Non-traditional adipokines in pediatric HIV-related lipodystrophy: a-FABP as a biomarker of central fat accumulation

Theodoridou, Kalliopi; Margeli, Alexandra; Spoulou, Vana; Bathrellou, Irini; Skevaki, Chrysanthi; Chrousos, George P.; Papassotiriou, Ioannis; Kanaka‐Gantenbein, Christina

doi:10.3109/00365513.2013.859725

Cited by 6 publications

(1 citation statement)

References 23 publications

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“…A close positive association between serum A-FABP levels and the total fat mass has been demonstrated both in lean and overweight/obese individuals 2 18 . Additionally, evidence that serum A-FABP levels are positively correlated with not only total body fat content but also central fat accumulation came from an observational longitudinal study of 17 HIV-infected children 19 . Previously, we performed magnetic resonance imaging to obtain a precise measurement of abdominal fat and discovered that serum A-FABP levels are influenced by the visceral fat content in women after menopause 20 .…”

Section: Discussionmentioning

confidence: 99%

Association of androgen with gender difference in serum adipocyte fatty acid binding protein levels

Pan

Luo

et al. 2016

Sci Rep

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Clinical investigations have indicated women have higher levels of adipocyte fatty acid binding protein (A-FABP) than men. The present study aimed to identify factors related to gender difference in serum A-FABP levels. A total of 507 participants (194 men, 132 premenopausal women, and 181 postmenopausal women) were enrolled in the present study. Serum A-FABP levels increased in the order from men to premenopausal women to postmenopausal women in both body mass index categories (<25.0 and ≥25.0 kg/m2; all P < 0.05). Multiple stepwise regression analyses showed that after adjustment for factors related to serum A-FABP levels, the trunk fat mass was an independent and positive factor of serum A-FABP levels. For men, total testosterone was associated independently and inversely with serum A-FABP levels. For pre- and postmenopausal women, bioavailable testosterone and total testosterone were independent and positive factors associated with serum A-FABP levels, respectively. The present study demonstrated that the androgen was correlated with the serum A-FABP levels negatively in men, but positively in women. With these effects on the fat content, especially trunk fat, androgen might contribute to the gender difference in serum A-FABP levels.

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Section: Discussionmentioning

confidence: 99%

Association of androgen with gender difference in serum adipocyte fatty acid binding protein levels

Pan

Luo

et al. 2016

Sci Rep

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HIV-1 Tat drives the Fabp4/NF-κB feedback loop in microglia to mediate inflammatory response and neuronal apoptosis

Zhou

et al. 2022

J. Neurovirol.

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HIV/antiretroviral therapy–related lipodystrophy syndrome (HALS) is associated with higher RBP4 and lower omentin in plasma

Peraire

López‐Dupla

Alba

et al. 2015

Clinical Microbiology and Infection

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Very little information is available on the involvement of newly characterized adipokines in human immunodeficiency virus (HIV)/antiretroviral therapy (ART)-associated lipodystrophy syndrome (HALS). Our aim was to determine whether apelin, apelin receptor, omentin, RBP4, vaspin and visfatin genetic variants and plasma levels are associated with HALS. We performed a cross-sectional multicentre study that involved 558 HIV type 1-infected patients treated with a stable highly active ART regimen, 240 of which had overt HALS and 318 who did not have HALS. Epidemiologic and clinical variables were determined. Polymorphisms in the apelin, omentin, RBP4, vaspin and visfatin genes were assessed by genotyping. Plasma apelin, apelin receptor, omentin, RBP4, vaspin and visfatin levels were determined by enzyme-linked immunosorbent assay in 163 patients (81 with HALS and 82 without HALS) from whom stored plasma samples were available. Student's t test, one-way ANOVA, chi-square test, Pearson and Spearman correlations and linear regression analysis were used for statistical analyses. There were no associations between the different polymorphisms assessed and the HALS phenotype. Circulating RBP4 was significantly higher (p < 0.001) and plasma omentin was significantly lower (p 0.001) in patients with HALS compared to those without HALS; differences in plasma levels of the remaining adipokines were nonsignificant between groups. Circulating RBP4 concentration was predicted independently by the presence of HALS. Apelin and apelin receptor levels were independently predicted by body mass index. Visfatin concentration was predicted independently by the presence of acquired immunodeficiency syndrome. HALS is associated with higher RBP4 and lower omentin in plasma. These two adipokines, particularly RBP4, may be a link between HIV/ART and fat redistribution syndromes.

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Non-traditional adipokines in pediatric HIV-related lipodystrophy: a-FABP as a biomarker of central fat accumulation

Abstract: This study is the first one to demonstrate that a-FABP could be a useful marker in unraveling central fat accumulation in HIV-infected children on highly-active-antiretroviral-therapy. Large prospective studies are needed to confirm these results.

Cited by 6 publications

References 23 publications

Association of androgen with gender difference in serum adipocyte fatty acid binding protein levels

Association of androgen with gender difference in serum adipocyte fatty acid binding protein levels

HIV-1 Tat drives the Fabp4/NF-κB feedback loop in microglia to mediate inflammatory response and neuronal apoptosis

HIV/antiretroviral therapy–related lipodystrophy syndrome (HALS) is associated with higher RBP4 and lower omentin in plasma

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