Effect of flavonoids on learning, memory and neurocognitive performance: relevance and potential implications for Alzheimer's disease pathophysiology

Vauzour, David

doi:10.1002/jsfa.6473

Cited by 113 publications

(77 citation statements)

References 202 publications

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“…Research has indicated that phytochemicalrich foods, particularly those rich in flavonoids, may exert especially powerful effects on cognitive functions (Vauzour, 2014). Flavonoids have a number of effects on the brain, including a potential of protection of neurons against injuries induced by neurotoxins and promotion of learning and memory (Spencer, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…Over the last decade, growing research has focused on the potential of dietary flavonoids in reducing the risk of AD and other dementing disorders (Vauzour, 2014). Research shows the connection between normal ageing and neurodegenerative diseases such as AD with oxidative stress and inflammatory factors.…”

Section: Introductionmentioning

confidence: 99%

“…Both environmental and genetic factors contribute to the pathogenesis of AD. The formation of extracellular amyloid plaques, and accumulation of intracellular neurofibrillary tangles are the neuropathological symptoms of AD (Vauzour, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Kaempferol promotes memory retention and density of hippocampal CA1 neurons in intra-cerebroventricular STZ-induced experimental AD model in Wistar rats

Darbandi¹,

Ramezani²,

Khodagholi³

et al. 2016

biologija

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Background. Alzheimer's disease (AD) is a progressive degenerative disease which causes memory disorders, decreases cognitive functions and abilities, and results in behavioural changes. Some studies have indicated that the flavonoids are able to cross the blood-brain barrier and have a positive effect on the reduction of neuronal damage disorders in the brain such as Alzheimer's disease.Materials and Methods. ICV administration of streptozotocin (3 mg/kg) was done on the first and the third day of the surgery and the animals' memory was evaluated through passive avoidance tasks. Animals were divided into five groups: Salin-Salin, STZ-Salin, and STZ-different kaempferol doses (5, 7/5, 10 mg/kg). All animals received different doses of kaempferol or saline for 3 weeks starting one day before the surgery. Later, they were put into a learning test. After the memory test, the animals were killed and their brains were fixed with Paraformaldehyde 4%, and tissue processing was done. Finally, density of intact neurons in the CA1 area of the hippocampus in the brains of all groups was investigated.Results. The ICV injections of STZ significantly reduced memory retention and intact pyramidal cells compared to the control group. The kaempferol improved the effects of STZ.Conclusion. Our findings show that kaempferol can optimize cognitive deficits caused by injections of STZ and also has some useful impacts on hippocampal CA1 pyramidal neurons.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Kaempferol promotes memory retention and density of hippocampal CA1 neurons in intra-cerebroventricular STZ-induced experimental AD model in Wistar rats

Darbandi¹,

Ramezani²,

Khodagholi³

et al. 2016

biologija

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“…Over the last years, efforts have been made at investigating the effect polyphenols on neuroinflammation. Although not exhaustive, the main antiinflammatory properties of polyphenols may be summarised by (1) a capacity to downregulate the activity of proinflammatory transcription factors such as NF-kB, Nrf2 or STAT through their influences on a number of glial and neuronal signalling pathways, (2) an inhibitory role on the release of cytokines, such as interleukin IL-1b and TNF-a, from primed microglia, (3) an inhibitory action against the production of NO and PGE2 in response to microglia activation, (4) an ability to inhibit the activation of NADPH oxidase and subsequent ROS generation in activated glia, and (5) an inhibitory action against microglia priming through toll-like receptors (TLR) activation (Gonzalez-Gallego et al, 2010;Vauzour, 2014). For example, fisetin (0.05%, 6 months) reduced the protein expression of inflammatory markers in huAPPswe/PS1DE9 transgenic mice in an ERK-p25-mediated pathway without affecting the mRNA expression of NF-kB1 (Currais et al, 2014).…”

