24-Hour Metabolic Rate in Insomniacs and Matched Normal Sleepers

Bonnet, Michael H.; Arand, Donna L.

doi:10.1093/sleep/18.7.581

Cited by 473 publications

(315 citation statements)

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“…The HPA axis plays a role in the glucose metabolism impairment observed in insomnia as determined by objective and subjective criteria 18 . Objective short sleep duration is associated with physiological hyper-arousal in insomnia patients 19,20 . Chronic stress system activity is related to increased cortisol levels 21 .…”

Section: Discussionmentioning

confidence: 99%

Objective short sleep duration is associated with the activity of the hypothalamic-pituitary-adrenal axis in insomnia

D’Aurea¹,

Poyares²,

Piovezan³

et al. 2015

Arq. Neuro-Psiquiatr.

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Objective To evaluate the association between objective short sleep duration in patients with insomnia and changes in blood parameters related to hypothalamic-pituitary-adrenal (HPA) axis activity.Method A cross-sectional pilot study was conducted in 30 middle-aged adults with chronic insomnia who were divided into 2 groups according to polysomnography (PSG) total sleep time (TST) (TST > 5h and < 5h). All patients underwent subjective analysis of sleep quality, anthropometric measurements, PSG, and determination off asting blood parameters.Results The results revealed lower sleep efficiency and higher sleep latency for those with a TST < 5h. The subjective sleep quality was worse in the TST < 5h. Significantly, higher glucose and cortisol levels were observed with a TST < 5h. Glucose, cortisol and ACTH levels were inversely correlated with the PSG total sleep time.Conclusion Patients with insomnia with objective short sleep duration had HPA-associated endocrine and metabolic imbalances chronically linked to increases in cardiovascular risk observed with this more severe insomnia phenotype.

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Section: Discussionmentioning

confidence: 99%

Objective short sleep duration is associated with the activity of the hypothalamic-pituitary-adrenal axis in insomnia

D’Aurea¹,

Poyares²,

Piovezan³

et al. 2015

Arq. Neuro-Psiquiatr.

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“…In support of this theory, insomniacs have been found to have an increased whole body metabolic rate when compared with normal sleepers (Bonnet & Arand, 1997;Stepanski et al, 1988). They also score higher than normal sleepers on a Hyperarousal Scale, and, even during the day when complaining of fatigue, insomniacs still take a longer time to fall asleep (Pavlova et al, 2001;Bonnet & Arand, 1995).…”

Section: Insomnia Pathogenesismentioning

confidence: 91%

Insomnia: Prevalence, Impact, Pathogenesis, Differential Diagnosis, and Evaluation

Mai

Buysse

2008

Sleep Medicine Clinics

238

153

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“…Th us, most studies have identifi ed hyperarousal by noting diff erences between insomnia and control groups, rather than denoting a specifi c threshold. 27 We propose hyperarousal as an overarching theme that, along with other contributory factors, enriches our understanding of the pathophysiology of insomnia at each level of analysis and across levels in an integrated model.…”

Section: Levels Of Analysis: An Approach To Understanding Insomniamentioning

confidence: 99%

The Pathophysiology of Insomnia

Levenson

Kay

Buysse

2015

Chest

253

147

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Insomnia disorder is characterized by chronic dissatisfaction with sleep quantity or quality that is associated with diffi culty falling asleep, frequent nighttime awakenings with diffi culty returning to sleep, and/or awakening earlier in the morning than desired. Although progress has been made in our understanding of the nature, etiology, and pathophysiology of insomnia, there is still no universally accepted model. Greater understanding of the pathophysiology of insomnia may provide important information regarding how, and under what conditions, the disorder develops and is maintained as well as potential targets for prevention and treatment.The aims of this report are (1) to summarize current knowledge on the pathophysiology of insomnia and (2) to present a model of the pathophysiology of insomnia that considers evidence from various domains of research. Working within several models of insomnia, evidence for the pathophysiology of the disorder is presented across levels of analysis, from genetic to molecular and cellular mechanisms, neural circuitry, physiologic mechanisms, sleep behavior, and self-report. We discuss the role of hyperarousal as an overarching theme that guides our conceptualization of insomnia. Finally, we propose a model of the pathophysiology of insomnia that integrates the various types of evidence presented.

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24-Hour Metabolic Rate in Insomniacs and Matched Normal Sleepers

Cited by 473 publications

References 0 publications

Objective short sleep duration is associated with the activity of the hypothalamic-pituitary-adrenal axis in insomnia

Objective short sleep duration is associated with the activity of the hypothalamic-pituitary-adrenal axis in insomnia

Insomnia: Prevalence, Impact, Pathogenesis, Differential Diagnosis, and Evaluation

The Pathophysiology of Insomnia

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