Curcumin Treatment Protects Against Renal Ischemia and Reperfusion Injury–Induced Cardiac Dysfunction and Myocardial Injury

Chen, T.-H.; Yang, Y.-C.; Wang, J.-C.; Wang, J.-J.

doi:10.1016/j.transproceed.2013.09.006

Cited by 49 publications

(41 citation statements)

References 8 publications

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“…Moreover, Cur-PMs exhibited stronger cytotoxicity compared with Cur-Sol with the extending of incubation time, indicating that Cur-PMs could improve the cellular uptake of Cur and subsequently enhance the cytotoxicity of Cur. Specially, Cur has no systemic side effects to human organs even at high doses [25,26]. Therefore, it turned out that Cur-PMs could improve the pharmacological activities, but do not have potential side effects to body when taken orally.…”

Section: Cytotoxicity Of Cur-pmsmentioning

confidence: 99%

The mechanism of self-assembled mixed micelles in improving curcumin oral absorption: In vitro and in vivo

Wang

2015

Colloids and Surfaces B: Biointerfaces

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Section: Cytotoxicity Of Cur-pmsmentioning

confidence: 99%

The mechanism of self-assembled mixed micelles in improving curcumin oral absorption: In vitro and in vivo

Wang

2015

Colloids and Surfaces B: Biointerfaces

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“…Based on fundamental research results on the prevention of RIRI, curcumin had a potential effect in scavenging free radicals, inhibiting inflammation and reducing apoptosis to exert a protective effect on the myocardium, liver and kidney of murines, rabbits and canines. Pre-conditioning of curcumin was reported to decrease the RIRI via anti-apoptotic effects [25]; it also reduced renal ischemia reperfusion-induced lung injury and myocardial failure and injury [39, 40]. …”

Section: Discussionmentioning

confidence: 99%

Administration of Curcumin Protects Kidney Tubules Against Renal Ischemia-Reperfusion Injury (RIRI) by Modulating Nitric Oxide (NO) Signaling Pathway

Liu

Zhang

et al. 2017

Cell Physiol Biochem

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Background/Aims: To explore the protective effect of curcumin on renal ischemia-reperfusion injury (RIRI) in rats, and its influence on nephridial tissue’s NO and cGMP levels as well as downstream signaling pathway, to elucidate the possible mechanism of curcumin on RIRI. Methods: 36 Sprague Dawley rats (SD rats) were randomly divided into Sham group, Model group, curcumin (CUR +) Model group, 12 rats per group. They were all given RIRI model preparation by unilateral artery occlusion method. All groups’ β2-MG in urine in 24h, serum Cr and BUN were compared, and UAER were calculated. Nitric oxide synthase (NOS), cGMP-dependent protein kinase (PKG), Caspase-3 expression were all determined by western blot. Nitric oxide (NO), NOS and cGMP levels were also examined by using ELISA. All groups’ nephridial histomorphology and kidney tubules score were evaluated and compared. Results: β2-MG and UAER in urine, serum Cr and BUN, in renal tissue were all elevated in Model of RIRI, indicating the success of animal model of RIRI establishment, and above index in CUR + Model group were all lower than those in Model group. Furthermore, iNOS, NO, cGMP, PKG and Caspase-3 in renal tissue were all increased in Model of RIRI, indicating the NO signaling pathway was activated, which is one of the pathogenesis of RIRI, and above index in CUR + Model group were all lower than those in Model group, suggesting that inactivation of iNOS/NO/cGMP/PKG signaling pathway is one of the reasons that explain the protective effect of curcumin in RIRI. Conclusion: The activation of iNOS/NO/cGMP/PKG signaling pathway and the consequent promoted apoptosis of renal tubules are significantly involved in the pathogenesis of development of RIRI, and curcumin treatment could protect renal tubules against RIRI, at least partially, by suppressing the activated iNOS/NO/cGMP/PKG signaling pathway.

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“…As reported, upon exposure to heat stress, the permeability of the myocardial cell membrane will increase and lead to extracellular release of a series of enzymes, including CK-MB and LDH. These enzymes are generally designated as cardiomyocyte damage-related enzymes and further regarded as important indicators for judging acute myocardial injury (Amani et al 2013;Chen et al 2013;Chon et al 2013;Wu et al 2013), especially CK-MB (Zeren et al 2013). In addition to these enzymes, cytopathological changes like swollen in size, uneven staining in the cytoplasm and vacuolar degeneration were clearly identified in a lot of researches (Chen et al 2015;Tang et al 2013).…”

Section: Discussionmentioning

confidence: 99%

In vitro evaluation of aspirin-induced HspB1 against heat stress damage in chicken myocardial cells

Zhang

et al. 2016

Cell Stress and Chaperones

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To understand the potential association of heat stress resistance with HspB1 induction by aspirin (ASA) in chicken myocardial cells, variations of HspB1 expression and heat stressed-induced damage of myocardial cells after ASA administration were studied in primary cultured myocardial cells. Cytopathological lesions as well as damage-related enzymes, such as creatine kinase-MB (CK-MB) and lactate dehydrogenase (LDH), indicated the considerable protective ability of ASA pre-treatment against acute heat stress. Immunostaining assays showed that heat stress caused HspB1 to relocate into the nucleus, while ASA did not. ELISA analysis, revealed that HspB1 expression induced by ASA averaged 45.62-fold higher than that of the control. These results indicated that the acute heat-stressed injuries were accompanied by comparatively lower HspB1 expression caused by heat stress in vitro. ASA pretreatment induced a level of HspB1 presumed to be sufficient to protect myocardial cells from acute heat stress in the extracorporal model, although more detailed mechanisms will require further investigation.

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Curcumin Treatment Protects Against Renal Ischemia and Reperfusion Injury–Induced Cardiac Dysfunction and Myocardial Injury

Cited by 49 publications

References 8 publications

The mechanism of self-assembled mixed micelles in improving curcumin oral absorption: In vitro and in vivo

The mechanism of self-assembled mixed micelles in improving curcumin oral absorption: In vitro and in vivo

Administration of Curcumin Protects Kidney Tubules Against Renal Ischemia-Reperfusion Injury (RIRI) by Modulating Nitric Oxide (NO) Signaling Pathway

In vitro evaluation of aspirin-induced HspB1 against heat stress damage in chicken myocardial cells

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