Boron nitride nanotubes coated with organic hydrophilic agents: Stability and cytocompatibility studies

Ferreira, Tiago Hilário; Soares, Daniel Crístian Ferreira; Moreira, Luciana Mara Costa; Silva, Paulo Roberto Ornelas da; Santos, Raquel Gouvêa dos; Sousa, Edésia Martins Barros de

doi:10.1016/j.msec.2013.07.024

Cited by 40 publications

(21 citation statements)

References 38 publications

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“…The cell viability was more than 80% in all the studied concentrations, indicating no adverse effects on HeLa cultures in terms of metabolic activity after the incubation time. This result is in accordance with others studies that show the good biocompatibility of BNNTs up to 200 μg/mL [10,32,33]. …”

Section: Resultssupporting

confidence: 93%

An Assessment of the Potential Use of BNNTs for Boron Neutron Capture Therapy

et al. 2017

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Currently, nanostructured compounds have been standing out for their optical, mechanical, and chemical features and for the possibilities of manipulation and regulation of complex biological processes. One of these compounds is boron nitride nanotubes (BNNTs), which are a nanostructured material analog to carbon nanotubes, but formed of nitrogen and boron atoms. BNNTs present high thermal stability along with high chemical inertia. Among biological applications, its biocompatibility, cellular uptake, and functionalization potential can be highlighted, in addition to its eased utilization due to its nanometric size and tumor cell internalization. When it comes to new forms of therapy, we can draw attention to boron neutron capture therapy (BNCT), an experimental radiotherapy characterized by a boron-10 isotope carrier inside the target and a thermal neutron beam focused on it. The activation of the boron-10 atom by a neutron generates a lithium atom, a gamma ray, and an alpha particle, which can be used to destroy tumor tissues. The aim of this work was to use BNNTs as a boron-10 carrier for BNCT and to demonstrate its potential. The nanomaterial was characterized through XRD, FTIR, and SEM. The WST-8 assay was performed to confirm the cell viability of BNNTs. The cells treated with BNNTs were irradiated with the neutron beam of a Triga reactor, and the apoptosis caused by the activation of the BNNTs was measured with a calcein AM/propidium iodide test. The results demonstrate that this nanomaterial is a promising candidate for cancer therapy through BNCT.

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Section: Resultssupporting

confidence: 93%

An Assessment of the Potential Use of BNNTs for Boron Neutron Capture Therapy

et al. 2017

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“…Over the latest few years, several studies have been carried out to evaluate the effects of BNNTs in vitro (Ciofani et al, 2010(Ciofani et al, , 2008cFerreira et al, 2013;Horváth et al, 2011;Lahiri et al, 2010) and in vivo (Soares et al, 2011). Despite of some discrepancies in obtained results because of different experimental approaches due to the intrinsic complexity of the nanomaterials, most of results indicated very good response of cells and organisms toward BNNTs.…”

Section: Introductionmentioning

confidence: 99%

Folate-grafted boron nitride nanotubes: Possible exploitation in cancer therapy

Ferreira

Marino

Rocca

et al. 2015

International Journal of Pharmaceutics

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“…In another study, the glycol-chitosan (GC) non-covalently coated BNNTs exposed human neuroblastoma SH-SY5Y cells were viable up to100 g/mL of GC-BNNTs [16]. In another study, the BNNTs were functionalized with organic hydrophilic agents including glucosamine (GA), poly(ethylene glycol) 1000 (PEG 1000 ) and chitosan (CH), and their toxicity was investigated [17]. The study found that the PEG 1000 -BNNT and CH-BNNT were cytotoxic at high concentrations (100 g/mL) while the GA-BNNT was not cytotoxic.…”

Section: Introductionmentioning

confidence: 99%