Protein tyrosine phosphatase controls breast cancer invasion through the expression of matrix metalloproteinase-9

Hwang, Bomi; Chae, Hee Suk; Jeong, Young-Ju; Lee, Young‐Rae; Noh, Eun‐Mi; Youn, Hyun Zo; Jung, Sung Hoo; Yu, Hong‐Nu; Chung, Eun Yong; Kim, Jong‐Suk

doi:10.5483/bmbrep.2013.46.11.053

Cited by 17 publications

(10 citation statements)

References 29 publications

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“…MMPs are members of the metzincin superfamily which comprises zinc-and calciumdependent enzymes comprising more than 24 subtypes (118). It is widely accepted that MMPs mediate degradation and modify most components of the extracellular matrix (ECM) and the basal membrane (BM), which is critical for cancer invasion and metastasis (119)(120)(121). As one of the most important MMP genes, the MMP-13 gene, also known as collagenase-3, is located in chromosome 11q22, spanning approximately 12.5 kb and consists of ten exons and nine introns (122).…”

Section: Contents Of Npc-derived-evsmentioning

confidence: 99%

The biology and function of extracellular vesicles in nasopharyngeal carcinoma (Review)

et al. 2017

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Extracellular vesicles are a heterogeneous group of membrane-enclosed vesicles, which play an important role in intercellular communication. Increasing number of studies have shown that tumor-derived extracellular vesicles might be involved in the transfer of oncogenic cargo (proteins, lipids, messenger RNA, microRNA, non-coding RNAs and DNA) through which cancer cells could shape the tumor microenvironment and influence tumor progression. Nasopharyngeal carcinoma-derived extracellular vesicles have also reported to facilitate tumor proliferation, metastasis and immune escape. Moreover, nasopharyngeal carcinoma-derived extracellular vesicles might serve as biomarkers for early diagnosis and therapeutic targets. The present review provides information on the biological and clinical significance of extracellular vesicles in tumors, especially in nasopharyngeal carcinoma.

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Section: Contents Of Npc-derived-evsmentioning

confidence: 99%

The biology and function of extracellular vesicles in nasopharyngeal carcinoma (Review)

et al. 2017

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“…MDA-MB-231, Hs578T, and MCF7 cells were cultured as described. 36 Cell lines were authenticated by the Korean Cell Line Bank using STR-PCR analysis.…”

Section: Cell Lines and Culture Conditionsmentioning

confidence: 99%

Discoidin domain receptor 1 is a novel transcriptional target of ZEB1 in breast epithelial cells undergoing H‐Ras‐induced epithelial to mesenchymal transition

Koh

Woo

Valiathan

et al. 2014

Intl Journal of Cancer

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The epithelial-to-mesenchymal transition (EMT) process allows carcinoma cells to dissociate from the primary tumor thereby facilitating tumor cell invasion and metastasis. Ras-dependent hyperactive signaling is commonly associated with tumorigenesis, invasion, EMT, and metastasis. However, the downstream effectors by which Ras regulates EMT remain ill defined. In this study, we show that the H-Ras pathway leads to mesenchymal-like phenotypic changes in human breast epithelial cells by controlling the ZEB1/microRNA–200c axis. Moreover, H-Ras suppresses the expression of the discoidin domain receptor 1 (DDR1), a collagen receptor tyrosine kinase, via ZEB1, thus identifying ZEB1 as a novel transcriptional repressor of DDR1. Mutation studies on the putative promoter of the DDR1 gene revealed that bipartite Z- and E-box elements play a key role in transcriptional repression of DDR1 in Hs578T and MDA-MB-231 breast carcinoma cell lines by ZEB1. Furthermore, we found an inverse correlation between ZEB1 and DDR1 expression in various cancer cell lines and in human breast carcinoma tissues. Consistently, overexpression of DDR1 reduced the invasive phenotype of mesenchymal-like triple-negative breast cancer cells in 3D cultures and in vivo. Thus, ZEB1’s role in maintenance of EMT in breast carcinoma cells is mediated in part by its ability to suppress DDR1 expression and consequently contribute to the activation of the invasive phenotype. Taken together, our results unveil a novel H-Ras/ZEB1/DDR1 network that contributes to breast cancer progression in triple-negative breast cancers.

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“…30,31 A study conducted by Benson et al 32 evaluated the expression of MMPs in different types of tissues with breast cancer and normal tissues. The results showed that MMPs are regulated differentially in tissues with breast neoplasm.…”

Section: Zinc and Metalloproteinases Of The Extracellular Matrixmentioning

confidence: 99%

Zinc and metalloproteinases 2 and 9: What is their relation with breast cancer?

Holanda

Oliveira²,

Cruz³

et al. 2017

Rev. Assoc. Med. Bras.

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Zinc is the catalytic component of proteins that regulate responses to DNA damage, intracellular signaling enzymes, and matrix metalloproteinases, which are important proteins in carcinogenesis. The objective of this review is to bring current information on the participation of zinc and matrix metalloproteinases types 2 and 9 in mechanisms involved in the pathogenesis of breast cancer. We conducted a literature review, in consultation with the PubMed, Lilacs, and Scielo databases. The zinc and cysteine residues are structural elements shared by all members of the family of matrix metalloproteinases, and these proteins appear to be involved in the propagation of various types of neoplasms, including breast cancer. Moreover, transported zinc is likely to be used for the metalation of the catalytic domain of the newly synthesized metalloproteinases before the latter are secreted. Accordingly, increase in zinc concentrations in cellular compartments and the reduction of this trace element in the blood of patients with breast cancer appear to alter the activity of metalloproteinases 2 and 9, contributing to the occurrence of malignancy. Thus, it is necessary to carry out further studies with a view to clarify the role of zinc and metalloproteinases 2 and 9 in the pathogenesis of breast cancer.

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Protein tyrosine phosphatase controls breast cancer invasion through the expression of matrix metalloproteinase-9

Cited by 17 publications

References 29 publications

The biology and function of extracellular vesicles in nasopharyngeal carcinoma (Review)

The biology and function of extracellular vesicles in nasopharyngeal carcinoma (Review)

Discoidin domain receptor 1 is a novel transcriptional target of ZEB1 in breast epithelial cells undergoing H‐Ras‐induced epithelial to mesenchymal transition

Zinc and metalloproteinases 2 and 9: What is their relation with breast cancer?

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