Variations in the Levels of Mulberroside A, Oxyresveratrol, and Resveratrol in Mulberries in Different Seasons and during Growth

Zhou, Jin; Li, Shunxiang; Wang, Wei; Guo, Xiaoyi; Xiang-yang, LU; Yan, Xinpei; Huang, Dan; Wei, Baoyang; Cao, Liang

doi:10.1155/2013/380692

Cited by 37 publications

(32 citation statements)

References 16 publications

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“…In recent years, the potential uses of the Oxy‐Res in noncommunicable diseases such as diabetes mellitus, Parkinson's disease, and cardiovascular illnesses have been explored . However, the antitumor effect of Oxy‐Res has seldom been reported . Although there are many potential applications, the officially clinical use of the Oxy‐Res has been greatly limited because the molecular target of Oxy‐Res was not clear.…”

Section: Introductionmentioning

confidence: 99%

Toxic trans‐crotonaldehyde in mitochondria intercepted by oxyresveratrol contributing to anticancer

Sun

Chen

et al. 2019

IUBMB Life

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The aim of this study was to explore how the toxic trans‐crotonaldehyde (TCA) in mitochondria or aldehyde dehydrogenase (ALDH) at different pHs was intercepted by oxyresveratrol (Oxy‐Res) contributing to anticancer. Ultraviolet–visible (UV–vis) spectroscopy and Raman spectroscopy were employed. UV–vis spectra showed that the Oxy‐Res red shifted the peak of the toxic TCA from 316 nm to 325 nm, while the peaks of the Oxy‐Res shifted from 329 nm with 290 nm and 300 nm to 325 nm with 303 nm. In the mitochondria, the Oxy‐Res blue shifted the peaks of the toxic TCA from 325 nm with 303 nm to 321 nm with 301 nm. Raman spectra revealed that the Oxy‐Res caused shifting of the CHO of the toxic TCA from 1,689 cm−1 to 1,671 cm−1 with band decline. The CC of the toxic TCA at 1641 cm−1 was split into 1,639 cm−1 and 1,642 cm−1 with band decline. The bands of the Oxy‐Res at 1634 cm−1, 1,617 cm−1, and 1,595 cm−1 disappeared. In the mitochondria, the CC of the toxic TCA at 1641 cm−1 splitting disappeared. In ALDH, with the decrease of pH from 7.8 to 6.5, the CHO of the toxic TCA did not red shift from 1,689 cm−1 to 1,674 cm−1 up to pH 6.5. There was no change in the CC of the toxic TCA at 1640 cm−1 in ALDH at different pHs. The conclusion of the study was that the CHO of the toxic TCA was intercepted by the Oxy‐Res under the action of ALDH in the mitochondria, particularly at pH 7.8. © 2019 IUBMB Life, 2019

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Section: Introductionmentioning

confidence: 99%

Toxic trans‐crotonaldehyde in mitochondria intercepted by oxyresveratrol contributing to anticancer

Sun

Chen

et al. 2019

IUBMB Life

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“…Some mulberry roots contain stilbenoids and polyphenols [3]. The stilbene and polyphenol derivatives in mulberry have been studied in leaves, branches, stems, and roots and occur in the highest concentration in roots [7].…”

Section: Introductionmentioning

confidence: 99%

In Vivo Analysis of the Effect of Nanostructured Lipid Carrier-Based Gel of Mulberry Root Extract Against Ultraviolet Light

2018

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Objective: This study aimed to analyze the in vivo anti-ultraviolet (UV) activity of nanostructured lipid carrier (NLC) of mulberry extract on six New Zealand rabbits.Methods: Mulberry roots were treated with 96% ethanol using a maceration-ultrasonication method, and the extract was transformed into NLCs using the solvent evaporation method. The NLC was characterized for particle size and polydispersity index and zeta potential. The morphology of nanoparticles was examined using transmission electron microscope and subsequently in the NLC-based gel preparation. The gel was evaluated in vivo for anti-UV activity on male rabbits in three treatment groups: Positive control, sample gel, and negative control (exposed to UV light for 6 h). The anti-UV activity was scored as a skin erythema response using Dermalab ® , and the results were analyzed using Kruskal-Wallis and Mann-Whitney methods. Results:The particle size, polydispersity index, and zeta potential of the NLC were quantified as 203.2 nm, 0.264, and −38.7 mV, respectively. The viscosity of the gel was 42,500 cps, with pseudoplastic thixotropic flow properties including the spreading ability, particle size 5156.81 mm, and pH 5.92, respectively. The anti-UV activity was determined as 0.22, 1.44, and 2.22 for the positive control, NLC-based gel, and negative control groups, respectively. Conclusion:The anti-UV activity of NLC-based gel of mulberry root extract was very small on areas where erythema had formed and differed significantly between the positive and negative control groups (p<0.05).

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“…The mulberry tree belongs to the genus Morus , and it has been widely cultivated in eastern Asia and used in herbal medicines (1) . Mulberry extracts contain large amounts of stilbenes, including oxyresveratrol (2,3’,4,5’-tetrahydroxy-trans-stilbene; OXY) (2) . OXY exhibits anti-oxidant, anti-hyperlipidemic and anti-inflammatory activities (3 - 5) .…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory action of ethanolic extract of Ramulus mori on the BLT2-linked cascade

Park

Kim

2016

BMB Reports

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Mulberry tree twigs (Ramulus mori) contain large amounts of oxyresveratrols and have traditionally been used as herbal medicines because of their anti-inflammatory properties. However, the signaling mechanism by which R. mori exerts its anti-inflammatory action remains to be elucidated. In this study, we observed that R. mori ethanol extracts (RME) exerted an inhibitory effect on the lipopolysaccharide (LPS)-induced production of the pro-inflammatory cytokine interleukin-6 (IL-6) in Raw264.7 macrophage cells. Additionally, RME inhibited IL-6 production by blocking the leukotriene B4 receptor-2 (BLT2)-dependent-NADPH oxidase 1 (NOX1)-reactive oxygen species (ROS) cascade, leading to anti-inflammatory activity. Finally, RME suppressed the production of the BLT2 ligands LTB4 and 12(S)-HETE by inhibiting the p38 kinase-cytosolic phospholipase A2-5-/12-lipoxygenase cascade in LPS-stimulated Raw264.7 cells. Overall, our results suggest that RME inhibits the ‘BLT2 ligand-BLT2’-linked autocrine inflammatory axis, and that this BLT2-linked cascade is one of the targets of the anti-inflammatory action of R. mori. [BMB Reports 2016; 49(4): 232-237]

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Variations in the Levels of Mulberroside A, Oxyresveratrol, and Resveratrol in Mulberries in Different Seasons and during Growth

Cited by 37 publications

References 16 publications

Toxic trans‐crotonaldehyde in mitochondria intercepted by oxyresveratrol contributing to anticancer

Toxic trans‐crotonaldehyde in mitochondria intercepted by oxyresveratrol contributing to anticancer

In Vivo Analysis of the Effect of Nanostructured Lipid Carrier-Based Gel of Mulberry Root Extract Against Ultraviolet Light

Anti-inflammatory action of ethanolic extract of Ramulus mori on the BLT2-linked cascade

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