The Successful Treatment of a Case of Linear Psoriasis with Ixekizumab

Ghoneim, Sara; Ramos‐Rodriguez, Alvaro J.; Lara, Fernando Vazquez de; Bonomo, L

doi:10.1155/2017/3280215

Cited by 3 publications

(6 citation statements)

References 12 publications

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“…There are at least two case reports of patients presenting with overlapping features of ILVEN and linear psoriasis that responded to treatments with a TNF‐ inhibitor, etanercept, 20 and IL‐17a inhibitor, ixekizumab 13 . Tanita et al reported a case of wide‐spread unilateral ILVEN that clinically and histologically mimicked psoriasis vulgaris but was distinguishable by immunohistochemical staining focused on the IL‐36γ/IL‐17a axis 21 .…”

Section: Discussionmentioning

confidence: 99%

“…Reported treatments for ILVEN include topical steroids, 4 topical tretinoin and 5-fluorouracil, 5 topical calcipotriene, 6,7 pulsed dye laser, 8 CO2 laser, 9 excimer laser, 4 surgical excision, 10,11 TNF-inhibitors 12 and IL-17a inhibitors. 13 Many of these treatments are derived from the psoriasis literature as some believe that the two entities share a common pathogenesis. 14,15 Clinically, both linear psoriasis and ILVEN can present as psoriasiform linear plaques.…”

Section: Discussionmentioning

confidence: 99%

“…19 There are at least two case reports of patients presenting with overlapping features of ILVEN and linear psoriasis that responded to treatments with a TNF-inhibitor, etanercept, 20 and IL-17a inhibitor, ixekizumab. 13 Tanita et al reported a case of wide-spread unilateral ILVEN that clinically and histologically mimicked psoriasis vulgaris but was distinguishable by immunohistochemical staining focused on the IL-36γ/IL-17a axis. 21 They showed that while lesional skin of both entities possessed IL-36R cells, the expression of IL-36γ was decreased on the epidermal keratinocytes in ILVEN compared with that in psoriasis lesions.…”

Section: Discussionmentioning

confidence: 99%

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A case of inflammatory linear verrucous epidermal nevus successfully treated with Brodalumab

Green

Hunter

Chia

2022

Pediatric Dermatology

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Inflammatory linear verrucous epidermal nevus (ILVEN) is a rare type of epidermal nevus, commonly arising in childhood. We present a case of a 13‐year‐old female with Blaschkoid psoriasiform plaques extending from her left foot to the scalp, sparing the right side of the body. While treatment options historically show variable success, we trialed an IL‐17a receptor inhibitor as studies have shown increased levels of IL‐17 receptor expression in ILVEN keratinocytes. At both 3 and 6 months after treatment initiation there was found to be significant improvement. We propose brodalumab as an effective treatment option for widespread ILVEN.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A case of inflammatory linear verrucous epidermal nevus successfully treated with Brodalumab

Green

Hunter

Chia

2022

Pediatric Dermatology

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“…Ustekinumab (interleukin 12/23) was also used in a linear psoriasis case reported by Weng and Tsai [ 18 ] after the patient failed to respond to methotrexate, acitretin, topical vitamin D 3 analogs, and steroids. Recently, Ghoneim et al [ 19 ] reported a case of a patient with linear psoriasis started on ixekizumab (interleukin 17), after failing to respond to topical steroids. After 4 months and 8 doses, the patient showed marked improvement, with the skin lesions almost resolved [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…Recently, Ghoneim et al [ 19 ] reported a case of a patient with linear psoriasis started on ixekizumab (interleukin 17), after failing to respond to topical steroids. After 4 months and 8 doses, the patient showed marked improvement, with the skin lesions almost resolved [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Successful Treatment of Inflammatory Linear Verrucous Epidermal Nevus with Concomitant Psoriasis Using Etanercept

et al. 2018

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Linear psoriasis is a rare form of the disease characterized by the linear distribution of lesions involving dermatome or along Blaschko’s lines. Clinically, it may resemble inflammatory linear verrucous epidermal nevus; a combination of history, skin examination, and histopathology are required to ensure correct diagnosis and appropriate therapy. This paper describes a case of a 23-year-old male presenting with unilateral erythematous scaly plaques arranged in a linear path on the left leg. Etanercept was initiated after poor response to adalimumab. Improvement of his psoriasis was noted, with PASI 75 reduction after 24 weeks of treatment. Clinical studies have shown excellent efficacy of etanercept, and our patient well tolerated treatment with etanercept for 52 weeks without any adverse effects.

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Clinical Characteristics and Therapeutic Aspects of Blaschko Linear Psoriasis

Chen,

Cheng,

Peng

et al. 2024

Dermatol Ther (Heidelb)

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Introduction Blaschko linear psoriasis (BLP) is characterized by the linear distribution of psoriatic skin lesions along the Blaschko lines. BLP can be divided into type I and type II, mainly on the basis of clinical manifestations. BLP can easily cause psychological burdens in patients and clinical confusion for physicians. Here, we summarize clinical cases to provide a better understanding of BLP. Methods The subjects included patients with BLP who visited our dermatology departments and those reported in the literature obtained from the PubMed and Wanfang databases. Quantitative data were presented as means ± SD (standard deviation), and qualitative data were represented by the frequency. Student’s t test was employed to compare means, whereas chi-square tests were used for analyzing qualitative data. Results A total of 74 patients with BLP (5 our patients, 69 from literature) were included, with 61 type I and 13 type II patients. We summarize BLP’s characteristics as follows: (1) More frequent in male individuals, especially in type II; (2) Earlier onset than classical psoriasis; (3) Mainly distributed unilaterally, and no preference for left or right site; (4) Asymptomatic or slight pruritus; (5) Mostly negative family history of psoriasis; (6) Possible involvement of the nails/scalp (mainly for type II); (7) Possible exogenous triggering or aggravation factors; (8) Possible concomitant classical plaque or guttate psoriasis lesions, especially in type II; (9) Conforming to histopathology features of classical psoriasis; (10) Relatively favorable response to antipsoriatic treatment, although poor for superimposed areas in type II. Conclusion This study analyzed the clinical characteristics and therapeutic aspects of BLP. Compared with published studies, we have new findings, such as gender bias. Besides traditional antipsoriatic treatment, a personalized selection of biologics may also be a promising choice. Dermatologists should recognize and understand the significance of this disease, and provide patients with appropriate psychological counseling and clinical treatments. Supplementary Information The online version contains supplementary material available at 10.1007/s13555-024-01140-0.

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The Successful Treatment of a Case of Linear Psoriasis with Ixekizumab

Cited by 3 publications

References 12 publications

A case of inflammatory linear verrucous epidermal nevus successfully treated with Brodalumab

A case of inflammatory linear verrucous epidermal nevus successfully treated with Brodalumab

Successful Treatment of Inflammatory Linear Verrucous Epidermal Nevus with Concomitant Psoriasis Using Etanercept

Clinical Characteristics and Therapeutic Aspects of Blaschko Linear Psoriasis

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