Construction of nanoparticles based on amphiphilic copolymers of poly(γ-glutamic acid co-l-lactide)-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine as a potential drug delivery carrier

Liu, Xiaoguang; Su, Shishuai; Wei, Fengxiang; Rong, Xianghui; Yang, Zhiwei; Liu, Junxing; Li, Mingjun; Wu, Yan

doi:10.1016/j.jcis.2013.09.022

Cited by 14 publications

(10 citation statements)

References 42 publications

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“…Introduction of hydrophobic spacers to PLGA significantly enhanced its interaction with lectin and its helicity in acidic medium, leading typical coil-to-helix transition [186]. Dox was encapsulated into the NPs fabricated using an amphiphilic copolymer containing PLGA, 1,2-dipalmitoyl- sn -glycero-3-phosphoethanolamine, and polylactide segments by double emulsion and nanoprecipitation methods [187].…”

Section: Types Of Ph-responsive Polypeptidesmentioning

confidence: 99%

pH-Responsive Polypeptide-Based Smart Nano-Carriers for Theranostic Applications

et al. 2019

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Smart nano-carriers have attained great significance in the biomedical field due to their versatile and interesting designs with different functionalities. The initial stages of the development of nanocarriers mainly focused on the guest loading efficiency, biocompatibility of the host and the circulation time. Later the requirements of less side effects with more efficacy arose by attributing targetability and stimuli-responsive characteristics to nano-carriers along with their bio- compatibility. Researchers are utilizing many stimuli-responsive polymers for the better release of the guest molecules at the targeted sites. Among these, pH-triggered release achieves increasing importance because of the pH variation in different organ and cancer cells of acidic pH. This specific feature is utilized to release the guest molecules more precisely in the targeted site by designing polymers having specific functionality with the pH dependent morphology change characteristics. In this review, we mainly concert on the pH-responsive polypeptides and some interesting nano-carrier designs for the effective theranostic applications. Also, emphasis is made on pharmaceutical application of the different nano-carriers with respect to the organ, tissue and cellular level pH environment.

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Section: Types Of Ph-responsive Polypeptidesmentioning

confidence: 99%

pH-Responsive Polypeptide-Based Smart Nano-Carriers for Theranostic Applications

et al. 2019

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“…Интересным является использование γ-ПГК в качестве носителя лекарственных веществ, основы для создания перевязочных материалов и биоклеев [29 -31]. Особенно перспективным считается создание на основе ПГК конъюгатов для лечения онкологических заболеваний, поскольку она является биосовместимой и биодеградабельной [33]. Свободные карбоксильные группы в боковых ответвлениях могут выступать в качестве точек связывания с лекарственными веществами, делая, таким образом, последние более растворимыми и легче транспортируемыми к целевым тканям.…”

Section: таблица 2 сферы применения γ-пгкunclassified

Biological Activity and Biosynthesis of Poly-γ-Glutamic Acid by Bacteria of Bacillus Genus

Хархота¹

2017

Mikrobiol. Z.

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Обзор посвящен исследованиям закономерностей биосинтеза и возможности применения поли-γ-глутаминовой кислоты в различных отраслях промышленности. Показано, что бактерии рода Bacillus наиболее перспективные продуценты полиγ-глутаминовой кислоты в промышленных условиях. Охарактеризовано строение и физиологическая роль поли-γ-глутаминовой кислоты для продуцентов. Обобщены закономерности биосинтеза исследуемого биополимера штаммами бактерий рода Bacillus при их глубинном культивировании. Показано влияние компонентов питательной среды и физико-химических условий выращивания на общий выход и молекулярный вес поли-γ-глутаминовой кислоты. Систематизирована и проанализирована информация о возможности применения поли-γ-глутаминовой кислоты в пищевой и косметической промышленности, для очистки сточных вод, создания нанобиокомпозитных материалов, в том числе медицинского назначения, создания вакцин и конъюгированных химиотерапевтических средств для лечения онкологических заболеваний. Ключевые слова: бактерии рода Bacillus, поли-γ-глутаминовая кислота, разработка лекарственных средств.

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“…␥-PGA-MAL-PLA (Scheme 1b) copolymer was synthesized as previously described with a few modifications [11]. L-Glu-MAL and l-lactide (at a molar ratio of 1:5) were put into a 50 mL flask.…”

Section: Synthesis Of -Pga-mal-plamentioning

confidence: 99%

“…Previously, our group first synthesized ␥-PGA-co-PLA-DPPE copolymer that was used as carrier for hydrophilic drug DOX, which achieved high entrapment efficiency and controlled release in vitro [11]. As one polypeptide contained in copolymer, ␥-polyglutamic acid (␥-PGA) consisting of ␥-carboxy-linked glutamate residues is a excellent biodegradable hydrophilic biomacromolecule.…”

Section: Introductionmentioning

confidence: 99%

Transferrin conjugated poly (γ-glutamic acid-maleimide-co- l -lactide)-1,2-dipalmitoylsn-glycero-3-phosphoethanolamine copolymer nanoparticles for targeting drug delivery

Zhao

Liu

et al. 2014

Colloids and Surfaces B: Biointerfaces

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Construction of nanoparticles based on amphiphilic copolymers of poly(γ-glutamic acid co-l-lactide)-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine as a potential drug delivery carrier

Cited by 14 publications

References 42 publications

pH-Responsive Polypeptide-Based Smart Nano-Carriers for Theranostic Applications

pH-Responsive Polypeptide-Based Smart Nano-Carriers for Theranostic Applications

Biological Activity and Biosynthesis of Poly-γ-Glutamic Acid by Bacteria of Bacillus Genus

Transferrin conjugated poly (γ-glutamic acid-maleimide-co- l -lactide)-1,2-dipalmitoylsn-glycero-3-phosphoethanolamine copolymer nanoparticles for targeting drug delivery

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