High density lipoproteins improve insulin sensitivity in high-fat diet-fed mice by suppressing hepatic inflammation

McGrath, Kristine; Li, Xiaohong; Whitworth, Phillippa T.; Kasz, Robert; Tan, Joanne; McLennan, Susan V.; Celermajer, David S.; Barter, Philip J.; Rye, Kerry‐Anne; Heather, Alison K.

doi:10.1194/jlr.m043281

Cited by 35 publications

(35 citation statements)

References 35 publications

(49 reference statements)

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“…The infusion of exogenous reconstituted HDL-C potentiated both insulin secretion and skeletal muscle glucose uptake in a small trial with type 2 diabetic patients [32]. ApoA-I treatment was found to increase glucose-stimulated insulin secretion in mice that were fed a high-fat diet [33, 34] and ameliorated β-cell dysfunction by inhibiting β-cell apoptosis [9, 35]. The favourable effects of apoA-I on improving insulin sensitivity have been further investigated in human skeletal muscle cells and adipocytes, in which both HDL-C and apoA-I promoted glucose uptake independently of insulin stimulation [32, 36, 37].…”

Section: Discussionmentioning

confidence: 99%

Low apoA-I is associated with insulin resistance in patients with impaired glucose tolerance: a cross-sectional study

Gao

Yao

et al. 2017

Lipids Health Dis

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BackgroundLow apolipoprotein A-I (apoA-I) is an independent risk factor for atherosclerotic cardiovascular diseases. Insulin resistance predicts the progression of abnormal glucose metabolism, which is the main cause of atherosclerotic cardiovascular disease. In this study, we assessed the potential association between apoA-I levels and insulin resistance in patients with impaired glucose tolerance (IGT) and the possible link between apoA-I and IGT.MethodsThis study evaluated a cross-sectional study of 108 participants with impaired glucose tolerance (IGT group) and 84 controls (control group). ApoA-I and clinical characteristics were measured, and a homeostasis model assessment of insulin resistance (HOMA-IR) was calculated.ResultsThe IGT group exhibited significantly lower apoA-I and higher HOMA-IR levels than the control group (apoA-I: 1.37 ± 0.36 vs 1.57 ± 0.39 g/L; HOMA-IR: 4.21 ± 1.56 vs 2.15 ± 0.99; P < 0.001 for both). ApoA-I was negatively correlated with HOMA-IR in both the IGT and control groups (IGT group: r = −0.269, P = 0.005; control group: r = −0.262, P = 0.016). Multiple stepwise regression analysis showed that low apoA-I levels (β = −1.470, P = 0.002) were independently correlated with high HOMA-IR levels in the IGT group. Moreover, logistic regression analysis identified that low apoA-I was an independent influencing factor for IGT (β = −1.170, OR = 0.310, P = 0.007).ConclusionsApoA-I is inversely associated with insulin resistance in patients with impaired glucose tolerance, and low apoA-I is an independent risk factor for impaired glucose tolerance. These results indicate that apoA-I plays an important role in regulating insulin sensitivity and glucose metabolism in patients with IGT.

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Section: Discussionmentioning

confidence: 99%

Low apoA-I is associated with insulin resistance in patients with impaired glucose tolerance: a cross-sectional study

Gao

Yao

et al. 2017

Lipids Health Dis

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“…Furthermore, treatment with HDL or apoA-I increases insulin secretion and production in isolated pancreatic islets and insulinoma beta cell lines [7,8]. Recent studies have demonstrated that both single and repeated doses of apoA-I can also improve insulin resistance in fat-fed C57Bl6 mice [9,10], as can overexpression of apoA-I [11].…”

Section: Introductionmentioning

confidence: 99%

In vivo PET imaging with [18F]FDG to explain improved glucose uptake in an apolipoprotein A-I treated mouse model of diabetes

et al. 2016

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Aims/hypothesis Type 2 diabetes is characterised by decreased HDL levels, as well as the level of apolipoprotein A-I (apoA-I), the main apolipoprotein of HDLs. Pharmacological elevation of HDL and apoA-I levels is associated with improved glycaemic control in patients with type 2 diabetes. This is partly due to improved glucose uptake in skeletal muscle. Methods This study used kinetic modelling to investigate the impact of increasing plasma apoA-I levels on the metabolism of glucose in the db/db mouse model.

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“…However, this association has not been found to be consistent in previous studies [22][23][24][25] although previous research suggested that ApoA1 affects glucose metabolism via multiple mechanisms, including enhanced insulin secretion [26], increased insulin-independent glucose uptake in muscle and adipose tissues [27,28], improved insulin sensitivity [29], and reversed adipocyte dysfunction [30] and restored adiponectin expression and insulin sensitivity [31] with ApoA1 mimetic peptide. Furthermore, genetic studies suggested that genetic variation in ABCA1 has been associated with the increased risk of T2DM [32], and one study suggested that loss-of-function mutations in ABCA1 were associated with impaired b-cell function, but not with the development of T2DM [33].…”

Section: Discussionmentioning

confidence: 44%

Development of Type-2 Diabetes Mellitus is associated with Low Levels of ApoA1

Wu¹,

Yu²

2016

J Diabetes Metab

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Aims: Type-2 diabetes mellitus (T2DM) has become a major public health crisis in China. We examined the incidence of new T2DM over 4 years for association of clinical factors and lipids with development of T2DM in a community-based population. Methods:We included 923 Chinese subjects who participated in community-organized health checkout in both 2009 and 2013. Health history was collected; physical examination was performed; biochemistry, lipids and glucose were measured. Of 923, 819 were confirmed without T2DM in 2009 and included in the analysis.Results: Sixty-five subjects without T2DM in 2009 were identified as having new T2DM in 2013, 8% (65/819) over 4 years. These 65 subjects, compared to those 754 without new T2DM, were older, more likely to be male and smokers. They had higher BMI, fasting glucose, blood pressure and triglycerides, and lower levels of HDL-C and ApoA1. Multivariate logistic regression identified larger BMI (OR=1.7, 95%CI 1.22-2.39, p=0.002), higher fasting glucose (OR=4.2, 95%CI 2.90-6.19, p<0.001) and low levels of ApoA1 (OR=0.51, 95%CI 0.33-0.76, p=0.002) were independently associated with development of T2DM over 4 years. ROC curves for new T2DM showed that AUC improved from 0.87 to 0.89 when adding ApoA1 to the Framingham Diabetes Risk Model and from 0.85 to 0.89 when adding ApoA1 to a Chinese model. Conclusions:This study showed a high incidence of new T2DM at 8% over 4 years among Chinese and demonstrated a significant and independent association of higher BMI and glucose levels, and lower levels of ApoA1 with development of T2DM.

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High density lipoproteins improve insulin sensitivity in high-fat diet-fed mice by suppressing hepatic inflammation

Cited by 35 publications

References 35 publications

Low apoA-I is associated with insulin resistance in patients with impaired glucose tolerance: a cross-sectional study

Low apoA-I is associated with insulin resistance in patients with impaired glucose tolerance: a cross-sectional study

In vivo PET imaging with [18F]FDG to explain improved glucose uptake in an apolipoprotein A-I treated mouse model of diabetes

Development of Type-2 Diabetes Mellitus is associated with Low Levels of ApoA1

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