Classical NF-κB activation impairs skeletal muscle oxidative phenotype by reducing IKK-α expression

Remels, Alexander; Gosker, Harry R.; Langen, Ramon; Polkey, Michael I.; Sliwiński, P; Gáldiz, Juan B.; Borst, Bram van den; Pansters, N.A.M.; Schols, A.M.W.J.

doi:10.1016/j.bbadis.2013.11.001

Cited by 23 publications

(23 citation statements)

References 40 publications

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“…A recent study has shown that MKP-5 negatively regulates p38 MAPK phosphorylation and reduces the production of inflammatory cytokines in macrophages (28). Canonical NF-κB activation impairs the skeletal muscle oxidative phenotype by reducing the expression of IKKα (29). In the present study, the level of MKP-5 mRNA was supressed by miR-223 overexpression in HGF (Fig.…”

Section: Discussionsupporting

confidence: 64%

Effects of miR-223 on expression of IL-1β and IL-6 in human gingival fibroblasts

Matsui

Ogata

2016

Journal of Oral Science

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Section: Discussionsupporting

confidence: 64%

Effects of miR-223 on expression of IL-1β and IL-6 in human gingival fibroblasts

Matsui

Ogata

2016

Journal of Oral Science

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“…[1] As an inflammatory cytokine, tumor necrosis factor alpha (TNF-α) 36 is known to be one of the key regulators of skeletal muscle. [1] As an inflammatory cytokine, tumor necrosis factor alpha (TNF-α) 36 is known to be one of the key regulators of skeletal muscle.…”

Section: Introduction 32mentioning

confidence: 99%

“…[1] Furthermore, it has been 410 hypothesized that ROS may act as a second message in TNF-α-induced muscle cells. However, 406 chronic inflammation has been implicated in muscle oxidative phenotype deterioration.…”

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confidence: 99%

Low molecular weight guluronate prevents TNF-α-induced oxidative damage and mitochondrial dysfunction in C2C12 skeletal muscle cells

et al. 2015

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Muscle wasting is associated with a variety of chronic or inflammatory disorders. Evidence suggests that inflammatory cytokines play a vital role in muscle inflammatory pathology and this may result in oxidative damage and mitochondrial dysfunction in skeletal muscle. In our study, we used microwave degradation to prepare a water-soluble low molecular weight guluronate (LMG) of 3000 Da from Fucus vesiculosus obtained from Canada, the Atlantic Ocean. We demonstrated the structural characteristics, using HPLC, FTIR and NMR of LMG and investigated its effects on oxidative damage and mitochondrial dysfunction in C2C12 skeletal muscle cells induced by tumor necrosis factor alpha (TNF-α), a cell inflammatory cytokine. The results indicated that LMG could alleviate mitochondrial reactive oxygen species (ROS) production, increase the activities of antioxidant enzymes (GSH and SOD), promote mitochondrial membrane potential (MMP) and upregulate the expression of mitochondrial respiratory chain protein in TNF-α-induced C2C12 cells. LMG supplement also increased the mitochondrial DNA copy number and mitochondrial biogenesis related genes in TNF-α-induced C2C12 cells. LMG may exert these protective effects through the nuclear factor kappa B (NF-κB) signaling pathway. These suggest that LMG is capable of protecting TNF-α-induced C2C12 cells against oxidative damage and mitochondrial dysfunction.

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“…However, patients were characterised by reduced levels of physical activities and evidence of systemic inflammation suggesting that these factors precede the development of overt limb muscle dysfunction in COPD. Translational research by REMELS et al [23], using COPD as a clinical model, showed that inflammation affects skeletal muscle oxidative phenotype through activation of classical nuclear factor-κB and reduction of IκB kinase α expression. In a large cohort of COPD patients, NATANEK et al [24] showed great heterogeneity in muscle morphology and function overlapping those in sedentary healthy subjects.…”

Section: Understanding Copd Complexity From a Metabolic Perspectivementioning

confidence: 99%

Nutritional advances in patients with respiratory diseases

Schols

2015

Eur Respir Rev

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Nutritional issues are increasingly recognised in the course of respiratory diseases, from primary prevention to advanced disease care. During the 2014 ERS International Congress in Munich, Germany, the topic was addressed in a Clinical Year in Review session. This review highlights new insights in generic and disease-specific nutritional issues from recently published peer-reviewed articles. The clinical relevance of obesity was highlighted in primary and secondary prevention across all respiratory diseases. Radiographic imaging was explored for characterisation of metabolic phenotypes as an integrated part of diagnostic work-up. Muscle regenerative defects and the autophagy-lysosome pathway were identified as new leads for combatting muscle wasting. @ERSpublications Nutritional issues need to be considered in respiratory disease, from primary prevention to advanced disease care http://ow.ly/GVI5D

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Classical NF-κB activation impairs skeletal muscle oxidative phenotype by reducing IKK-α expression

Abstract: Classical NF-κB activation impairs skeletal muscle OXPHEN by reducing IKK-α expression. TNF-α-induced reductions in muscle IKK-α may accelerate muscle OXPHEN deterioration in COPD.

Cited by 23 publications

References 40 publications

Effects of miR-223 on expression of IL-1β and IL-6 in human gingival fibroblasts

Effects of miR-223 on expression of IL-1β and IL-6 in human gingival fibroblasts

Low molecular weight guluronate prevents TNF-α-induced oxidative damage and mitochondrial dysfunction in C2C12 skeletal muscle cells

Nutritional advances in patients with respiratory diseases

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