The Usefulness of Ranolazine for the Treatment of Refractory Chronic Stable Angina Pectoris as Determined from a Systematic Review of Randomized Controlled Trials

Banon, D.; Filion, Kristian B.; Budlovsky, Talia; Perrin, Caroline; Eisenberg, Mark J.

doi:10.1016/j.amjcard.2013.11.070

Cited by 30 publications

(23 citation statements)

References 19 publications

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“…Refractory CSAP is defined as the persistence of symptoms resistant to conventional treatments for coronary artery disease (CAD) including revascularization and anti‐anginal medication . CSAP is seen in up to 25% of patients and can result in severely impaired health‐related quality of life . Several randomized controlled trials (RCTs) have examined the role of ranolazine in CSAP .…”

Section: Studied Usesmentioning

confidence: 99%

Ranolazine: A Contemporary Review

Rayner-Hartley

Sedlak

2016

JAHA

251

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Section: Studied Usesmentioning

confidence: 99%

Ranolazine: A Contemporary Review

Rayner-Hartley

Sedlak

2016

JAHA

251

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“…Moreover, taking into account the very low reported mortality rates in SA, in the era of new available pharmacological agents (i.e., ranolazine) [130], a systematic evaluation of s concrete combination of biomarkers and imaging studies in a long-term, large-scale basis is deemed important in order to select patients that would benefit. Future research on microRNAs seems promising in clarifying the vague area of the inflammatory cascade in SA, bridging the pathophysiologic and clinical findings in order to predict outcomes effectively.…”

Section: Discussionmentioning

confidence: 99%

Clinical Usefulness of Novel Serum and Imaging Biomarkers in Risk Stratification of Patients with Stable Angina

et al. 2014

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Inflammatory mediators appear to be the most intriguing yet confusing subject, regarding the management of patients with acute coronary syndromes (ACS). The current inflammatory concept of atherosclerotic coronary artery disease (CAD) led many investigators to concentrate on systemic markers of inflammation, as well as imaging techniques, which may be helpful in risk stratification and prognosis assessment for cardiovascular events. In this review, we try to depict many of the recently studied markers regarding stable angina (SA), their clinical usefulness, and possible future applications in the field.

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“…With respect to the anti-arrhythmic role played by IBD [33], it is generally accepted that IBD inhibits I f currents, a mixed Na + -K + inward current activated by hyperpolarization and modulated by the autonomic nervous system [2]. In addition, I f current is one of the most important ionic currents in regulating pacemaker activity in the sinoatrial (SA) node [34].…”

Section: Discussionmentioning

confidence: 99%

The Effects of Ivabradine on Cardiac Function after Myocardial Infarction are Weaker in Diabetic Rats

Cao¹,

Sun²,

Zhang³

et al. 2016

Cell Physiol Biochem

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Background/Aims: Plasma norepinephrine (NE) and brain natriuretic peptide (BNP, termed BNP-45 in rats) are considered as essential neurohormones indicating heart failure progression. The purposes of this study were to examine the effects of ivabradine (IBD) on cardiac function and plasma NE and BNP-45 after chronic ischemic heart failure (CHF) in non-diabetic rats and diabetic rats. We further determined if sympathetic NE uptake-1 (a major pathway to metabolize NE) mechanism is responsible for the role played by IBD. Methods: We ligated rat's coronary artery to induce CHF; and injected streptozotocin (STZ) to induce diabetic hyperglycemia. Echocardiography was employed to determine cardiac function. We used ELISA to examine plasma NE and BNP-45; and Western Blot analysis to examine the protein levels of NE uptake-1 in sympathetic nerves. Results: CHF increased the levels of NE and BNP-45 in non-STZ rats and STZ rats. Systemic injection of IBD significantly attenuated the augmented NE and BNP-45 and impaired left ventricular function induced by CHF in those rats. This effect appeared to be less in STZ rats. A liner relation was observed between the NE/BNP-45 levels and left ventricular function after administration of IBD. Also, IBD was observed to have a recovery effect on the downregulated NE uptake-1 evoked by CHF, but to a smaller degree in STZ rats. Conclusion: Our data revealed specific signaling mechanisms by which IBD improves the cardiac function as IBD alleviates impaired NE uptake-1and thereby decreases heightened NE and BNP-45 induced by CHF. Our data also demonstrated that the effects of IBD are weakened after diabetic hyperglycemia likely due to worsen NE uptake-1 pathway. Thus, targeting sympathetic NE uptake-1 signaling molecules has clinical implications for treatment and management of CHF in diabetes. Our data were also to shed light on strategies for application of this drug because NE and BNP play an important role in regulation of progression and prognosis of CHF, and in particular, because IBD affects NE uptake-1 pathway in hyperglycemic animals to a less degree.

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The Usefulness of Ranolazine for the Treatment of Refractory Chronic Stable Angina Pectoris as Determined from a Systematic Review of Randomized Controlled Trials

Cited by 30 publications

References 19 publications

Ranolazine: A Contemporary Review

Ranolazine: A Contemporary Review

Clinical Usefulness of Novel Serum and Imaging Biomarkers in Risk Stratification of Patients with Stable Angina

The Effects of Ivabradine on Cardiac Function after Myocardial Infarction are Weaker in Diabetic Rats

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