Impact of MBL2 gene polymorphisms on the risk of infection in solid organ transplant recipients: A systematic review and meta-analysis

Abstract

| INTRODUC TI ONLong-term immunosuppression administered to solid organ transplant (SOT) recipients is associated with an increased risk of infectious complications. Current immunosuppressive drugs are mostly aimed at suppressing T cell-mediated adaptive immunity, potentially giving innate immunity a crucial role in protecting against pathogens in the transplant setting. 1,2Mannose-binding lectin (MBL) is a soluble pattern recognition molecule critically involved, along with ficolins, in complement activation through the lectin pathway. 3 This C-type lectin is mainly synthesized in the liver, although extrahepatic sources also exist. By binding to N-acetyl-glucosamine and d-mannose residues on microbial surfaces, MBL activates MBL-associated serine proteases, which cleave complement factors C4 and C2 and induce the formation of

Effects of immunoadsorption combined with membrane filtration on complement markers – results of a randomized, controlled, crossover study

“…Low/null-MBL expression haplotypes (XA/O, O/O) also increased the risk of primary outcome and CMV events. No effect was observed for individual promoter SNPs [27].…”

“…Fernández‐Ruiz et al . performed a meta‐analysis (11 studies comprising 1858 patients, with liver‐transplant recipients accounting for 80.4% of the pooled population) with the aim of investigating the association between post‐transplant bacterial and fungal infections and the variant alleles of the MBL2 gene SNPs in the promoter/5′ untranslated region and exon 1. Cytomegalovirus (CMV) infection and/or disease were considered secondary outcomes.…”

Complement protein levels and MBL2 polymorphisms are associated with dengue and disease severity

“…The association of MBL2 polymorphisms with infectious diseases has previously been documented 13,14 . In particular, the MBL2*OO genotype, the MBL2*O allele and MBL2 haplotypes, which correlate with low MBL levels have been shown to be associated with DHF in a Brazilian study group 18 .…”

“…The MBL2*B , MBL2*C or MBL2*D mutant alleles are referred to as MBL2*O , whereas the wildtype is addressed as MBL2*A . MBL deficiency and MBL2 polymorphisms have been shown to be associated with several infectious and autoimmune diseases 13 , 14 .…”

“…In addition, three promoter polymorphisms (positions, − 550, − 221 and + 4) were shown to regulate plasma MBL levels 12 . The MBL2*B, MBL2*C or MBL2*D mutant alleles are referred to as MBL2*O, whereas the wildtype is addressed as MBL2*A. MBL deficiency and MBL2 polymorphisms have been shown to be associated with several infectious and autoimmune diseases 13,14 .…”