Vitamin D and urological cancers

Krajewski, Wojciech; Dzięgała, Mateusz; Kołodziej, Anna; Dembowski, Janusz; Zdrojowy, Romuald

doi:10.5173/ceju.2016.784

Cited by 9 publications

(3 citation statements)

References 99 publications

(112 reference statements)

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“…This can also explain why studies have observed lower concentrations of vitamin D in men with lower urinary tract symptoms (LUTS) ( 71 ). The impact of vitamin D is well described in certain tumors; however, the findings regarding the role of vitamin D in prostate cancer and serum PSA levels are contradictory and lack consistency ( 72 , 73 ). Moreover, there has a possible relationship between vitamin D and urinary tract infection (UTI), erectile dysfunction (ED), and the male reproductive system ( 74 – 78 ).…”

Section: Discussionmentioning

confidence: 99%

Association of serum 25-hydroxyvitamin D concentrations with all-cause mortality among individuals with kidney stone disease: the NHANES database prospective cohort study

Gao,

Liu,

Chen

et al. 2023

Front. Endocrinol.

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BackgroundThe purpose of this study was to investigate the correlation between serum 25(OH)D concentrations and all-cause mortality in patients with kidney stone disease (KSD) as the effects of a deficiency in 25-hydroxyvitamin D on KSD patients are currently unclear.MethodsFor our prospective cohort study, we included 2,916 participants from the National Health and Nutrition Examination Survey (NHANES) 2007-2018. The National Death Index (NDI) was utilized to identify all causes of death and cause-specific mortality until December 31, 2018. We calculated hazard ratios (HR) and 95% confidence intervals (CIs) using multivariate Cox regression models.ResultsDuring the 18,859 person-years of follow-up, a total of 375 fatalities occurred, including 83 deaths from cardiovascular disease (CVD) and 79 deaths from cancer. At baseline, individuals with higher blood 25(OH)D concentrations had lower levels of glucose, glycohemoglobin, CRP, and insulin, as well as higher levels of HDL cholesterol (P < 0.01). In the fully adjusted model (Model 3), compared to the group with the lowest 25(OH)D concentrations, those with serum 25(OH)D concentrations ≥75 nmol/L had hazard ratios (HRs) and 95% confidence intervals (CIs) of 0.48 (0.26, 0.87) for all-cause mortality (P=0.02, P for trend = 0.02). The association between serum 25(OH)D concentrations and all-cause mortality in KSD patients was found to be significantly non-linear. A 7% decrease in the risk of death from all causes was observed for each unit-nmol/L increase in serum 25(OH)D concentrations when the concentrations were below 27.7 nmol/L (P < 0.05).ConclusionBased on the findings, KSD patients with insufficient serum 25(OH)D concentrations were at a higher risk of all-cause mortality. Therefore, it is crucial to maintain sufficient blood 25(OH)D concentrations and prevent 25(OH)D insufficiency in order to extend the lifespan of KSD patients.

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Section: Discussionmentioning

confidence: 99%

Association of serum 25-hydroxyvitamin D concentrations with all-cause mortality among individuals with kidney stone disease: the NHANES database prospective cohort study

Gao,

Liu,

Chen

et al. 2023

Front. Endocrinol.

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“…Vitamin D regulates cellular functions, such as differentiation and proliferation in normal and malignant tissues. It also regulates cell adhesion in tumor cells and modifies tumor angiogenesis, invasion and metastasis along with decreasing oxidative DNA damage (179). Vitamin D deficiency has been associated with various cancer types (180,181).…”

