SOLUBILITY OF AMMONIUM ACID URATE NEPHROLITHS FROM BOTTLENOSE DOLPHINS (<i>TURSIOPS TRUNCATUS</i>)

Argade, Sulabha; Smith, Cynthia R.; Shaw, Timothy I.; Zupkas, Paul; Schmitt, Todd L.; Venn‐Watson, Stephanie; Sur, Roger L.

doi:10.1638/2012-0148r.1

Cited by 6 publications

(5 citation statements)

References 14 publications

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“…Urate solubility increases with increasing urine pH. Although the solubility of ammonium urate is thought to plateau at pH ≥ 7.2, in vitro dissolution occurred a high rate at pH ≥ 8.0 …”

Section: Partmentioning

confidence: 99%

“…Although the solubility of ammonium urate is thought to plateau at pH ≥ 7.2, in vitro dissolution occurred a high rate at pH ≥ 8.0. 73 Dietary purines are precursors of urate and found in virtually all foods. High-purine foods often are synonymous with high-protein foods, especially those containing organ meats and fish.…”

Section: Recommendation 31: Prevent Sterile Struvite Uroliths By Feementioning

confidence: 99%

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ACVIMSmall Animal Consensus Recommendations on the Treatment and Prevention of Uroliths in Dogs and Cats

Lulich

Berent

Adams

et al. 2016

Veterinary Internal Medicne

145

155

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In an age of advancing endoscopic and lithotripsy technologies, the management of urolithiasis poses a unique opportunity to advance compassionate veterinary care, not only for patients with urolithiasis but for those with other urinary diseases as well. The following are consensus‐derived, research and experience‐supported, patient‐centered recommendations for the treatment and prevention of uroliths in dogs and cats utilizing contemporary strategies. Ultimately, we hope that these recommendations will serve as a foundation for ongoing and future clinical research and inspiration for innovative problem solving.

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Section: Partmentioning

confidence: 99%

Section: Recommendation 31: Prevent Sterile Struvite Uroliths By Feementioning

confidence: 99%

ACVIMSmall Animal Consensus Recommendations on the Treatment and Prevention of Uroliths in Dogs and Cats

Lulich

Berent

Adams

et al. 2016

Veterinary Internal Medicne

145

155

View full text Add to dashboard Cite

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“…All kidney stones previously reported from this managed collection have been pure AU (3). Previous studies in managed collections have shown that urinary citrate was significantly lower than free-ranging dolphins (1–3). Here we considered whether age, feeding, and dietary differences between these two populations may lead to lower risk of AU stone formation.…”

Section: Discussionmentioning

confidence: 98%

“…Kidney stones reported in dolphins have been exclusively composed of AU (3), which is a stone type rarely found in humans in developed countries (4). While it has been hypothesized that some dolphin populations are at higher risk of nephrolithiasis than others, including managed collection vs. free-ranging dolphins, there have been no formal comparisons of stone prevalence between populations (1).…”

Section: Introductionmentioning

confidence: 99%

Comparison of Nephrolithiasis Prevalence in Two Bottlenose Dolphin (Tursiops truncatus) Populations

Smith¹,

Venn‐Watson²,

Wells³

et al. 2013

Front. Endocrinol.

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In humans, ammonium urate (AU) nephrolithiasis is rare in the Western hemisphere and more common in Japan and developing countries. Among a variety of risk factors, insulin resistance has been associated with urate nephrolithiasis in people. Bottlenose dolphins (Tursiops truncatus) are susceptible to AU nephrolithiasis, and it is believed that some populations are more likely to develop nephrolithiasis compared to others. In an effort to better understand population-based risk factors for AU nephrolithiasis in dolphins and their comparative value to humans, sonographic evaluation was performed on dolphins from a managed collection in San Diego Bay, CA (n = 40) and dolphins from a free-ranging, nearshore population in Sarasota Bay, FL (n = 39) to look for evidence of nephrolithiasis. While 14 (35%) of San Diego Bay dolphins evaluated for the study had sonographic evidence of nephrolithiasis, none of the Sarasota Bay dolphins had evidence of disease. Presence or absence of stones was confirmed by computed tomography in a subset of the San Diego collection (n = 10; four dolphins with stones, six without stones). Age was identified as a risk factor, as dolphins with stones in the San Diego collection were significantly older than dolphins without stones (25.4 vs. 19.1 years, respectively; P = 0.04). Additionally, San Diego dolphins included in the study were significantly older than Sarasota Bay dolphins (21.3 vs. 13.8 years, respectively; P = 0.008). In addition to the previously reported risk factors of hypocitraturia and hyperinsulinemia in bottlenose dolphins, other potential factors include geographic location, managed vs. free-ranging status, prey species, and feeding schedules.

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“…Urinary system affections: Argade et al (2013) have identified several cases of nephrolithiasis in managed populations of bottlenose dolphins (Tursiops truncatus); most of these nephroliths are composed of 100% Ammonium Acid Urate (AAU). Several therapies are being investigated to treat and prevent nephrolithiasis in dolphins.…”

Section: Respiratory System Affectionsmentioning

confidence: 99%

Synopsis on the Most Common Pathologies of Dolphins

Eissa¹,

Abu‐Seida²

2015

J. of Fisheries and Aquatic Science

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Dolphins are one of the most iconic species of the marine world. With their playful nature and high intelligence, dolphins have enthralled the hearts of people of all ages from all over the world. The worldwide distribution of dolphins through the diverse global aquatic environments has gifted them with global popularity compared to other aquatic animals in direct contact with the human communities. In the past few decades, deaths, injuries, toxicities, genetic disorders and overfishing were continuously increasing due to faulty anthropogenic activities in th marine environment. The increasing global threats to dolphins' populations have remarkably enhanced the public awareness about these threats and triggered scientific communities to configure reliable/effective solutions. Combating trans-species infectious diseases and development of reliable, safe and cheaper diagnostic as well as therapeutic tools for tissue alterations were the infrastructure of dolphins' veterinary research through the past few decades. However, the veterinary library is suffering from remarkable scarcity of comprehensive literatures about diseases/disorders affecting different body systems of marine mammals. Thus, we present the current review in trial to shed the light on the most common affections of dolphins as a model of the most critically impacted marine mammals.

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SOLUBILITY OF AMMONIUM ACID URATE NEPHROLITHS FROM BOTTLENOSE DOLPHINS (TURSIOPS TRUNCATUS)

Cited by 6 publications

References 14 publications

ACVIMSmall Animal Consensus Recommendations on the Treatment and Prevention of Uroliths in Dogs and Cats

ACVIMSmall Animal Consensus Recommendations on the Treatment and Prevention of Uroliths in Dogs and Cats

Comparison of Nephrolithiasis Prevalence in Two Bottlenose Dolphin (Tursiops truncatus) Populations

Synopsis on the Most Common Pathologies of Dolphins

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