Pyrolysis characteristics of Radix Rhizoma Rhei, Cortex Moudan Radicis, and Radix Sanguisorbae and correlations with the carbonizing process of Chinese herbs

Meng, Xianghe; Guo, Xiaojie; Cui, Nannan; Ma, Jie; Zhang, Shuosheng; Fan, Zhongwei

doi:10.1016/s1875-5364(14)60010-8

Cited by 5 publications

(4 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We have applied these techniques to streamline the processing of traditional Chinese medicines. Previously, we used TG/DTG methods to simulate the processing procedure of Zushima, in order to qualitatively demonstrate the overall compositional changes [10,11], and also analyzed the effects of pyrolysis in an inert Ar atmosphere on the preparation of gallic acid, rhubarb, mudan and burnet [12]. We also calculated the energy dynamics during the stir-frying process based on the data obtained from thermal analysis techniques [13].…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Effect of the Degree of Processing of Radix Rehmanniae Preparata (Shu Dihuang) on Shu Dihuangtan Carbonization Preparation Technology

Meng

Guo

et al. 2017

Molecules

View full text Add to dashboard Cite

Carbonization of Radix Rehmanniae Preparata (Shu Dihuangtan) via stir-frying could increase its homeostasis maintaining and antidiarrheal effects. To ensure these pharmacological functions, the quality of the raw material (processed Rehmanniae Radix) must be well controlled. Therefore, we analyzed the effects of different degrees of processing and adjuvants on processed Rehmanniae Radix (Shu Dihuang) by High Performance Liquid Chromatography (HPLC) chromatographic fingerprints, thermal gravimetric analysis and Fourier transform infrared spectroscopy (FTIR). Based on the results from HPLC fingerprints combined with similarity analysis (SA) and hierarchical cluster analysis (HCA) the optimum processing method for Shu Dihuang was five cycles of steaming and polishing, which follows the ancient processing theory. The intensity of thermal weight loss rate peaked near 210.33 ± 4.32 °C or 211.33 ± 2.62 °C, which was an important indicator for the degree of processing of Shu Dihuang. A temperature near 290.89 ± 2.51 °C was the upper limit for carbonizing Shu Dihuangtan. FTIR spectroscopy analysis showed that the overall chemical composition of Shu Dihuangtan was affected by both the degree of processing and adjuvant, which are very important for its quality.

show abstract

Section: Introductionmentioning

confidence: 99%

Investigation of the Effect of the Degree of Processing of Radix Rehmanniae Preparata (Shu Dihuang) on Shu Dihuangtan Carbonization Preparation Technology

Meng

Guo

et al. 2017

Molecules

View full text Add to dashboard Cite

show abstract

“…In early studies, we analyzed the relationship between the pyrolysis characteristics and the partial carbonization in the three medicines under inert gas of Ar [26]. However, under the inert air condition, what observed was the pyrolysis of the herbs themselves, which might be different from what happens in actual carbonization process.…”

Section: Resultsmentioning

confidence: 99%

“…Previously, we used TG/DTG methods to simulate the processing procedure to qualitatively demonstrate the overall compositional changes in the preparation of Zushima [24–25], and analyzed the roles that pyrolysis in inert Ar played in the preparation of gallic acid [21], rhubarb, moutan and burnet [26]. We calculated the energy dynamics during the stir-frying process based on data obtained from the thermal analysis techniques.…”

Section: Introductionmentioning

confidence: 99%

Thermal analysis during partial carbonizing process of rhubarb, moutan and burnet

