Reduction of carrageenan-induced acute pulmonary inflammation in mice by novel thiazolidinedione derivative LPSF/RA-4

Diethylcarbamazine inhibits NF-κB activation in acute lung injury induced by carrageenan in mice

“…Pleurisy experiments were carried out as previously described [16]. Mice were anesthetized intramuscularly with a combination of 10% ketamine hydrochloride (115 mg/kg) and xylazine 2% (10 mg/kg).…”

Diethylcarbamazine Attenuates the Development of Carrageenan-Induced Lung Injury in Mice

“…The inflammatory process is invariably characterized by the production of prostaglandin, leukotrienes, histamine, bradykinin, platelet-activating factor, interleukins (IL), and migrating cells [10]. The recruitment of polymorphonuclear cells (PMNs) from the circulation to the inflamed tissue has a key function in the breakdown and remodeling of injured tissue [11, 12]. Moreover, macrophages participate in the progression of experimental pleurisy by producing proinflammatory cytokines, such as tumor necrosis factor- α (TNF α ) and IL-1 β [13].…”