Involucrin in the differential diagnosis between linear psoriasis and inflammatory linear verrucous epidermal nevus: a report of one case

Ferreira, Flávia Regina; Chiacchio, Nilton Gioia Di; Alvarenga, Marcia Lanzoni de; Mandelbaum, Samuel Henrique

doi:10.1590/abd1806-4841.20131733

Cited by 8 publications

(15 citation statements)

References 16 publications

(14 reference statements)

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“…Underexpression of keratin 5 in VLX was in fact associated with a decrease in p63 expression in the basal layer, while keratin 5 expression in the spinous layer in HPX was associated with an increase in p63 expression (Figure a). Likewise, increased involucrin expression in HPX was also associated with increased p63, as noted in psoriasis (Ferreira, Chiacchio, Alvarenga, & Mandelbaum, ; Shen, Tsuda, Fushiki, Mizutani, & Yamanishi, ). Phosphorylated p38 regulates both epidermal differentiation by regulating involucrin (Eckert et al, ) and pigmentation via induction of MITF and USF1 (Corre et al, ).…”

Section: Resultsmentioning

confidence: 78%

Epidermal keratin 5 expression and distribution is under dermal influence

Cario‐André

Pain

Kaulanjan-Checkmodine

et al. 2019

Pigment Cell Melanoma Res

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Human skin melanin pigmentation is regulated by systemic and local factors. According to the type of melanin produced by melanocytes, the transfer and degradation of melanosomes differ, thus accounting for most variations between ethnicities. We made the surprising observation that in a drastically changed environment, white and black phenotypes are reversible since Caucasian skin grafted onto nude mice can become black with all black phenotypic characteristics. Black xenografts differed essentially from other grafts by the levels of epidermal FGF‐2 and keratin 5. In vitro analysis confirmed that FGF‐2 directly regulates keratin 5. Interestingly, this phenomenon may be involved in human pathology. Keratin 5 mutations in Dowling–Degos Disease (DDD) have already been associated with the pheomelanosome–eumelanosome transition. In a DDD patient, keratin 5 was expressed in the basal and spinous layers, as observed in black xenografts. Furthermore, in a common age‐related hyperpigmentation disorder like senile lentigo (SL), keratin 5 distribution is also altered. In conclusion, modulation of keratin 5 expression and distribution either due to mutations or factors may account for the development of pigmentary disorders.

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Section: Resultsmentioning

confidence: 78%

Epidermal keratin 5 expression and distribution is under dermal influence

Cario‐André

Pain

Kaulanjan-Checkmodine

et al. 2019

Pigment Cell Melanoma Res

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“…Under these circumstances, immunohistochemical studies are helpful in distinguishing these two cutaneous disorders. For example, involucrin is a marker whose expression is absent in the parakeratotic areas of ILVEN but present in psoriasis [6]. Moreover, the number of Ki-67 positive nuclei is higher in psoriasis compared to ILVEN, while the number of keratin-10 positive cells is higher in ILVEN [7].…”

Section: Case Discussionmentioning

confidence: 99%

The Successful Treatment of a Case of Linear Psoriasis with Ixekizumab

Ghoneim¹,

Ramos‐Rodriguez

Lara

et al. 2017

Case Reports in Dermatological Medicine

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Linear psoriasis is an unusual clinical variation of psoriasis that manifests segmentally along the lines of Blaschko. A major differential diagnosis is inflammatory linear verrucous epidermal nevus (ILVEN). The treatment of linear psoriasis is often challenging, with inadequate response to biological agents reported in the literature. We report a case of a 25-year-old AfricanAmerican female who presented with asymptomatic hyperkeratotic papules along the lines of Blaschko and was subsequently diagnosed with linear psoriasis. After failing conventional treatment regimens, the patient received a trial of ixekizumab with complete resolution of cutaneous lesions reported after 4 months and only 8 doses of the anti-IL-17 biologic agent.

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“…The rash of linear psoriasis usually has mild pruritus or no symptoms. 5,6 It is interesting to note that several reported cases of linear psoriasis in the literature also revealed a tendency to involve the left side of the body. 3,7 Previously reported cases of linear psoriasis showed wide, band-like linear lesions, however, the rash on this patient showed a very narrow linear distribution similar to ILVEN or epidermal nevus.…”

Section: Introductionmentioning

confidence: 98%

“…It is crosslinked to other membrane proteins and contributes to the formation of the cornified cell envelope. 5 While it is present in the upper portion of the spinous and granular layer of the normal epidermis, it is expressed in the subbasal layer in psoriasis. In ILVEN, transglutaminase expression is increased in areas of the orthokeratosis but decreased in areas of parakeratosis .…”

Section: Introductionmentioning

confidence: 99%

“…In ILVEN, transglutaminase expression is increased in areas of the orthokeratosis but decreased in areas of parakeratosis . 5 Furthermore, ILVEN is refractory to antipsoriatic treatment, whereas linear psoriasis responds well to topical DISCUSSION antipsoriatic agents or narrow-band UVB phototherapy. 11 In summary, we report a rare case of unilateral linear psoriasis involving the lower leg of a 71-year-old female, and discuss the clinical, histological features of the lesion, and the most common differential diagnosis.…”

Section: Introductionmentioning

confidence: 99%

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Linear Psoriasis: A Case Report of a 71-Year-Old Female

Chen²,

Sapadin³

et al. 2018

J of Skin

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A 71-year-old woman presented to the clinic with a one-month history of pruritic, burning, flaky pink to dark red erythematous plaques. The lesions had a very narrow, linear, Blashkoid distribution which extended from the left lateral sole to the popliteal region ( Figure 1). The right leg also had a similar erythematous plaque located at the pretibial region. The patient had no other lesions or previous history of psoriasis. Punch biopsies were performed which revealed orthokeratosis and mounds of parakeratosis, and traumatized Koebnerization. Elongation of rete ridges was not prominent, however, mild psoriasiform hyperplasia and suprapapillary thinning of the epidermis with mildly increased vessels in the dermal papillae and a lymphocytic infiltrate in the upper dermis were observed. (Figure 2A-D). The findings were consistent with features of an early psoriasis lesion.PAS and the direct immunofluorescence (DIF) stains were negative, but Ki-67 showed increased expression ( Figure 2E). Together with the clinical presentation, a diagnosis of linear psoriasis was favored. ABSTRACTA 71-year-old woman presented with a one-month history of pruritus, burning, flaky, and erythematous plaques. The lesions had a very narrow lineal distribution, extending from the lateral left sole to the left popliteal region. Microscopically, the skin biopsy sample revealed orthokeratosis, parakeratosis and traumatized Koebnerization. Elongation of rete ridges was not prominent. The patient had a good clinical response to oral prednisone. Linear psoriasis is a rare variant of psoriasis of unknown etiology. Approximately 23 reports have been published in the English literature. The main differential diagnosis is Inflammatory linear verrucous epidermal nevus (ILVEN). Thorough clinicopathologic findings and response to treatment are all required in the diagnosis and management of this rare form of psoriasis. CASE REPORT

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Involucrin in the differential diagnosis between linear psoriasis and inflammatory linear verrucous epidermal nevus: a report of one case

Cited by 8 publications

References 16 publications

Epidermal keratin 5 expression and distribution is under dermal influence

Epidermal keratin 5 expression and distribution is under dermal influence

The Successful Treatment of a Case of Linear Psoriasis with Ixekizumab

Linear Psoriasis: A Case Report of a 71-Year-Old Female

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