Detailed in vivo visualization of stent fracture causing focal restenosis using 3D reconstruction software for high-resolution optical coherence tomography images

Hiltrop, Nick; Cock, Dries De; Ferdinande, Bert; Adriaenssens, Tom

doi:10.1093/ehjci/jet273

Cited by 6 publications

(4 citation statements)

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“…Despite various stent enhancement modalities, angiography has limited capacity for showing vessel wall features, luminal masses, stent struts and wire positions. OCT provides this information in high-resolution crosssectional images 8 and three-dimensional (3D) reconstructions [9][10][11] .…”

Section: Introductionmentioning

confidence: 99%

OCT for bifurcation stenting: what have we learned?

Holm¹,

Adriaenssens²,

Motreff³

et al. 2015

EuroIntervention

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Treatment of bifurcation lesions by percutaneous coronary intervention (PCI) shows major variation in complexity. Intravascular optical coherence tomography (OCT) provides high-resolution images of the pathoanatomy, thrombus, wires and stent positions during the procedure. This information may prove crucial in optimising PCI results and clinical outcomes after complex bifurcation treatment. Mounting evidence confirms the feasibility of OCT in bifurcations, and specific steps where OCT may be advantageous in guiding bifurcation PCI have been identified. Awaiting major clinical outcome trials, OCT has already entered the European guidelines for myocardial revascularisation. This paper aims to provide an overview of the potential clinical use of OCT in bifurcations.

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Section: Introductionmentioning

confidence: 99%

OCT for bifurcation stenting: what have we learned?

Holm¹,

Adriaenssens²,

Motreff³

et al. 2015

EuroIntervention

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“…Sometimes, stent fracture is followed by longitudinal overlapping that shows up as a single arc of double layers of stent struts in the same circumference on consecutive frames in the middle of a single stent ( 99 ). Three-dimensional OCT provides further help in challenging cases such as single strut fractures ( 105 , 106 ). Nevertheless, stent-boost technology and multidetector computed tomography can frequently make the diagnosis obviating the need for dedicated intracoronary imaging ( 107 , 108 ).…”

Section: Prevention Of Restenosismentioning

confidence: 99%

Intravascular imaging in coronary stent restenosis: Prevention, characterization, and management

Abouelnour

Gori²

2022

Front. Cardiovasc. Med.

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Despite the introduction of drug-eluting stents to combat the neointimal hyperplasia that occurred after BMS implantation, in-stent restenosis is still encountered in a significant number of patients, particularly as increasingly complex lesions are tackled by percutaneous coronary intervention. Many biological and mechanical factors interplay to produce restenosis, some of which are avoidable. Intravascular imaging provided unique insights into various forms of stent-related mechanical issues that contribute to this phenomenon. From a practical perspective, intravascular imaging can therefore help to optimize the stenting procedure to avert these issues. Moreover, once the problem of restenosis eventuates, imaging can guide the management by tackling the underlying identified mechanism. Finally, it can be used to evaluate the re-intervention results. Nevertheless, with the emergence of different treatment options, more evidence is needed to define patient/lesion-specific characteristics that may help to tailor treatment selection in a way that improves clinical outcomes.

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“…Even though stents are routinely used in the majority of cardiovascular catheterization procedures to treat stenotic arteries, their clinical effectiveness is hindered by numerous post deployment complications such as biocorrosion and structural failure [10,11], which may lead to inflammation, thrombosis and ultimately in-stent restenosis [12]. A large number of stents with different geometric and mechanical features are available on the market.…”

Section: Introductionmentioning

confidence: 99%

Mechanical and physio-biological properties of peptide-coated stent for re-endothelialization

et al. 2020

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Background: The aim of this study was to characterize the mechanical and physio-biological properties of peptidecoated stent (PCS) compared to commercialized drug-eluting stents (DESs). Methods: WKYMVm (Trp-Lys-Tyr-Met-Val-D-Met), a stimulating peptide for homing endothelial colony-forming cell was specially synthesized and coated to bare metal stent (BMS) by dopamine-derived coordinated bond. Biological effects of PCS were investigated by endothelial cell proliferation assay and pre-clinical animal study. And mechanical properties were examined by various experiment. Results: The peptide was well-coated to BMS and was maintained and delivered to 21 and 7 days in vitro and in vivo, respectively. Moreover, the proliferation of endothelial cell in PCS group was increased (approximately 36.4 ± 5.77%) in PCS group at 7 day of culture compare to BMS. Although, the radial force of PCS was moderated among study group. The flexibility of PCS was (0.49 ± 0.082 N) was greatest among study group. PCS did not show the outstanding performance in recoil and foreshortening test (3.1 ± 0.22% and 2.1 ± 0.06%, respectively), which was the reasonable result under the guide line of FDA (less than 7.0%). The nominal pressure (3.0 mm in a diameter) of PCS established by compliance analysis was 9 atm. The changing of PCS diameter by expansion was similar to other DESs, which is less than 10 atm of pressure for the nominal pressure. Conclusions: These results suggest that the PCS is not inferior to commercialized DES. In addition, since the PCS was fabricated as polymer-free process, secondary coating with polymer-based immunosuppressive drugs such as-limus derivatives may possible.

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Detailed in vivo visualization of stent fracture causing focal restenosis using 3D reconstruction software for high-resolution optical coherence tomography images

Cited by 6 publications

References 0 publications

OCT for bifurcation stenting: what have we learned?

OCT for bifurcation stenting: what have we learned?

Intravascular imaging in coronary stent restenosis: Prevention, characterization, and management

Mechanical and physio-biological properties of peptide-coated stent for re-endothelialization

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