Short-term exercise-induced improvements in bone properties are for the most part not maintained during aging in hamsters

Koistinen, Arto; Halmesmäki, Esa P.; Iivarinen, Jarkko; Arokoski, Jari; Brama, P. A. J.; Jurvelin, Jukka S.; Helminen, Heikki J.; Isaksson, Hanna

doi:10.1016/j.exger.2013.12.017

Cited by 4 publications

(3 citation statements)

References 51 publications

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“…Enriched or furnished cages (FUR) in comparison to conventional cages (CON) provide more space for movement, more opportunity for load bearing exercise such as perching, jumping etc., and support for expression of normal behavior such as scratching, perching, preening etc. Rearing pullets in FUR could be one way of enhancing bone mineralization and strength in pullets ( Campbell et al., 2019 ) because exercise positively enhances bone development ( Greene et al., 2006 ; Koistinen et al., 2014 ; Yuan et al., 2016 ; Patel et al., 2020 ). Mineral nutrition especially Ca and P plays a pivotal role in establishing and sustaining bone quality ( Lukić et al., 2009 ; Korver, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Cage type and mineral nutrition had independent impact on skeletal development in Lohmann LSL-Lite pullets from hatch to 16 weeks of age

2021

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The effects of rearing cage type and dietary Ca, available P and vitamin D 3 (VitD 3 ) on body and skeletal development were studied. A total of 3,420 Lohmann LSL-Lite day-old chicks were reared in conventional (CON) or furnished cages (FUR) to 16 wk of age. Initially, 40 and 150 chicks/cage were placed in CON and FUR and transitioned to 20 and 75 chicks/cage at 8 wk of age, respectively. Three diets: Diet 1, Diet 1.5 and Diet 2 were formulated to meet nutrient specifications with Diet 1.5 and Diet 2 containing 1.5 and 2 times more Ca, P and VitD 3 than Diet 1, respectively. Diets were allocated within cage type to give 6 replicates and fed in 3 feeding programs: starter, grower and developer. At 4, 12 and 16 wk of age, BW was recorded, and femur, tibia and blood samples for bone quality and related parameters. There were no interactions ( P > 0.05) of cage type, diet and pullet age on BW, plasma Ca and inorganic P, femur and tibia morphometry, mineral density (MD), breaking strength (BS) and ash concentration (AC). Concentration of Ca, P and VitD 3 linearly decreased BW ( P < 0.001), relative femur ( P = 0.010) and tibia weight ( P = 0.013). A quadratic increase on femur MD ( P = 0.03) and BS ( P = 0.026) was observed with dietary concentration of Ca, P and VitD 3 . Femur ( P = 0.031) was longer for CON than FUR pullets, however, femur for FUR pullets had higher ( P = 0.003) AC. Cage had no effect ( P ≥ 0.415) femoral MD and BS. Pullets reared in FUR cages exhibited higher tibial MD ( P = 0.015), BS ( P = 0.071), AC ( P < 0.01) and whole-body mineral content ( P < 0.01). In conclusion, cage type and diets showed independent effect on femur and tibia quality with FUR pullets exhibiting enhanced indices of mineralization. Feeding pullets twice the recommended Ca, P and VitD 3 decreased BW, relative weight of leg bone but enhanced femoral strength with no effects on tibia attributes.

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Section: Introductionmentioning

confidence: 99%

Cage type and mineral nutrition had independent impact on skeletal development in Lohmann LSL-Lite pullets from hatch to 16 weeks of age

2021

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“…It has been reported that exercise-induced changes in bone composition are inbred mouse strain [ 28 ] and gender [ 29 ] specific; aging may also influence the adaption of bone composition to mechanical loading. Most studies examining if bone composition is influenced by loading have focused on young animals or examined how exercise early in life may have long-lasting effects later in life [ 19 , 30 ]. Unfortunately, few studies have examined the effect of loading on bone composition in older animals.…”

Section: Introductionmentioning

confidence: 99%

Effect of in vivo loading on bone composition varies with animal age

Aido

Kerschnitzki

Hoerth

et al. 2015

Experimental Gerontology

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Loading can increase bone mass and size and this response is reduced with aging. It is unclear, however how loading affects bone mineral and matrix properties. Fourier Transform Infrared Imaging and high resolution synchrotron scanning small angle X-ray scattering were used to study how bone’s microscale and nanoscale compositional properties were altered in the tibial midshaft of young, adult, and elderly female C57Bl/6J mice after two weeks of controlled in vivo compressive loading in comparison to physiological loading. The effect of controlled loading on bone composition varied with animal age, since it predominantly influenced the bone composition of elderly mice. Interestingly, controlled loading led to enhanced collagen maturity in elderly mice. In addition, although the rate of bone formation was increased by controlled loading based on histomorphometry, the newly formed tissue had similar material quality to new bone tissue formed during physiological loading. Similar to previous studies, our data showed that bone composition was animal and tissue age dependent during physiological loading. The findings that the new tissue formed in response to controlled loading and physiological loading had similar bone composition and that controlled loading enhanced bone composition in elderly mice further supports the use of physical activity as a noninvasive treatment to enhance bone quality as well as maintain bone mass in individuals suffering from age-related bone loss.

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“…Exercise studies led to alterations in the organic matrix by increased bone collagen synthesis [29] and/or altered tensional properties of the collagen network [30,31]. Unfortunately, most previous studies on the topic have focused on young animals or how exercise early in life affects bone quality later in life [32,33]. Isaksson et al [30] showed that voluntary exercise (continuous access to a running wheel beginning at the age of 1 month in C57Bl6 male mice) led to improved tensional properties of the collagen network when the mice were still young and growing (2 and 4 month old), but not when the mice were adults (6 month old).…”

Section: Introductionmentioning

confidence: 99%

Skeletal maturation substantially affects elastic tissue properties in the endosteal and periosteal regions of loaded mice tibiae

et al. 2015

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Short-term exercise-induced improvements in bone properties are for the most part not maintained during aging in hamsters

Cited by 4 publications

References 51 publications

Cage type and mineral nutrition had independent impact on skeletal development in Lohmann LSL-Lite pullets from hatch to 16 weeks of age

Cage type and mineral nutrition had independent impact on skeletal development in Lohmann LSL-Lite pullets from hatch to 16 weeks of age

Effect of in vivo loading on bone composition varies with animal age

Skeletal maturation substantially affects elastic tissue properties in the endosteal and periosteal regions of loaded mice tibiae

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