Abstract:Objectives: d opioids have been shown to confer ischemic preconditioning and pharmacologic ischemic preconditioning to the myocardium. However, their role in providing extended pharmacologic ischemic preconditioning in hemorrhagic shock has not been explored. The authors examined the effects of 24-hour preinfusions of a selective d opioid receptor agonist, Deltorphin-D variant (Delt-D var ), on hemodynamic stability and duration of survival in a rat model of severe hemorrhagic shock.Methods: Conscious Sprague-… Show more
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