The association between VDR polymorphisms and renal cell carcinoma susceptibility: a meta-analysis

Abstract

Several studies have reported an association between vascular endothelial growth factor (VEGF) gene polymorphisms rs2010963, rs3025039 and rs699947 and renal cell carcinoma (RCC). However, the results remain inconclusive and controversial. We therefore conducted a meta-analysis to evaluate this association. Electronic databases were searched for relevant case-control studies up to November 2016. RevMan 5.2 software and STATA version 12.0 were used for statistical analysis in our meta-analysis. Heterogeneity was assessed using the I 2 value. Nine eligible studies were retrieved for detailed evaluation. The pooled estimates indicated that the GG genotype of VEGF rs2010963 polymorphism significantly decreased RCC risk [GG vs. GC+CC; GG vs. GC]. There was also a significant association between VEGF rs3025039 polymorphism and RCC susceptibility [CC+CT vs. TT; CC vs. TT]. Furthermore, a significant association between VEGF rs699947 polymorphism and RCC susceptibility was detected [A vs. C; AA+AC vs. CC; AA vs. AC+CC; AA vs. CC; AA vs. AC; AC vs. CC]. Subgroup analysis revealed that these associations held true especially for Asians. Our meta-analysis suggested that there may be a relationship between the VEGF rs2010963, rs3025039 and rs699947 polymorphisms and RCC susceptibility.

Variants ofSCARB1andVDRInvolved in Complex Genetic Interactions May Be Implicated in the Genetic Susceptibility to Clear Cell Renal Cell Carcinoma

“…However, few reports are available on association between VDR polymorphism and renal cell carcinoma and the obtained results are inconsistent [ 48 , 49 ]. Most of the previous studies have been performed on Asian populations [ 50 , 51 ] and recent meta-analyses showed that association of VDR polymorphism with ccRCC may be population specific [ 52 , 53 ]. Polymorphisms included in the haplotype associated with ccRCC in our study are located in the 3′ region of VDR gene and are supposed to influence mRNA level [ 54 ].…”

Vitamin D and urological cancers

“…Several studies have been conducted so far, yet it is not possible to make an authoritative declaration on the role of VDR polymorphisms in renal cancer development and prognosis because of conflicting studies results. However, some polymorphisms have been found to be strongly associated with RCC [ 36 , 37 , 38 ].…”

Association between SNPs in vascular endothelial growth factor polymorphisms and risk of renal cell carcinoma: a case-control study

“…Early diagnosis and medical treatment seems important in decreasing mortality and increasing total quality of life. Several studies have suggested that genetic factors are involved in the development of RCC (Wang et al, 2014;Meng et al, 2014Meng et al, , 2015.…”