Pretreatment With Fentanyl and Propofol Attenuates Myocardial Injury in Rabbits With Acute Hemorrhagic Shock

Yao, Linong; Kuai, Jianke; Liu, Xiaofeng; Yu, De‐Quan; Yang, Yonghui; Tao, Ling; Zeng, Xiaoli; Chai, Weidong

doi:10.1016/j.jss.2008.07.012

Cited by 10 publications

(5 citation statements)

References 22 publications

(23 reference statements)

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“…Fentanyl is an 80‐fold more potent synthetic derivative of morphine. As morphine, it has a higher affinity for the μ‐opioid receptor, but it also binds to the δ‐ and κ‐opioid receptors [9,10]. Tramadol is a synthetic derivative of codeine, which acts centrally and displays a low affinity for μ‐opioid receptors (6000‐fold less than morphine).…”

Section: Introductionmentioning

confidence: 99%

Opioid analgesics in experimental sepsis: effects on physiological, biochemical, and haemodynamic parameters

Nardi

Bet

Fernandes

et al. 2012

Fundamemntal Clinical Pharma

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Cecal ligation and puncture (CLP) is the sepsis model that more closely resembles the human pathology, but it is likely to cause suffering to experimental animals. However, it is not clear whether the use of analgesia may affect some parameters evaluated in experimental sepsis research. Therefore, we investigated the effects of fentanyl and tramadol in experimental sepsis in the rat. The following parameters were evaluated: body temperature, body weight, water and food ingestion, mortality, analgesia, blood leukocytes, mean arterial blood pressure, vascular reactivity to phenylephrine, lung myeloperoxidase activity, and plasma levels of IL1-β, glutamic-oxaloacetic, glutamic-pyruvic, lactate, creatinine and urea. While producing significant analgesia, the opioids modify minimally the parameters, with the exception of sepsis-induced hypotension and mortality. Although fentanyl and tramadol can minimize pain and the general suffering of animals submitted to CLP surgery, their effects on cardiovascular parameters as well as in the mortality indicate that their use in experimental sepsis must be done with caution and with all the proper control groups.

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Section: Introductionmentioning

confidence: 99%

Opioid analgesics in experimental sepsis: effects on physiological, biochemical, and haemodynamic parameters

Nardi

Bet

Fernandes

et al. 2012

Fundamemntal Clinical Pharma

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“…A rabbit model of hemorrhagic shock was established as described previously [ 11 , 12 ], with minor modifications. Briefly, animals were anesthetized via intramuscular injection of ketamine (21 mg/kg body weight) and xylazine (2.2 mg/kg body weight).…”

Section: Methodsmentioning

confidence: 99%

Evaluation of the Microcirculation in a Rabbit Hemorrhagic Shock Model Using Laser Doppler Imaging

et al. 2015

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The aim of this study is to evaluate the feasibility of Laser Doppler imaging (LDI) for noninvasive and dynamic assessment of hemorrhagic shock in a rabbit model. A rabbit model of hemorrhagic shock was generated and LDI of the microcirculation in the rabbit ears was performed before and at 0, 30, 60, and 90 min after hemorrhage. The CCD (Charge Coupled Device) image of the ears, the mean arterial pressure (MAP) and the heart rate (HR) were monitored. The mean LDI flux was calculated. The HR of rabbits was significantly (p < 0.05) elevated and the MAP was decreased after hemorrhage, compared to the pre-hemorrhage level. Within the initial 30 min after hemorrhage, the perfusion flux lineally dropped down. In contrast, the MAP values did not differ significantly between the time points of 0 and 30 after hemorrhage (p > 0.05). Both the flux numbers and the red-to-blue color changes on LDI imaging showed the reduction of the microcirculation. LDI imaging is a noninvasive and non-contact approach to evaluate the microcirculation and may offer benefits in the diagnosis and treatment of hemorrhage shock. Further studies are needed to confirm its effectiveness in clinical practice.

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“…All animals were housed in wire-bottomed cages at 24°C (room temperature) with a 12 h light : 12 h dark cycle and were fed standard chow and water. An animal model of haemorrhagic shock was then established in all animals using a modification of the method of Wiggers, described by Yao et al 10 Anaesthesia was maintained with ketamine (100 mg/kg) given intramuscularly every 90 min. After the right femoral artery and carotid artery had been cannulated, all rabbits were allowed to stabilize for 15 min and were then bled from the arterial catheter for 2 -3 min until 45% of the blood volume had been withdrawn.…”

Section: Animal Model Of Haemorrhagic Shockmentioning

confidence: 99%

Therapeutic Effects of Intravenous Infusion of Hyperoxygenated Solution on Acute Haemorrhagic Shock in Rabbits

Han²,

Gao

et al. 2011

J Int Med Res

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Tissue anoxia is the main mechanism of the shock reaction. Here, the effect of hyperoxygenated solution (HOS) on acute haemorrhagic shock was studied in rabbits. At 60 min after shock, rabbits were infused intravenously with hyperoxygenated solution at 10 (HOS1 group) or 20 ml/kg (HOS2 group) or with Ringer's solution at 10 ml/kg (RS group). Compared with values before shock, values after shock were lower for mean arterial pressure (MAP), more negative for base excess (BE) and higher for blood lactate (BL) and blood viscosity. After infusion, MAP declined more slowly in the HOS1 and HOS2 groups than in the RS group. At 30 and 60 min after infusion, arterial partial pressure of oxygen (PaO 2 ) and oxygen saturation (SaO 2 ) were higher and BE was less negative in the HOS1 and HOS2 groups than in the RS group, BL was lower in the HOS1 and HOS2 groups than in the RS group, and PaO 2 and SaO 2 were higher in the HOS2 group than in the HOS1 group. It was concluded that HOS infusion can rectify changes in vital signs more effectively than Ringer's solution after acute haemorrhagic shock in rabbits.

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Pretreatment With Fentanyl and Propofol Attenuates Myocardial Injury in Rabbits With Acute Hemorrhagic Shock

Cited by 10 publications

References 22 publications

Opioid analgesics in experimental sepsis: effects on physiological, biochemical, and haemodynamic parameters

Opioid analgesics in experimental sepsis: effects on physiological, biochemical, and haemodynamic parameters

Evaluation of the Microcirculation in a Rabbit Hemorrhagic Shock Model Using Laser Doppler Imaging

Therapeutic Effects of Intravenous Infusion of Hyperoxygenated Solution on Acute Haemorrhagic Shock in Rabbits

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