Influence of Physical Activity and Nutrition on Obesity-Related Immune Function

Abstract

Research examining immune function during obesity suggests that excessive adiposity is linked to impaired immune responses leading to pathology. The deleterious effects of obesity on immunity have been associated with the systemic proinflammatory profile generated by the secretory molecules derived from adipose cells. These include inflammatory peptides, such as TNF-α, CRP, and IL-6. Consequently, obesity is now characterized as a state of chronic low-grade systemic inflammation, a condition considerably linked to the development of comorbidity. Given the critical role of adipose tissue in the inflammatory process, especially in obese individuals, it becomes an important clinical objective to identify lifestyle factors that may affect the obesity-immune system relationship. For instance, stress, physical activity, and nutrition have each shown to be a significant lifestyle factor influencing the inflammatory profile associated with the state of obesity. Therefore, the purpose of this review is to comprehensively evaluate the impact of lifestyle factors, in particular psychological stress, physical activity, and nutrition, on obesity-related immune function with specific focus on inflammation.

Risk factors for false-negative T-SPOT.TB assay results in patients with pulmonary and extra-pulmonary TB

“…50 In our study, being over-weight (BMI ! 25 kg/m 2 ) was significantly associated with false-negative T-SPOT.TB results in pulmonary TB patients, and IFN-g production (the number of SFCs/million PBMCs) in the T-SPOT.TB test was also depressed in overweight patients.…”

Dietary Inflammatory Index and Risk of Multiple Sclerosis in a Case-Control Study from Iran

“…Moreover, using hospital controls and administering validated FFQs by trained interviewers in a hospital setting might have further reduced recall bias and improved comparability of information across cases and controls. Another limitation is the non-availability of appropriate data on physical activity measure which in present form is fairly poor, and doesn't capture duration, frequency and intensity; and physical activity is known to play a major role in modulating inflammation (38). …”

Obesity-related immune responses and their impact on surgical outcomes

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