Effects of zinc oxide nanoparticles and/or zinc chloride on biochemical parameters and mineral levels in rat liver and kidney

Amara, Salem; Slama, Imen Ben; Mrad, Imen; Rihane, Naima; Khemissi, Wahid; Mır, L. El; Rhouma, Khémaïs Ben; Abdelmelek, Hafedh; Sakly, Mohsen

doi:10.1177/0960327113510327

Cited by 41 publications

(28 citation statements)

References 22 publications

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“…The hepato-renal tissues were considered as target organs for ZnO NPs accumulation and toxicity in rats [39]. The observed increase in Zn concentration in the hepato-renal tissue, in the present study, could be attributed to their preferential passage through the lymphatic system, -treated rats group.…”

Section: Data Availability Concerning the Accumulation Of Zno Nps In supporting

confidence: 52%

“…Biochemical analysis of liver and kidney function parameters of AlCl -hepatorenal injured mice treated with ZnO NPs and followed by zinc ions redistribution from the liver to other organs. Another reason for Zn accumulation was the induction of tissues metallothionein (cytosolic cysteine-rich proteins, powerful scavenger of free radicals) [44] for controlling metal homeostasis to maintain cell survival in response to various stimuli [39], and also to the role of Zn in the synthesis, storage, and secretion of insulin [45]. 3 -treated rats indicated their marked elevation, and these results were supported by histopathological examination of the hepato-renal tissue of rats treated with AlCl3, which indicated altered hepatic histo-architecture after 6 w of treatment appearing as vacuolated hepatocytes and leukocytes infiltration.…”

Section: Data Availability Concerning the Accumulation Of Zno Nps In mentioning

confidence: 99%

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Zinc Oxide Nanoparticles Ameliorate Aluminum Chloride-Induced Hepato-Renal Oxidative Stress and Inflammation in Rats

Mahmoud

Kassab

Moneim

2019

Int J Pharm Pharm Sci

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Objective: The present study was designed to evaluate the effect of zinc oxide nanoparticles (ZnO NPs) on Aluminum chloride (AlCl3)-induced hepato-renal injury. Methods: Animals were divided into, I-control group; rats received saline, II-AlCl3 group; animals received 100 mg AlCl3/kg body weight, III-ZnO NPs group; rats received 10 mg ZnO NPs/kg body weight, and IV group ZnO NPs+AlCl3. All rats were administered their respective doses daily for 6 w. Hepatorenal function parameters in sera; aminotransferases, bilirubin, urea, and creatinine were estimated. Lipid peroxide level and nitrite\nitrate ratio, glutathione content, glutathione peroxidase, glutathione reductase, catalase, superoxide dismutase activities and interleukin-1β, tumor necrosis factor-α levels were determined in both tissues. The histopathological and the immunohistochemical investigations of nuclear factor-kB expression were carried out. Results: ZnO NPs treatment to AlCl3-intoxicated rats significantly reduced Al accumulation (at p<0.05) in the hepatorenal tissue and increased zinc accumulation (at p<0.05) in liver and kidney, respectively, with respect to AlCl3-group, thus inhibiting oxidative stress and inflammation parameters represented by lipid peroxidation and nitric oxide levels (at p<0.05) compared to AlCl3 group and elevated antioxidant parameters (at p<0.05), compared to AlCl3 treated group, while suppressed interleukin-1β, tumor necrosis factor-α levels (at p<0.05) and the nuclear factor-kB activation in liver and kidney, especially in the kidney if compared to AlCl3-treated group. Hepatorenal function indices indicated significant decreases compared to AlCl3 group (at p<0.05). Conclusion: Results indicated the ameliorative effect of ZnO NPs on aluminum-induced hepato-renal damage.

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Section: Data Availability Concerning the Accumulation Of Zno Nps In supporting

confidence: 52%

Section: Data Availability Concerning the Accumulation Of Zno Nps In mentioning

confidence: 99%

Zinc Oxide Nanoparticles Ameliorate Aluminum Chloride-Induced Hepato-Renal Oxidative Stress and Inflammation in Rats

Mahmoud

Kassab

Moneim

2019

Int J Pharm Pharm Sci

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“…Compared with micron-sized particles, nanoparticles (NPs) due to its diverse physicochemical properties (size and surface modifications) are absorbed by the respiratory system, skin, and gastrointestinal tract (1). It has been accounted for that NPs accumulate in liver, kidneys, brain and spleen of rodents (2)(3)(4)(5). Metal NPs are broadly utilized as a part of different businesses.…”

