The association between the Lys751Gln polymorphism in the XPD gene and the risk of bladder cancer

Abstract

The Lys751Gln polymorphism in the XPD gene have been suggested as a risk factor for bladder cancer, however the results were inconclusive. The aim of the current study is to assess the association by meta-analysis. A total of 15 case-control studies concerning the association between the XPD Lys751Gln polymorphism and bladder cancer risk were included in the meta-analysis. The results suggested that the Lys751Gln polymorphism was not associated with an increased risk of bladder cancer in the dominant model (OR = 1.03, 95 % CI 0.95-1.11, P = 0.53 for Lys/Gln+Gln/Gln vs. Lys/Lys) in overall analysis. In the subgroup analysis by ethnicity, no significant association was found in Caucasians or Asians. Other comparatives suggested a slight significant association between the polymorphism with the risk of bladder cancer in the recessive comparative (OR = 1.14, 95 % CI 1.02-1.29, P = 0.03). The current meta-analysis indicated that the Lys751Gln polymorphism in the XPD gene might be a risk factor for bladder cancer. In the future, more large-scale case-control studies are needed to validate our results.

Peyronie’s Disease: A Review of Etiology, Diagnosis, and Management

“…While not related directly to PD, a recent study observed an increased frequency of certain malignancies in DD families when compared with controls, but failed to establish any statistically significant differences in cancer rates between the groups. 56 The same study also reported that of 20 polymorphisms in 12 cancer susceptibility genes studied, one (D312M variant of Xeroderma Pigmentosum complementation group D (XPD) gene, also known as Excision Repair Cross Complementing Rodent Repair Deficiency group 2 (ERCC2)) 57 was significantly associated with DD (OR 1.75, p=0.004). 56 XPD/ERCC2 polymorphisms have also been linked to an increased risk of bladder cancer.…”

A 3′ untranslated region polymorphism rs2304277 in the DNA repair pathway gene OGG1 is a novel risk modulator for urothelial bladder carcinoma

“…() have demonstrated Lys751 (“A” allele), the common isoform to result in a higher number of chromatid aberrations than 751Gln isoform (“C” allele) and its association with suboptimal DNA repair capacity of X‐ray–damaged DNA, thus rendering the common allele to confer a protective effect. Recent meta‐analyses have indicated a borderline association of rs13181 with bladder cancer susceptibility (Xiong et al., ; Li et al., ) and significant association with esophageal cancer risk (Zhu et al., ), so this polymorphism seems to be of little or unknown significance in bladder carcinogenesis.…”

“…It is joined to the basal TFIIH complex and is thought to be involved in separation of the double helix during transcription and NER (Hoeijmakers et al., ; Lunn et al., ). A nonsynonymous polymorphism rs13181 (Lys751Gln) selected in the present investigation has been widely studied in UBC pathology with inconclusive results (Xiong et al., ).…”

Contribution of DNA repair xeroderma pigmentosum group D genotypes to pancreatic cancer risk in the Chinese Han population

“…, 1998 ; Benhamou and Sarasin, 2002 ). Some studies have reported significant associations between codon 751 variants and predisposition to many types of cancer, including melanoma ( Kertat et al , 2008 ), lung ( Wu and Ding, 2014 ), head and neck ( Yuan et al , 2011 ), bladder ( Xiong et al. , 2014 ), and breast ( Yan et al , 2014 ).…”