Prevalence, predictors and evolution of echocardiographically defined cardiac abnormalities in adults with type 1 diabetes: an observational cohort study

Wai, Bryan; Patel, Sheila K.; Ord, M.; MacIsaac, Richard J; Jerums, George; Srivastava, Piyush; Burrell, Louise M.

doi:10.1016/j.jdiacomp.2013.09.013

Cited by 23 publications

(19 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Prolonged hyperglycemic exposure leading to alteration in the microvascular circulation and eventually fibrosis is the potential underlying mechanism . Diastolic dysfunction in our study population was more prevalent than systolic dysfunction at 66%, which is comparable with the recently reported 69% in a cohort of 136 T1DM patients …”

Section: Discussionmentioning

confidence: 98%

“…21,22 TA B L E 3 Univariate and multivariate regression analysis for global longitudinal peak systolic strain our study population was more prevalent than systolic dysfunction at 66%, which is comparable with the recently reported 69% in a cohort of 136 T1DM patients. 23 Diastolic dysfunction precedes systolic dysfunction in the T1DM population and is therefore an early marker of cardiac dysfunction and may portend diabetic cardiomyopathy, heart failure, and increased mortality.…”

Section: The Role Of Diastolic Dysfunction In T1dmmentioning

confidence: 99%

See 1 more Smart Citation

Abnormal longitudinal peak systolic strain in asymptomatic patients with type I diabetes mellitus

et al. 2019

View full text Add to dashboard Cite

Aims In addition to increased risk of cardiovascular disease, the prevalence of diabetic cardiomyopathy is increasingly recognized in patients with type 1 diabetes mellitus (T1DM). We aimed to identify the occurrence of subclinical markers of cardiovascular risk and cardiac dysfunction and assess their relation to clinical parameters in asymptomatic patients with T1DM. Methods and results A total of 102 patients (mean age 46 years [20–73], 62% male) with a history of T1DM ranging from 5 to 47 years underwent standard 2D and pulse‐wave tissue Doppler echocardiography (Philips iE33) and computerized tomography for assessment of coronary calcium score (CACS) and visceral fat. Global peak longitudinal strain (GPLSS, speckle tracking) was calculated by offline analysis (Qlab 9.0). Whereas systolic function was preserved in all patients (LVEF > 50%), subclinical dysfunction (defined as global longitudinal peak systolic strain [GLPSS] of >−20%) was present in 39% and 66% had diastolic dysfunction. Fifty patients had a CACS above the 50th percentile according to age and gender. These patients were older, more obese, had higher levels of visceral fat, higher SBP and increased levels of LDL cholesterol. Higher CACS meant increased risk of diastolic and subclinical systolic dysfunction. However, decreased GLPSS was also detected in 30% of patients with CACS of <50th percentile. Stepwise linear regression analysis indicated visceral fat as a strong predictor of abnormal GPLSS and CACS. Conclusion Subclinical left ventricular dysfunction and atherosclerosis were highly prevalent in asymptomatic T1DM. Abnormal GPLSS was noted with or without associated increase in CACS. Visceral fat was a strong predictor of increased CACS as well as abnormal GLPSS.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: The Role Of Diastolic Dysfunction In T1dmmentioning

confidence: 99%

Abnormal longitudinal peak systolic strain in asymptomatic patients with type I diabetes mellitus

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Transthoracic echocardiography was performed as previously described (Wai et al, 2014) according to the recommendations of the American Society of Echocardiography (ASE) (Lang et al, 2015). LV mass was calculated by LV cavity dimensions and wall thickness at end-diastole with the ASE recommended formula as follows (Lang et al, 2015): LV mass (g) = 0.8 × {1.04[(LVEDD + PWTd + SWTd) 3 – (LVEDD) 3 ]} + 0.6 g, where LVEDD is the LV end diastolic dimension, PWTd is the posterior wall thickness diameter and SWT is the septal wall thickness.…”

Section: Methodsmentioning

confidence: 99%

Genetic Variation in Kruppel like Factor 15 Is Associated with Left Ventricular Hypertrophy in Patients with Type 2 Diabetes: Discovery and Replication Cohorts

et al. 2017

Self Cite

View full text Add to dashboard Cite

Left ventricular (LV) hypertrophy (LVH) is a heritable trait that is common in type 2 diabetes and is associated with the development of heart failure. The transcriptional factor Kruppel like factor 15 (KLF15) is expressed in the heart and acts as a repressor of cardiac hypertrophy in experimental models. This study investigated if KLF15 gene variants were associated with LVH in type 2 diabetes. In stage 1 of a 2-stage approach, patients with type 2 diabetes and no known cardiac disease were prospectively recruited for a transthoracic echocardiographic assessment (Melbourne Diabetes Heart Cohort) (n = 318) and genotyping of two KLF15 single nucleotide polymorphisms (SNPs) (rs9838915, rs6796325). In stage 2, the association of KLF15 SNPs with LVH was investigated in the Genetics of Diabetes Audit and Research in Tayside Scotland (Go-DARTS) type 2 diabetes cohort (n = 5631). The KLF15 SNP rs9838915 A allele was associated in a dominant manner with LV mass before (P = 0.003) and after (P = 0.001) adjustment for age, gender, body mass index (BMI) and hypertension, and with adjusted septal (P < 0.0001) and posterior (P = 0.004) wall thickness. LVH was present in 35% of patients. Over a median follow up of 5.6 years, there were 22 (7%) first heart failure hospitalizations. The adjusted risk of heart failure hospitalization was 5.5-fold greater in those with LVH and the rs9838915 A allele compared to those without LVH and the GG genotype (hazard ratio (HR) 5.5 (1.6–18.6), P = 0.006). The association of rs9838915 A allele with LVH was replicated in the Go-DARTS cohort. We have identified the KLF15 SNP rs9838915 A allele as a marker of LVH in patients with type 2 diabetes, and replicated these findings in a large independent cohort. Studies are needed to characterize the functional importance of these results, and to determine if the SNP rs9838915 A allele is associated with LVH in other high risk patient cohorts.

show abstract

“…and median (interquartile range) dialysis duration 13.6 (9.8-19.1) months participated. Galectin-3 was substantially lower following haemodialysis: 55 ng/mL (47-70) versus 23 ng/mL (19)(20)(21)(22)(23)(24)(25)(26)(27), P < 0.001), but other biomarkers changed little. By increasing RRF tertile, post-dialysis galectin-3 was 32.6 ng/mL (23.7-36.6), 21.9 ng/mL (19.0-23.2) and 19.0 ng/mL (16.9-21.0, P = 0.001);…”

mentioning

confidence: 91%

Effect of haemodialysis and residual renal function on serum levels of galectin‐3, B‐type natriuretic peptides and cardiac troponin T

et al. 2018

View full text Add to dashboard Cite

show abstract

Prevalence, predictors and evolution of echocardiographically defined cardiac abnormalities in adults with type 1 diabetes: an observational cohort study

Cited by 23 publications

References 30 publications

Abnormal longitudinal peak systolic strain in asymptomatic patients with type I diabetes mellitus

Abnormal longitudinal peak systolic strain in asymptomatic patients with type I diabetes mellitus

Genetic Variation in Kruppel like Factor 15 Is Associated with Left Ventricular Hypertrophy in Patients with Type 2 Diabetes: Discovery and Replication Cohorts

Effect of haemodialysis and residual renal function on serum levels of galectin‐3, B‐type natriuretic peptides and cardiac troponin T

Contact Info

Product

Resources

About