Correlation between Maternal Characteristics during Early Pregnancy, Fetal Growth Rate and Newborn Weight in Healthy Pregnancies

Caradeux, Javier; Serra, Ramón; Palmeiro, Yasna; Corréa, P; Valenzuela, Ignacio; Olguin, Jaime; Montenegro, Lazaro; Nien, Jyh Kae; Osorio, Eduardo; Illanes, Sebastián E.

doi:10.1159/000441786

Cited by 4 publications

(4 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Prepregnancy BMI had a positive association with the slope of EFW but not fetal head circumference, an index of early brain growth. While far from definitive, maternal prepregnancy or pregnancy BMI has been associated with greater fetal physical or head size in women with obesity compared with women with reference weight, 1 , 35 , 36 broadly consistent with our findings. In the neonatal period, prepregnancy BMI was associated with greater local thalamic connectivity and lower frontothalamic connectivity.…”

Section: Discussionsupporting

confidence: 89%

Association of Maternal Prepregnancy Body Mass Index With Fetal Growth and Neonatal Thalamic Brain Connectivity Among Adolescent and Young Women

Spann

Scheinost

Feng³

et al. 2020

JAMA Netw Open

View full text Add to dashboard Cite

Key Points Question Is maternal prepregnancy body mass index among adolescent and young women associated with fetal growth and neonatal functional connectivity? Findings In this cohort study that included 129 pregnant adolescent and young adult women, maternal prepregnancy body mass index had a significant positive association with the slope of estimated fetal weight and with greater local thalamic and lower frontothalamic connectivity. Meaning These findings suggest that maternal prepregnancy body mass index was associated with the regulation of body weight and functional connectivity of the thalamus in newborn infants.

show abstract

Section: Discussionsupporting

confidence: 89%

Association of Maternal Prepregnancy Body Mass Index With Fetal Growth and Neonatal Thalamic Brain Connectivity Among Adolescent and Young Women

Spann

Scheinost

Feng³

et al. 2020

JAMA Netw Open

View full text Add to dashboard Cite

show abstract

“…The adjusted model additionally included maternal age, parity, education level, pre‐pregnancy BMI, smoking and alcohol consumption during pregnancy and total energy intake. 4 , 5 , 6 , 7 , 44 , 45 , 46 , 47 These possible confounders were selected based on associations with exposure and outcomes in the existing literature. As previous analyses in the same cohort did not show any differences in metabolite concentrations between boys and girls, 35 and including infant sex in the models did not change the effect estimates, we did not include this factor in our models.…”

Section: Methodsmentioning

confidence: 99%

“… 1 , 2 , 3 Adverse maternal lifestyle and metabolic factors such as poor diet quality, a high total energy intake, inadequate macro‐ and micronutrient intake, and underweight and obesity, adversely affect the intrauterine environment and foetal nutrient availability for foetal growth and development, leading to increased risks of pre‐term birth, SGA and LGA. 4 , 5 , 6 , 7 Adaptations in maternal and foetal metabolic pathways underlie at least part of the associations between adverse maternal factors and pre‐term birth, SGA and LGA. Thus far, studies mainly focused on conventional biomarkers of metabolic status, such as glucose, insulin and lipid concentrations.…”

Section: Introductionmentioning

confidence: 99%

Associations of maternal and infant metabolite profiles with foetal growth and the odds of adverse birth outcomes

et al. 2021

View full text Add to dashboard Cite

Background: Adaptations in maternal and foetal metabolic pathways may predispose to altered foetal growth and adverse birth outcomes.Objective: To assess the associations of maternal early-pregnancy metabolite profiles and infant metabolite profiles at birth with foetal growth from first trimester onwards and the odds of adverse birth outcomes.Methods: In a prospective population-based cohort among 976 Dutch pregnant women and their children, serum concentrations of amino acids, non-esterified fatty acids (NEFA), phospholipids (PL) and carnitines in maternal early-pregnancy blood and in cord blood were obtained by liquid-chromatography tandem mass spectrometry. Information on foetal growth was available from first trimester onwards.Results: After false discovery rate correction for multiple testing, higher infant total and individual NEFA concentrations were associated with a lower weight, length, and head circumference at birth. Higher infant total and individual acyl-lysophosphatidylcholine (lyso.PC.a) and alkyl-lysophosphatidylcholine concentrations were associated with higher weight and head circumference (lyso.PC.a only) at birth, higher odds of LGA and lower odds of SGA. Few individual maternal metabolites were associated with foetal growth measures in third trimester and at birth, but not with the odds of adverse birth outcomes.Conclusions: Our results suggest that infant metabolite profiles, particularly total and individual lyso.PC.a and NEFA concentrations, were strongly related to growth measures at birth and the odds of adverse birth outcomes. Few individual maternal earlypregnancy metabolites, but not total metabolite concentrations, are associated with foetal growth measures in third trimester and at birth.