Section: Introductionmentioning

confidence: 99%

Nephrotoxic effects of low-dose zinc oxide nanoparticles in rats

Khorsandi¹,

Moghadam²,

Jozi³

2018

J Nephropathol

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Background: The use of zinc oxide nanoparticles (ZNPs) in various products such as biosensors, sunscreens and nourishment added substances is increasing. Objectives: In the present work the impacts of ZNP on kidney of rats was explored. Materials and Methods: In this experimental study male Wistar rats were used. Trial groups received 5, 50 and 300 mg/kg ZNP (ZNP-1 to ZNP-3) for 2 weeks. Control group received only normal saline. blood urea nitrogen (BUN), creatinine (Cr) and uric acid were considered as biomarkers to indicate nephrotoxicity. To evaluate the oxidative stress in the kidney, malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GPx) enzymes activity were measured. Histopathological and apoptotic cell death was also evaluated in renal tissues.Results: Blood density of zinc (Zn) was significantly increased in the low dose-treated rats. Concentration of Zn in the renal tissue was significantly increased in the high dose treated rats. Weight of kidney was significantly elevated in both ZNP-1 and ZNP-2 groups. ZNP resulted in a significant increment in MDA content in the low measurements and a critical reduction in the activity of the SOD and GPx enzymes. Exposure of ZNP at low dose induced a significant elevation in blood concentration of BUN, Cr and uric acid. Treatment with low dose of ZNP caused a significant increase in histological changes and apoptotic index. ZNP at the high dose induced poor nephrotoxicity. Conclusion: In conclusion, ZNP has dose-dependent nephrotoxic effects on rats and lower doses have more toxic action. ABSTRACT Implication for health policy/practice/research/medical education:In this study we demonstrated that zinc oxide nanoparticles (ZNPs) dose-dependently induced nephrotoxicity by elevation blood biochemical markers and generation of stress oxidative. ZNPs dose-dependently induced structural changes and increased apoptosis in renal tissue. Lower doses of this nanoparticle have more nephrotoxicity effects. The results of this study highlighted the requirement for alert during the utilization of ZNPs to prevent health impacts. Please cite this paper as: Khorsandi L, Heidari-Moghadam A, Jozi Z. Nephrotoxic effects of low-dose zinc oxide nanoparticles in rats. J Nephropathol. 2018;7(3):158-165.

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“…ZnO nanoparticles were also found to induce oxidative stress in cells indicated by depletion of glutathione (59% and 51%); catalase (64% and 55%) and superoxide dismutase (72% and 75%) at 0.8 and 0.08 μg/ml respectively [15]. It is expected that ZnO might also contribute to the histological changes appearing after intraperitoneal injection [16,17]. Zinc oxide or Titanium oxide nanoparticles do not penetrate the stratum corneum so the chance of dermal toxicity by formulation is very rare [18].…”

Section: Discussionmentioning

confidence: 99%

Acute Toxicity and Efficacy of Nanomaterial based Decontamination Formulation Developed for Personal Decontamination against Chemical Warfare Agents

Gautam¹,

Prasad²,

Singh³

et al. 2019

TOBIOMJ

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Background: This study addresses the efficacy of nanomaterials based formulation developed for personal decontamination application against chemical warfare agents and used in Personal Decontamination Kit (PDK). It has the potential to decontaminate the skin of an individual, protective equipment, and small arms contaminated with chemical warfare agents. As this formulation has been developed for personal decontamination, risk of nanomaterial toxicity would always be there while sprinkling or applying to the affected area. It may get into the body through various routes specifically through the inhalation route. Aim: The aim of this study was to evaluate in vivo decontamination efficiency of the formulation and acute inhalation, intratracheal, intranasal, oral, dermal, and intraperitoneal toxicity of the formulation. Materials and Methods: 14 days survival was recorded for the evaluation of decontamination efficiency of this formulation. Various endpoints were considered while assessing the toxicity of Nanomaterial Decontamination Formulation which include Organ Body Weight Index (OBWI), serum biochemical parameters, and respiratory variables like tidal volume, respiratory rate, time of inspiration, time of expiration, etc. LD50 of the formulation were also determined for various routes. As skin is the primary organ to come in contact with the decontaminant, its primary skin irritation response has also been determined in this study. Results and Conclusion: It was found that there is no gross acute toxicity observed at different doses. Though there were some changes in the initial respiratory pattern, they were all later recovered. The preliminary histological evaluation did not show any adverse effect on various organs after exposure with NDF.

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Effects of zinc oxide nanoparticles and/or zinc chloride on biochemical parameters and mineral levels in rat liver and kidney

Cited by 41 publications

References 22 publications

Zinc Oxide Nanoparticles Ameliorate Aluminum Chloride-Induced Hepato-Renal Oxidative Stress and Inflammation in Rats

Zinc Oxide Nanoparticles Ameliorate Aluminum Chloride-Induced Hepato-Renal Oxidative Stress and Inflammation in Rats

Nephrotoxic effects of low-dose zinc oxide nanoparticles in rats

Acute Toxicity and Efficacy of Nanomaterial based Decontamination Formulation Developed for Personal Decontamination against Chemical Warfare Agents

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