boards of the University of Maryland School of Medicine, Mercy Medical Center, and the Medstar Research Institute.…”

Section: Methodsmentioning

confidence: 99%

“…In the first trimester, high resistance blood flow patterns are common in the uteroplacental circulation, and accordingly, uterine and umbilical artery (UA) Doppler screening in isolation does not achieve risk stratification precise enough for uniform application . Although additional consideration of maternal characteristics and serum biomarkers improves first‐trimester screening performance for subsequent delivery of a small‐for‐gestational‐age (SGA) infant, sensitivity and specificity remain low . These findings suggest that placental dysfunction that is destined to evolution to fetal growth delay cannot be clinically discriminated in the first trimester.…”

Section: Introductionmentioning

confidence: 99%

“…[3][4][5][6] Although additional consideration of maternal characteristics and serum biomarkers improves first-trimester screening performance for subsequent delivery of a small-for-gestational-age (SGA) infant, sensitivity and specificity remain low. 7,8 These findings suggest that placental dysfunction that is destined to evolution to fetal growth delay cannot be clinically discriminated in the first trimester. After the first-trimester screen, the detailed second-trimester anatomic is the next point of contact at which screening for SGA could be readily incorporated into the existing prenatal care structure.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Second‐trimester prediction of delivery of a small‐for‐gestational‐age neonate: integrating sequential Doppler information, fetal biometry, and maternal characteristics

et al. 2014

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Biophysical markers for abnormal placentation: first and/or second trimester

Farina¹

2014

Prenatal Diagnosis

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Placental development is a major cause of a successful pregnancy, and in the presence of placental dysfunction, there is a higher risk of pregnancy complications. Doppler technology can be used for screening and detecting the more common pregnancy-associated diseases like preeclampsia, intrauterine growth retardation, and perinatal loss. In this review, the biophysical markers are discussed in the light of the latest information that appeared in the medical literature.

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First-trimester prediction of small-for-gestational age neonates incorporating fetal Doppler parameters and maternal characteristics

Cited by 14 publications

References 24 publications

Correlation between Maternal Characteristics during Early Pregnancy, Fetal Growth Rate and Newborn Weight in Healthy Pregnancies

Correlation between Maternal Characteristics during Early Pregnancy, Fetal Growth Rate and Newborn Weight in Healthy Pregnancies

Second‐trimester prediction of delivery of a small‐for‐gestational‐age neonate: integrating sequential Doppler information, fetal biometry, and maternal characteristics

Biophysical markers for abnormal placentation: first and/or second trimester

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