Section: Anabolic Hormonesmentioning

confidence: 99%

Role of anabolic agents in colorectal carcinogenesis: Myths and realities (Review)

et al. 2019

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Colorectal cancer (CRC) is one of the four leading causes of cancer-related mortality worldwide. Even though over the past few decades the global scientific community has made tremendous efforts to understand this entity, many questions remain to be raised on this issue and even more to be answered. Epidemiological findings have unveiled numerous environmental and genetic risk factors, each one contributing to a certain degree to the final account of new CRC cases. Moreover, different trends have been revealed regarding the age of onset of CRC between the two sexes. That, in addition to newly introduced therapeutic approaches for various diseases based on androgens, anti-androgens and anabolic hormones has raised some concerns regarding their possible carcinogenic effects or their synergistic potential with other substances/risk factors, predisposing the individual to CRC. Notably, despite the intense research on experimental settings and population studies, the conclusions regarding the majority of anabolic substances are ambiguous. Some of these indicate the carcinogenic properties of testosterone, dihydrotestosterone (DHT), growth hormone and insulin-like growth factor (IGF) and others, demonstrating their neutral nature or even their protective one, as in the case of vitamin D. Thus, the synergistic nature of anabolic substances with other CRC risk factors (such as type 2 diabetes mellitus, metabolic syndrome and smoking) has emerged, suggesting a more holistic approach.

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“…Vitamin D is the precursor of the steroidal hormone calcitriol ( 9 ), which is currently investigated among various cancers such as gastrointestinal cancers, breast cancers, and urological cancers ( 10 , 11 ). It is generally known that vitamin D plays its key role in the regulation of calcium metabolism ( 12 ); moreover, vitamin D is an inducer of cell differentiation and promotes inhibition of epithelial–mesenchymal transmission ( 13 , 14 ); as well, vitamin D shares antiangiogenic properties ( 15 , 16 ), regulates autophagy ( 17 , 18 ), and induces apoptosis ( 19 , 20 ).…”

Section: Introductionmentioning

confidence: 99%

Prognostic role of plasma vitamin D and its association with disease characteristics in germ cell tumours

et al. 2023

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BackgroundTesticular cancer is the most common malignancy among young men. Vitamin D has pluripotent effects on cancer pathogenesis and plays a role in the metastatic cascade. The aim of this study is to analyze plasma vitamin D in association with clinico-pathological findings and prognosis in patients with germ-cell tumors (GCTs).MethodsThis study included 120 newly diagnosed and/or relapsed GCT patients treated from April 2013 to July 2020, for whom plasma was available in the biobank. Blood samples were drawn the 1st chemotherapy cycle as well as before the 2nd cycle. Plasma vitamin D was measured using ELISA and correlated with disease characteristics and the outcome. For survival analysis, the cohort was dichotomized into “low” and “high” based on median vitamin D.ResultsThere was no significant difference in vitamin D plasma levels between healthy donors and GCT patients (p = 0.71). Vitamin D level was not associated with disease characteristics except for brain metastases, where patients with brain metastases had a vitamin D level that was 32% lower compared to patients without brain metastases, p = 0.03. Vitamin D was also associated with response to chemotherapy, with an approximately 32% lower value in patients with an unfavorable response compared to a favorable response, p = 0.02. Moreover, low plasma levels of vitamin D were significantly associated with disease recurrence and inferior progression-free survival (PFS), but not with overall survival (OS) (HR = 3.02, 95% CI 1.36–6.71, p = 0.01 for PFS and HR = 2.06, 95% CI 0.84–5.06, p = 0.14 for OS, respectively).ConclusionOur study suggests the prognostic value of pretreatment vitamin D concentrations in GCT patients. Low plasma vitamin D was associated with an unfavorable response to therapy and disease recurrence. However, it remains to be determined whether the biology of the disease confirms a causative role for low vitamin D and whether its supplementation affects the outcome.

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Vitamin D and urological cancers

Cited by 9 publications

References 99 publications

Association of serum 25-hydroxyvitamin D concentrations with all-cause mortality among individuals with kidney stone disease: the NHANES database prospective cohort study

Association of serum 25-hydroxyvitamin D concentrations with all-cause mortality among individuals with kidney stone disease: the NHANES database prospective cohort study

Role of anabolic agents in colorectal carcinogenesis: Myths and realities (Review)

Prognostic role of plasma vitamin D and its association with disease characteristics in germ cell tumours

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