Increase in Genogroup II.4 Norovirus Host Spectrum by CagA-Positive Helicobacter pylori Infection

Ruvoën-Clouet, Nathalie; Magalhães, Ana; Marcos-Silva, Lara; Breiman, Adrien; Figueiredo, Céu; David, Leonor; Pendu, Jacques Le

doi:10.1093/infdis/jiu054

Cited by 16 publications

(14 citation statements)

References 40 publications

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“…The interaction between rotavirus particles and HBGAs might constitute the first step in the attachment to the cell before internalization of the virus particle, after binding with integrins ( 4 , 5 ). However, other types of ligand, such as non-HBGA ligands and bacteria from intestinal flora, might also play a role during the infection process, as recently shown for noroviruses ( 14 , 15 ).…”

Section: Discussionmentioning

confidence: 91%

Rotavirus P[8] Infections in Persons with Secretor and Nonsecretor Phenotypes, Tunisia

Ayouni¹,

Sdiri-Loulizi²,

Rougemont³

et al. 2015

Emerg. Infect. Dis.

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To determine whether rotavirus infections are linked to secretor status, we studied samples from children in Tunisia with gastroenteritis. We phenotyped saliva for human blood group antigens and tested feces for rotavirus. Rotavirus was detected in 32/114 patients. Secretor genotyping showed that P[8] rotavirus infected secretors and nonsecretors, and infection correlated with presence of Lewis antigen.

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Section: Discussionmentioning

confidence: 91%

Rotavirus P[8] Infections in Persons with Secretor and Nonsecretor Phenotypes, Tunisia

Ayouni¹,

Sdiri-Loulizi²,

Rougemont³

et al. 2015

Emerg. Infect. Dis.

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“…Other types of ligand might play a role during NoV infection. A recent study provided evidence of this, by showing that previous infections with CagA-positive H. pylori might interfere with HBGA expression [18]. Infection with H. pylori is, however, very unlikely in the first years of life.…”

Section: Discussionmentioning

confidence: 98%

“…Nonetheless, susceptibility to NoV infection seems to be much more complex. Recent data have shown that adult non-secretor individuals infected with CagA Helicobacter pylori might become more susceptible because of abnormal expression of fucosylated motifs at the surface of intestinal cells, while it is absent from saliva [18]. Additionally, it has been shown that enteric bacteria from unfiltered stools, such as H antigen-expressing Enterobacter cloacae, promote in vitro infection of B-cells by human NoV [19].…”

Section: Introductionmentioning

confidence: 99%

Relationship between GII.3 norovirus infections and blood group antigens in young children in Tunisia

Ayouni

Estienney

Sdiri-Loulizi

et al. 2015

Clinical Microbiology and Infection

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Noroviruses (NoVs) constitute a major cause of gastroenteritis in Tunisia. One hundred and fourteen matched saliva and stool samples were collected from children (n = 114) suffering from acute gastroenteritis at the hospital of Monastir during the winter season 2011-2012. For 98 of 114 children, blood samples were collected for secretor genotyping. NoVs were associated with 36.8% (n = 42/114) of the gastroenteritis cases. The GII.3 genotype was the most common (69% of all NoVs). For patients who were phenotyped (n = 114) for human blood group antigens (HBGAs), the secretor and non-secretor phenotypes represented 79% and 21%, respectively. Of the NoV infections, 83% were detected in all ABO groups. Five GII.3 isolates, one GII.1 isolate and one GII.7 isolate were detected in Lewis-positive non-secretors, confirmed by genotyping of the FUT2 gene. Even though our data showed that GII.3 NoVs could infect non-secretors, no binding was observed with saliva and GII.3 baculovirus-expressed virus-like particles from the same symptomatic non-secretor individual. This suggests that other factors might also participate in NoV attachment in children and newborns.

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“…These differences could be linked to different genotypes detected in each study or the presence of an HBGA-like substance on the surface of the gut that provides noroviruses with the opportunity to infect intestinal cells [38, 39]. …”

Section: Discussionmentioning

confidence: 99%

Epidemiologic, Virologic, and Host Genetic Factors of Norovirus Outbreaks in Long-term Care Facilities

et al. 2015

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Background In the Unites States, long-term care facilities (LTCFs) are the most common setting for norovirus outbreaks. These outbreaks provide a unique opportunity to better characterize the viral and host characteristics of norovirus disease. Methods We enrolled 43 LTCFs prospectively to study the epidemiology, virology, and genetic host factors of naturally occurring norovirus outbreaks. Acute and convalescent stool, serum, and saliva samples from cases, exposed and nonexposed controls were collected. Norovirus infection was confirmed using quantitative polymerase chain reaction testing of stool samples or 4-fold increase in serum antibody titers. The presence of histo-blood group antigens (secretor, ABO, and Lewis type) was determined in saliva. Results Sixty-two cases, 34 exposed controls, and 18 nonexposed controls from 10 norovirus outbreaks were enrolled. Forty-six percent of acute, 27% of convalescent case, and 11% of control stool samples tested norovirus positive. Outbreak genotypes were GII.4 (Den Haag, n = 3; New Orleans, n = 4; and Sydney, n = 2) and GI.1 (n = 1). Viral load in GII.4 Sydney outbreaks was significantly higher than in outbreaks caused by other genotypes; cases and controls shed similar amounts of virus. Forty-seven percent of cases shed virus for ≥21 days. Symptomatic infections with GII.4 Den Haag and GII.4 New Orleans were detected among nonsecretor individuals. Conclusions Almost half of all symptomatic individuals shed virus for at least 21 days. Viral load was highest in GII.4 viruses that most recently emerged; these viruses also infect the nonsecretor population. These findings will help to guide development of targeted prevention and control measures in the elderly.

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Increase in Genogroup II.4 Norovirus Host Spectrum by CagA-Positive Helicobacter pylori Infection

Abstract: Infection by CagA-positive H. pylori induces expression of GII.4 attachment factors in nonsecretors' mucosa, expanding the host range of these strains and thereby possibly contributing to their epidemiological dominance.

Cited by 16 publications

References 40 publications

Rotavirus P[8] Infections in Persons with Secretor and Nonsecretor Phenotypes, Tunisia

Rotavirus P[8] Infections in Persons with Secretor and Nonsecretor Phenotypes, Tunisia

Relationship between GII.3 norovirus infections and blood group antigens in young children in Tunisia

Epidemiologic, Virologic, and Host Genetic Factors of Norovirus Outbreaks in Long-term Care Facilities

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