Mannose-binding lectin polymorphisms and the risk of sepsis: evidence from a meta-analysis

Abstract

Several studies have evaluated the association between mannose-binding lectin (MBL) polymorphisms and sepsis. However, the results are inconclusive and conflicting. To better understand the roles of MBL polymorphisms in sepsis, we conducted a comprehensive meta-analysis. All relevant studies were searched from PubMed, EMBASE and Web of Knowledge databases, with the last report up to 7 May 2013. Twenty-nine studies addressing four MBL polymorphisms (-550G/C, -221G/C, structure variant A/O, Gly54Asp) were analysed for susceptibility to sepsis and one study for sepsis-related mortality. Overall, significant associations between structure variant A/O and susceptibility to sepsis were observed for AO + OO vs. AA [odds ratio (OR) 1·27, 95% confidence interval (CI) 1·05-1·52, P = 0·01] and O vs. A (OR 1·19, 95% CI 1·02-1·40, P = 0·03). In subgroup analysis based on age group, increased risk was found in the paediatric group in the dominant model (OR 1·72, 95% CI 1·16-2·56, P = 0·007). Moreover, there was a slight association between the +54A/B polymorphism and susceptibility to sepsis in Caucasians (recessive model: OR 10·64, 95% CI 1·24-91·65, P = 0·03). However, no association was observed for -550G/C and -221G/C polymorphisms both overall and in subgroup analysis. For sepsis-related mortality, only one study suggested AO/OO was associated with in-hospital mortality in pneumococcal sepsis patients after controlling for confounding variables. Our meta-analysis indicated that MBL structure variants might be associated with susceptibility to sepsis but further studies with a large sample size should be conducted to confirm these findings.

Impact of MBL2 gene polymorphisms on the risk of infection in solid organ transplant recipients: A systematic review and meta-analysis

“…Nevertheless, there was no suggestion of an effect on the incidence of posttransplant infection either in the recessive or dominant modeling. This apparent lack of impact for promoter SNPs is concordant with other meta‐analyses focused on the risk of sepsis, tuberculosis, or progression/chronicity of hepatitis B virus infection in nontransplant populations.…”

“…The existence of a network of redundant mechanisms and both soluble and membrane‐bound receptors involved in the recognition of pathogen‐associated molecular patterns may contribute to partially dilute the detrimental effect attributable to impaired MBL production . Interestingly, the absolute values of these RRs were in line with those estimated in the general population for the development of sepsis among carriers of variant alleles of exon 1 SNPs …”

“…Given the relatively low sample sizes (particularly for minor allele populations) and single‐center designs of most existing studies, the meta‐analytic approach offers a valid tool for analyzing the association between MBL2 polymorphisms and posttransplant infection, as previously shown for nonimmunocompromised individuals . Nevertheless, limitations must be acknowledged.…”

“…Over recent years, a number of meta‐analyses have explored the effect of MBL2 gene polymorphisms on the risk of different infectious outcomes in the general population . Nevertheless, such methodology has not been yet applied to the SOT population.…”

Low Serum Mannose Binding Lectin (MBL) Levels and -221 YX Genotype of MBL2 Gene Are Susceptible to Neonatal Sepsis in the Chinese Han Population

“…Studies have found that low serum MBL, usually caused by gene variation, has been related to more frequent and severe infections (6)(7)(8)(9). The associations between MBL2 gene polymorphisms, circulating MBL levels, and susceptibility and out- comes in sepsis have been reported in several studies but have shown conflicting results (10)(11)(12)(13). Moreover, the concentrations of MBL may be diverse in patients with different ethnicities and ages (14).…”