Meng

Guo

et al. 2017

PLoS ONE

View full text Add to dashboard Cite

Control of temperature and duration of partial carbonization for Chinese medicines have been mainly based on experience of the processors. No quantitative methods and parameters are available that can be used to precisely control the temperature and determine the energy changes during the process. In our research, with a simulated atmosphere air condition, the partial carbonization processes of three Chinese herb medicines rhubarb, moutan and burnet were simulated at different heating rates (5, 10 and 20°C • min-1) and analyzed by thermal gravimetric analysis (TGA) to quantify the upper limits of the temperature. The activation energy was calculated with Friedman, Kissinger-Akahira-Sunose (KAS) method and Ozawa-Flynn-Wall (OFW) methods in iso-conversional models and independent parallel reaction model (IPR). The upper temperatures were calculated to be 280, 184 and 246°C for rhubarb, moutan and burnet, respectively, at corresponding conversion rates of 0.4, 0.2 and 0.1. Calculation of the activation energy has been found impossible with the IPR model. Results obtained from the three iso-conversional methods were different. For rhubarb and burnet, the conversion rates at the upper temperature limits were at the highest or second highest activation energy, while for moutan, it was at the lowest value of activation energy. These results confirmed scientific rationales of traditional Chinese medicine theory that rhubarb and burnet be prepared at high temperature and moutan be prepared at medium temperature. Application of thermal analysis techniques would broaden and deepen traditional Chinese medicine research, and are applicable to the processing of medicinal materials including traditional Chinese medicines. Results obtained from the study could provide new ideas and methods for research to modernize the preparation of traditional Chinese medicines.

show abstract

“…Phellodendri Chinensis Cortex is documented in Chinese Pharmacopoeia ( Chen et al, 2015 ) in three forms, namely, raw (“shengpian” in Chinese, HB), salted products (“yanzhi” in Chinese, YHB), and charring pieces (“tanzhi” in Chinese, THB). As for the clinical application of Phellodendri Chinensis Cortex in China, the raw materials and salted products are mainly applied to diarrhea and jaundice, while the charring pieces are usually utilized for hemostasis ( Meng et al, 2004 ). To date, many studies have been conducted so far on the quality assurance of raw herbs, such as quantitative analysis ( Price et al, 2018 ), chromatographic fingerprinting ( Zhang et al, 2018 ), and extracting techniques ( Wang et al, 2015a ).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of raw and processed Phellodendri Chinensis Cortex using the quality marker analysis strategy by UHPLC-Q-Orbitrap MS and multivariate statistical analysis

Wang,

Shi,

Zhu

2023

Front. Chem.

View full text Add to dashboard Cite

Introduction: Phellodendri Chinensis Cortex is a necessary part of healthcare for its significant clinical efficacy. Raw and processed Phellodendri Chinensis Cortex is both documented in the Chinese Pharmacopoeia (2015). After processing, the therapeutic effects are believed to differ according to traditional Chinese medicine theories. However, the chemical mechanism responsible for this processing, according to traditional Chinese medicine theories, is still not clear.Methods: In this study, the therapeutic effects of various ions were examined based on traditional Chinese medicine theories by ultra-high performance liquid chromatography-hybrid quadrupole-Orbitrap mass spectrometry (UHPLC-Q-Orbitrap MS) coupled with multivariate statistical analysis, such as principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA), to comprehensively compare the differences between raw and processed Phellodendri Chinensis Cortex for the first time.Results: A total of 48 compounds were screened, out and 10 of them simultaneously transformed with significant variation in processed products compared with raw materials. It was illustrated that the contents of berberine, palmatine, jatrorrhizine, magnoflorine, menisperine, phellodendrine, tetrahydrojatrorrhizine, and tetrahydropalmatine decreased, while the compounds of berberrubine and fernloylquinic acid methyl ester newly appeared in processed herbs. This is likely to be related to the conversion of ingredients during processing.Discussion: Altogether, the fact that quality markers have been successfully identified to differentiate processed Phellodendri Chinensis Cortex from raw materials suggests that this approach could be used for the investigation of chemical transformation mechanisms involved in the processing of herbal medicine.

show abstract

Pyrolysis characteristics of Radix Rhizoma Rhei, Cortex Moudan Radicis, and Radix Sanguisorbae and correlations with the carbonizing process of Chinese herbs

Cited by 5 publications

References 5 publications

Investigation of the Effect of the Degree of Processing of Radix Rehmanniae Preparata (Shu Dihuang) on Shu Dihuangtan Carbonization Preparation Technology

Investigation of the Effect of the Degree of Processing of Radix Rehmanniae Preparata (Shu Dihuang) on Shu Dihuangtan Carbonization Preparation Technology

Thermal analysis during partial carbonizing process of rhubarb, moutan and burnet

Evaluation of raw and processed Phellodendri Chinensis Cortex using the quality marker analysis strategy by UHPLC-Q-Orbitrap MS and multivariate statistical analysis

Contact Info

Product

Resources

About