Section: Polyphenols Mitigate Neuroinflammationmentioning

confidence: 99%

Polyphenols and brain health

Vauzour

2017

OCL

Self Cite

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-Accumulating evidence suggests that diet and lifestyle can play an important role in delaying the onset or halting the progression of age-related health disorders and to improve cognitive function. A growing number of dietary intervention studies in humans and animals and in particular those using polyphenol-rich diets have been proposed to exert a multiplicity of neuroprotective actions within the brain, including a potential to protect neurons against injury induced by neurotoxins, an ability to suppress neuroinflammation and a potential to promote memory, learning, and cognitive functions. These effects appear to be underpinned by two common processes. First, they are capable of interactions with critical protein and lipid kinase signalling cascades in the brain, leading to an inhibition of apoptosis triggered by neurotoxic species and to a promotion of neuronal survival and synaptic plasticity. Second, they induce beneficial effects on the vascular system, leading to changes in cerebrovascular blood flow capable of causing enhance vascularisation and neurogenesis, two events important in the maintenance of cognitive performances. Together, these processes act to maintain brain homeostasis and play important roles in neuronal stress adaptation and thus polyphenols might have the potential to prevent the progression of neurodegenerative pathologies.

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“…The use of flavonoids as therapeutic compounds has also been suggested in learning, memory, neurocognitive performances and Alzheimer's disease [147,148] . Recently the beneficial effects of flavanoids have been showed for the alzheimer's pathology in animal and in vitro experimental model [149][150][151][152] .…”

Section: Evidences For the Beneficial Use Of Antioxidants In Neurodegmentioning

confidence: 99%

Antioxidants as a preventive therapeutic option for age related neurodegenerative diseases

Singh

2015

Ther Targets Neurol Dis

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Neurodegenerative diseases: an overview -Neurodegenerative disease term illustrate a range of conditions in which primarily neurons get affected or die. Neurons are the building blocks of the central and peripheral nervous system. Neurons could not reproduce or replace themselves with age therefore, when they get damaged or die they cannot be replaced and lead to specific neurodegenerative disease. Few evidences for the presence of stem cells are reported [1] but still it is not understood whether damaged neuron could regenerate or not. The Parkinson's, Alzheimer's, and Huntington's diseases are the most prevalent age related neurodegenerative diseases of central nervous system involving death of specific neuronal population. The treatment of these neurodegenerative diseases might involve the re-supplementation of specific neuronal population with the help of stem cells but researchers and clinicians did not get noticeable success in this approach yet. Millions of people each year are getting affected by these neurodegenerative diseases and the incidences are increasing further significantly with the extended life expectancy. It has been reported by World Health Organisation (2006) that the number of older people of more than 65 years age are expected to increase to approximately 1 billion in 2030 worldwide. Developing countries like India and China will see the largest increase in numbers of aged persons. Therefore the percentage of aged population in developing countries would increase from 59% to 71% worldwide [2] . Since occurrence of most of the neurodegenerative Advances in our understanding for neurodegenerative mechanisms have increased significantly in last few decades. But still no novel disease modifying therapy has been developed which could prevent the disease progression and drawn our attention towards the development of new alternative therapy. The major obstacle for the development of disease therapy is incomplete knowledge about neurodegenerative mechanisms. Due to the insufficient information about neurodegenerative mechanisms no standard diagnostic tests for the detection of neurodegenerative disease could be develop to date, causes delayed diagnosis and disease worsening. So far the exploratory reports and clinical data have suggested the involvement of oxidative stress, mitochondrial impairment and apoptosis as major neurodegenerative mechanisms. Investigations have elicited that once initiated the degeneration of neurons could not be arrested therefore in the scarcity of curative therapy we should approach for the preventive neurodegenerative therapy. Since oxidative stress has noteworthy involvement in neuronal death solely, and in connection to other death pathways therefore, antioxidants as preventive therapeutics might provide beneficial effects in age related neurodegenerative diseases. With this hypothesis in this review we are discussing about the use of antioxidants as a preventive treatment of neurodegenerative diseases. Such therapies may work in the preventive phase or in curati...

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Effect of flavonoids on learning, memory and neurocognitive performance: relevance and potential implications for Alzheimer's disease pathophysiology

Cited by 113 publications

References 202 publications

Kaempferol promotes memory retention and density of hippocampal CA1 neurons in intra-cerebroventricular STZ-induced experimental AD model in Wistar rats

Kaempferol promotes memory retention and density of hippocampal CA1 neurons in intra-cerebroventricular STZ-induced experimental AD model in Wistar rats

Polyphenols and brain health

Antioxidants as a preventive therapeutic option for age related neurodegenerative diseases

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