To define the domains in the envelope glycoprotein important for antibody neutralization of the human immunodeficiency virus type 1 (HIV-1), monoclonal antibodies (mAbs) were generated by immunizing mice with purified glycoprotein gpl20 of the MB isolate. One mAb, G3-4, reacted with the gpl20 of homologous ('fB) and heterologous (RF) isolates. In addition, mAb G3-4 efficiently neutralized both
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