show abstract

“…A study in Russia has also found a significant association between maternal early pregnancy BMI and risk of preterm birth (Sharashova, Anda, & Grjibovski, 2014). A previous Chilean study has demonstrated that there was a statistically significant association between maternal BMI in early pregnancy and birth weight of the newborn (Caradeux et al, 2016). It is well known that socio-economic factors including income, economy and educational level of mothers are associated with adverse pregnancy outcomes.…”

Section: Factors Affecting Pregnancy Outcomesmentioning

confidence: 97%

Effect of maternal blood heavy metal level on brain-derived neurotrophic factor and pregnancy outcomes among Myanmar migrants in Samut Sakhon province, Thailand

Zaw

View full text Add to dashboard Cite

BACKGROUND: Lead, mercury, cadmium, and arsenic are the priority heavy metals of major public health concern in developing countries. Thailand is a newly industrialized country raising high human workloads of migrant workers form neighbored countries, mostly Myanmar. Exposure to these metals can cause cognitive impairment and depressive disorders through an effect on brain-derived neurotrophic factor (BDNF), which is an important biomarker of pregnancy. Pregnancy outcomes including preeclampsia, preterm birth and low birth weight are major burdens for maternal and child health. Although a number of prior studies have examined the effects of heavy metals on pregnancy, there are few studies focused on migrant population. The aim of this study was to examine the association between maternal blood heavy metals concentrations and BDNF levels and pregnancy outcomes among Myanmar migrants in Thailand. METHODOLOGY: This study was a birth cohort study conducted at the antenatal care clinic of the hospital from July 2018 to April 2019. A total of 119 pregnant Myanmar migrants carrying a single viable fetus of less than 14 weeks of gestation who had stayed within the industrial plant at least 3 months before were recruited in first trimester. The socio-demographic characteristics and health behaviors of the patients were assessed using a self-report questionnaire. Blood samples were collected in first trimester and third trimester. Maternal blood heavy metal (Pb, Hg, Cd, As) concentrations were measured using an inductively coupled plasma mass spectrometer, and plasma BDNF levels were measured using an enzyme-linked immunosorbent assay. Multivariate binary logistic regressions and multiple linear regressions were modeled to evaluate the associations between these factors. RESULTS: A total of 72 pregnant women were completed the study. Median (interquartile rank: IQR) concentrations were as follows: BDNF: (64.60 [15.60]/18.27 [23.40]) ?g/L, Pb: (27.40�[13.80]/19.90�[11.40]) ?g/L, Hg: (6.20 [5.60], 2.60�[2.00]) ?g/L, Cd: (0.91�[0.85]/1.06 [0.46]) ?g/L, and As: (4.00�[1.10]/3.40 [1.40]) ?g/L. We categorized the concentrations into high (? median) and low (<median) groups for binary logistic regressions. After adjusting for potential confounders, patients with a high blood As in first trimester had a 2.6-fold increased risk (aOR = 2.603, 95% CI: 1.178, 5.751) of low plasma BDNF in early pregnancy. Diastolic BP in third trimester was higher in every unit of increased third trimester blood Pb concentrations (? = 2.766, 95% CI: 0.026, 5.506). However, there were no significant associations between heavy metals and preeclampsia, preterm birth or low birth weight. CONCLUSIONS: The present findings demonstrate that pregnant women with higher blood As levels were more likely to have lower BDNF levels in early pregnancy. Pregnant women with high blood Pb have more risk of lower blood pressure in late pregnancy. Public health interventions to address Pb and As exposure should be promoted to improve the health of Myanmar migrants

show abstract

Correlation between Maternal Characteristics during Early Pregnancy, Fetal Growth Rate and Newborn Weight in Healthy Pregnancies

Cited by 4 publications

References 49 publications

Association of Maternal Prepregnancy Body Mass Index With Fetal Growth and Neonatal Thalamic Brain Connectivity Among Adolescent and Young Women

Association of Maternal Prepregnancy Body Mass Index With Fetal Growth and Neonatal Thalamic Brain Connectivity Among Adolescent and Young Women

Associations of maternal and infant metabolite profiles with foetal growth and the odds of adverse birth outcomes

Effect of maternal blood heavy metal level on brain-derived neurotrophic factor and pregnancy outcomes among Myanmar migrants in Samut Sakhon province, Thailand

Contact Info

Product

Resources

About