Mineralization in calcified plaque is like that of cortical bone—Further evidence from ultrashort echo time (UTE) magnetic resonance imaging of carotid plaque calcification and cortical bone

Du, Jiang; Peterson, Michael R.; Kansal, Nikhil; Bydder, Graeme M.; Kahn, Andrew

doi:10.1118/1.4819944

Cited by 10 publications

(9 citation statements)

References 48 publications

(69 reference statements)

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“…Thus, to completely replace the need for a planning CT, UTE MRI must be able to adequately depict these calcifications in the brain. It was recently shown that calcified arterial plaque appears very similar to cortical bone on UTE images, 40 which suggests that calcified brain lesions might be identifiable using the same techniques appropriate for cranial bone segmentation. In the present study, we could not acquire UTE MR images while the skull phantom was positioned in the MRgFUS system because our UTE pulse sequence was developed on a different MR scanner platform.…”

Section: Discussionmentioning

confidence: 98%

Ultrashort echo‐time MRI versus CT for skull aberration correction in MR‐guided transcranial focused ultrasound: In vitro comparison on human calvaria

et al. 2015

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The authors have demonstrated that transcranial focal heating can be significantly improved in vitro by using UTE MRI to compute skull-induced ultrasound aberration corrections. Their results suggest that UTE MRI could be used instead of CT to implement such corrections on current 0.7 MHz clinical TcMRgFUS devices. The MR image acquisition and segmentation procedure demonstrated here would add less than 15 min to a clinical MRgFUS treatment session.

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Section: Discussionmentioning

confidence: 98%

Ultrashort echo‐time MRI versus CT for skull aberration correction in MR‐guided transcranial focused ultrasound: In vitro comparison on human calvaria

et al. 2015

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“…Specific MRI sequences, such as UTE, SWI, or DESS, were among the candidate items retained after item reduction, but in subsequent discussions were felt to be on the future research agenda for CPPD and not ready for routine clinical use nor for inclusion in CPPD classification criteria (24)(25)(26)42). Recently, UTE and SWI MRI have shown promise for the identification and quantification of calcium crystal deposition in and around joints as well as other anatomical sites (24,25,43,44).…”

Section: Discussionmentioning

confidence: 99%

Imaging Features of Calcium Pyrophosphate Deposition Disease: Consensus Definitions From an International Multidisciplinary Working Group

Tedeschi

Becce

Pascart

et al. 2022

Arthritis Care & Research

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Objective. To develop definitions for imaging features being considered as potential classification criteria for calcium pyrophosphate deposition (CPPD) disease, additional to clinical and laboratory criteria, and to compile example images of CPPD on different imaging modalities.Methods. The American College of Rheumatology and European Alliance of Associations for Rheumatology CPPD classification criteria Imaging Advisory Group (IAG) and Steering Committee drafted definitions of imaging features that are characteristic of CPPD on conventional radiography (CR), conventional computed tomography (CT), dual-energy CT (DECT), and magnetic resonance imaging (MRI). An anonymous expert survey was undertaken by a 35-member Combined Expert Committee, including all IAG members. The IAG and 5 external musculoskeletal radiologists with expertise in CPPD convened virtually to further refine item definitions and voted on example images illustrating CR, CT, and DECT item definitions, with ≥90% agreement required to deem them acceptable.Results. The Combined Expert Committee survey indicated consensus on all CR definitions. The IAG and external radiologists reached consensus on CT and DECT item definitions, which specify that calcium pyrophosphate deposits appear less dense than cortical bone. The group developed an MRI definition and acknowledged limitations of this modality for CPPD. Ten example images for CPPD were voted acceptable (4 CR, 4 CT, and 2 DECT), and 3 images of basic calcium phosphate deposition were voted acceptable to serve as contrast against imaging features of CPPD.Conclusion. An international group of rheumatologists and musculoskeletal radiologists defined imaging features characteristic of CPPD on CR, CT, and DECT and assembled a set of example images as a reference for future clinical research studies.

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“…However, recent advancement of MR technologies has enabled the application of ultrashort TE (UTE) MRI for routine clinical use. UTE MRI with 3D radial sampling of the free induction decay allows for the depiction of "solidstate" tissues or objects with very short T2 as bright signals, which help depict tendons, ligaments, menisci, [20][21][22] periosteum, 23 renal stones, 24 carotid plaque, [25][26] etc. Subtraction between two echoes during T2 decay makes the short T2 properties of the solid state stones more conspicuous.…”

Section: Introductionmentioning

confidence: 99%

Three Dimensional Ultra-short Echo Time MRI Can Depict Cholesterol Components of Gallstones Bright

Takahashi

Takehara

Fujisaki³

et al. 2021

magn reson med sci

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Purpose Non-calcified cholesterol stones that are small in size are hard to be depicted on CT or magnetic resonance cholangiopancreatography. This institutional review board (IRB)-approved retrospective in vitro study aims to characterize contrast behaviors of 3 main components of the gallstones, i.e., cholesterol component (CC), bilirubin calcium component (BC) and CaCO 3 (CO) on 3D radial scan with ultrashort TE (UTE) MRI, and to test the capability of depicting CC of gallstones as bright signals as compared to background saline. Methods Fourteen representative gallstones from 14 patients, including 15 CC, 6 BC and 4 CO, were enrolled. The gallstones underwent MRI including fat-saturated T1-weighted image (fs-T1WI) and UTE MRI with dual echoes. The contrast-to-noise ratio (CNR) and the chemical analysis for the 25 portions of the stones were compared. Results BC was bright on fs-T1WI, which did not change dramatically on UTE MRI and the signal did not remain on UTE subtraction image between dual echoes. Whereas the CC was negative or faintly positive signal on fs-T1WI, bright signal on UTE MRI and the contrast remained even higher on the UTE subtraction, which reflected their short T2 values. Median CNRs and standard errors of the segments on each imaging were as follows: on fs-T1WI, −10.2 ± 4.2 for CC, 149.7 ± 27.6 for BC and 37.9 ± 14.3 for CO; on UTE MRI first echo, 16.7 ± 3.3 for CC, 74.9 ± 21.3 for BC and 17.7 ± 8.4 for CO; on UTE subtraction image, 30.2 ±2.0 for CC, −11.2 ± 5.4 for BC and 17.8 ± 10.7 for CO. Linear correlations between CNRs and cholesterol concentrations were observed on fs-T1WI with r = −0.885, ( P < 0.0001), UTE MRI first echo r = −0.524 ( P = 0.0072) and UTE subtraction with r = 0.598 ( P = 0.0016). Conclusion UTE MRI and UTE subtraction can depict CC bright.

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Mineralization in calcified plaque is like that of cortical bone—Further evidence from ultrashort echo time (UTE) magnetic resonance imaging of carotid plaque calcification and cortical bone

Abstract: CPC bears remarkable similarities with cortical bone in terms of BMD and T1. CPC shows a higher mean T2* and a lower mean water concentration.

Cited by 10 publications

References 48 publications

Ultrashort echo‐time MRI versus CT for skull aberration correction in MR‐guided transcranial focused ultrasound: In vitro comparison on human calvaria

Ultrashort echo‐time MRI versus CT for skull aberration correction in MR‐guided transcranial focused ultrasound: In vitro comparison on human calvaria

Imaging Features of Calcium Pyrophosphate Deposition Disease: Consensus Definitions From an International Multidisciplinary Working Group

Three Dimensional Ultra-short Echo Time MRI Can Depict Cholesterol Components of Gallstones Bright

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