Off-label-Indikationen für topisches Tacrolimus

Hengge, Ulrich R.

doi:10.1007/s00105-013-2594-1

Cited by 9 publications

(7 citation statements)

References 18 publications

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“…As there are numerous clues to the autoimmune nature of the disease, the role of topical immunomodulatory drugs, calcineurine inhibitors, such as tacrolimus has been investigated in vitiligo . It inhibits calcineurin action, thus preventing T‐cell activation and the production of various inflammatory cytokines . The efficacy and safety of tacrolimus ointment were reported in the treatment of childhood vitiligo with mild side effects …”

Section: Introductionmentioning

confidence: 99%

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Comparison between the efficacy of microneedling combined with 5‐fluorouracil vs microneedling with tacrolimus in the treatment of vitiligo

Mina

Elgarhy

Al-saeid

et al. 2018

J of Cosmetic Dermatology

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Section: Introductionmentioning

confidence: 99%

“…8 It inhibits calcineurin action, thus preventing T-cell activation and the production of various inflammatory cytokines. 9 The efficacy and safety of tacrolimus ointment were reported in the treatment of childhood vitiligo with mild side effects. 10…”

mentioning

confidence: 99%

Comparison between the efficacy of microneedling combined with 5‐fluorouracil vs microneedling with tacrolimus in the treatment of vitiligo

Mina

Elgarhy

Al-saeid

et al. 2018

J of Cosmetic Dermatology

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“…Both have been used to treat other inflammatory and immunologic skin disorders, including vitiligo, with encouraging results. 4 , 5 …”

Section: Introductionmentioning

confidence: 99%

Effectiveness and safety of topical tacrolimus monotherapy for repigmentation in vitiligo: a comprehensive literature review

Sisti

Oranges

2016

An. Bras. Dermatol.

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Thus far, several small studies and case reports on the use of topical immunomodulators in vitiligo have been published. We undertook a comprehensive literature review, searching for studies evaluating clinical response to tacrolimus topical therapy for vitiligo. A search was performed on PubMed/Medline using the term “vitiligo”, combined with “topical” and “ointment”. Our inclusion criteria were: use of tacrolimus ointment as monotherapy to treat vitiligo. We found 29 studies from 2002 to 2014. Overall, 709 patients were treated in 29 studies. Pooling the lesions, 50% repigmentation of vitiligo patches was never achieved before 2 months of treatment, with a peak after 6 months of therapy. The best results were obtained on lesions of the cephalic region, especially the face, with tacrolimus 0.1% ointment two times daily. The percentage of non-responsive patients ranged from 0% to 14%. Treatment was generally well-tolerated; only localized adverse effects were reported. Our objective was to verify the effectiveness and safety of tacrolimus ointment monotherapy. It has good efficacy and tolerability. At present, only small trials and case series are available in the literature. Further, standardized investigations on a larger number of patients are needed.

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“…Bei erosiv-nässenden Prozessen der Perianalhaut können neben der seifenfreien Analreinigung mit lauwarmem Wasser auch zusätzliche Sitzbäder mit synthetischen Gerbstoffen (Tannolact ® , Tannosynt ® ) empfohlen werden. Nach Rückgang der gelegentlich nässenden, entzündlichen Hautveränderungen erweist sich die Anwendung von topischen Calcineurinantagonisten, wie Pimecrolimus oder Tacrolimus (Elidel ® , Protopic ® ), als äußerst wirkungsvoll [1,4,6,11]. Eine solche Applikation wird im Akutstadium wegen starken Brennens häufig noch nicht toleriert.…”

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Systematik und Therapie des Analekzems

Lenhard

2016

Akt Dermatol

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Zusammenfassung Das Analekzem z?hlt zu den h?ufigsten proktologischen Erkrankungen. Entsprechend der ?tiopathogenese unterscheidet man drei Ekzemformen, die sich gelegentlich auch ?berschneiden k?nnen. In der Reihenfolge der Auftretensh?ufigkeit beobachtet man das irritativ-toxische, das atopische und das kontaktallergische Ekzem. Eine m?glichst sichere Zuordnung bestimmt letztlich den Therapieerfolg. Proktologische Grunderkrankungen wirken verursachend und als Triggerfaktor. Ihrer Diagnose und Therapie kommt deshalb hohe Bedeutung zu. Neben basistherapeutischen Ma?nahmen und kurzzeitiger Anwendung von Kortikosteroiden gewinnt die Applikation von Calcineurinantagonisten in der Therapie perianaler Ekzeme zunehmend an Bedeutung. Diagnostische Unklarheit, Therapieresistenz und Progredienz fordern eine histopathologische Kl?rung.

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Off-label-Indikationen für topisches Tacrolimus

Cited by 9 publications

References 18 publications

Comparison between the efficacy of microneedling combined with 5‐fluorouracil vs microneedling with tacrolimus in the treatment of vitiligo

Comparison between the efficacy of microneedling combined with 5‐fluorouracil vs microneedling with tacrolimus in the treatment of vitiligo

Effectiveness and safety of topical tacrolimus monotherapy for repigmentation in vitiligo: a comprehensive literature review

Systematik und Therapie des Analekzems

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