24(<i>S</i>)-Saringosterol from Edible Marine Seaweed <i>Sargassum fusiforme</i> Is a Novel Selective LXRβ Agonist

Chen, Zhe; Liu, Jiao; Fu, Zhifei; Cheng, Ya; Zhang, Renshuai; Song, Yiyun; Zhang, Ying; Li, Haihua; Ying, Hao; Liu, Hongbing

doi:10.1021/jf500083r

Cited by 85 publications

(77 citation statements)

References 34 publications

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“…Other bioactive algal metabolites isolated from non-polar extracts include cytotoxic, antibacterial linear sesquiterpenoids from the green alga Penicillus capitatus (class Ulvophyceae, order Bryopsidales) (Paul and Fenical 1984); antibacterial labdane diterpenoids from Ulva fasciata (Chakraborty et al 2010); and antiatherosclerotic phytosterols from the brown alga Sargassum fusiforme (order Fucules) (Chen et al 2014).…”

Section: Discussionmentioning

confidence: 99%

Selecting Australian marine macroalgae based on the fatty acid composition and anti-inflammatory activity

et al. 2014

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Increasingly, macroalgae are being recognised as a growth opportunity for functional foods and nutritional security in the future. Dominating traits of interest are metabolites that function as anti-inflammatories and are antiproliferative. However, seaweeds from the northern hemisphere dominate this field of research. Australia has a unique flora of macroalgae, and it is poorly understood which species should be targeted for cultivation towards food and health markets. Here, six Australian marine macroalgae were selected for screening of one anti-inflammatory group; n-3 polyunsaturated fatty acids (PUFA). PUFA profiles were determined using gas chromatography-mass spectrometry and multivariate analysis. Thirty-one fatty acids (FA) were identified across the six macroalgal species with C16:0 the dominant FA in all samples, variations across taxa in the saturated FA C10:0, C14:0, C16:0, C18:0 and C20:0 and variations in monounsaturated FA attributed to C16:1 n-7 and C18:1 n-9. For PUFA profiles, all six species had significantly different n-6/n-3 ratios, while the green seaweed Ulva species possessed the lowest n-6/n-3 ratio of 0.4, along with a 2-fold higher C18:3 n-3 to C18:2 n-6 content. Ulva sp. was the only species that contained docosahexaenoic acid. Extracts of both the Ulva sp. and Hormosira banksii showed selective cytotoxicity towards a human pancreatic cancer cell line, while the nonpolar extracts of all six algae species strongly inhibited production of the inflammatory-mediator nitric oxide. Abstract Increasingly macroalgae are being recognized as a growth opportunity for functional foods and nutritional security in the future. Dominating traits of interest are metabolites that function as anti-inflammatories and are antiproliferative. However seaweeds cultivated in the northern hemisphere dominate this field of research. Australia has a unique flora of macroalgae and it is poorly understood which species should be targeted for cultivation towards food and health markets. Herein, six Australian marine macroalgae were selected for screening of one antiinflammatory group; n-3 polyunsaturated fatty acids (PUFA). PUFA profiles were determined using gas chromatography -mass spectrometry and multivariate analysis. Thirty-one fatty acids (FA) were identified across the six macroalgal species with C16:0 the dominant FA in all samples, variations across taxa in the saturated FA C10:0, C14:0, C16:0, C18:0 and C20:0 and variations in monounsaturated FA attributed to C16:1 n-7 and C18:1 n-9. For PUFA profiles, all six species had significantly different n-6/n-3 ratios, while the green seaweed Ulva sp. possessed the lowest n-6/n-3 ratio of 0.4, along with a 2-fold higher C18:3 n-3 to C18:2 n-6 content. Ulva sp. was the only species that contained docosahexaenoic acid. Extracts of both the Ulva sp. and H. banksii showed selective cytotoxicity towards a human pancreatic cancer cell line, while the non-polar extracts of all six algal species strongly inhibited production of the inflammatory-mediator nitric ...

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Section: Discussionmentioning

confidence: 99%

Selecting Australian marine macroalgae based on the fatty acid composition and anti-inflammatory activity

et al. 2014

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“…[86], and sterols from Sargassum spp. have been shown to have potent natural cholesterol-lowering activity [87,88].…”

Section: Sterolsmentioning

confidence: 99%

Golden Tides: Problem or Golden Opportunity? The Valorisation of Sargassum from Beach Inundations

Milledge

Harvey

2016

JMSE

150

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Abstract:In recent years there have been massive inundations of pelagic Sargassum, known as golden tides, on the beaches of the Caribbean, Gulf of Mexico, and West Africa, causing considerable damage to the local economy and environment. Commercial exploration of this biomass for food, fuel, and pharmaceutical products could fund clean-up and offset the economic impact of these golden tides. This paper reviews the potential uses and obstacles for exploitation of pelagic Sargassum. Although Sargassum has considerable potential as a source of biochemicals, feed, food, fertiliser, and fuel, variable and undefined composition together with the possible presence of marine pollutants may make golden tides unsuitable for food, nutraceuticals, and pharmaceuticals and limit their use in feed and fertilisers. Discontinuous and unreliable supply of Sargassum also presents considerable challenges. Low-cost methods of preservation such as solar drying and ensiling may address the problem of discontinuity. The use of processes that can handle a variety of biological and waste feedstocks in addition to Sargassum is a solution to unreliable supply, and anaerobic digestion for the production of biogas is one such process. More research is needed to characterise golden tides and identify and develop commercial products and processes.

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“…Recent evidence from other Sargassum species (e.g. S. fusiforme) support this contention, with saringosterol showing potent natural cholesterol-lowering activity, with other sterols contributing to anti-atherosclerotic functions (Chen et al 2014b). A wide range of sterols (C16-C30) have been described in S. muticum, with C29 and C30 sterols accounting for 25 and 18 % of total sterols respectively (Wang et al 2006).…”

Section: Sterolsmentioning

confidence: 99%

High-value products from macroalgae: the potential uses of the invasive brown seaweed, Sargassum muticum

Milledge

Nielsen

Bailey³

2015

Rev Environ Sci Biotechnol

141

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Marine seaweeds represent an abundant source of natural products and may harbour valuable chemicals. The brown seaweed Sargassum muticum is an invasive species to the coasts of the British Isles, mainland Europe and North America. Attempts at its eradication and control have generally not been successful, although time-consuming and costly. Commercial exploration of this biomass for food, fuel and pharmaceutical products could encourage its harvesting and control. Though S. muticum might be unsuitable as a source of biofuel due to high ash and water content, this rapidly growing macroalga has a naturally high content of antioxidants, carotenoids and phenols, including the well-known anti-cancer compound fucoxanthin, making this species a potential source of a range of pharmaceutically relevant materials.

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24(S)-Saringosterol from Edible Marine Seaweed Sargassum fusiforme Is a Novel Selective LXRβ Agonist

Cited by 85 publications

References 34 publications

Selecting Australian marine macroalgae based on the fatty acid composition and anti-inflammatory activity

Selecting Australian marine macroalgae based on the fatty acid composition and anti-inflammatory activity

Golden Tides: Problem or Golden Opportunity? The Valorisation of Sargassum from Beach Inundations

High-value products from macroalgae: the potential uses of the invasive brown seaweed, Sargassum muticum

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