24-Hour Colonic Manometry in Pediatric Slow Transit Constipation shows Significant Reductions in Antegrade Propagation

Abstract

Prolonged pancolonic manometry in children with STC showed significant impairment in antegrade propagating motor activity and failure to respond to normal physiological stimuli. Despite this, HAPS occurred with normal frequency. These findings suggest significant clinical differences between STC in children and adults.

Daily transabdominal electrical stimulation at home increased defecation in children with slow-transit constipation: a pilot study

“…When the trial was designed, the optimal parameters (if any) were unknown, and hence were selected on arbitrary criteria. Having demonstrated a statistical improvement in transit times [7], 24-hour colonic manometry [11], and quality of life [6,10] in the trial, the current study aimed to find out whether more frequent TES treatment might further improve function.…”

Transanal rectosigmoid resection for severe intractable idiopathic constipation

“…Colonic manometry is used by many practitioners to evaluate idiopathic constipation [19,20]. Our experience with this modality demonstrated inconsistent results [4].…”

Characterization of motor patterns in isolated human colon: are there differences in patients with slow-transit constipation?

“…Interestingly, in the study of King and colleagues (11), it was identified that in children with STC there was a significant impairment in antegrade propagating activity, with no change in the frequency of high-amplitude propagating sequences. Also, King et al reported deficient or absent responses to physiological stimuli.…”

“…A number of studies have made attempts to identify mechanisms underlying the onset of STC, but no clear underlying mechanism has yet been determined. There is evidence that a population of patients with STC have reduced numbers of high-amplitude propagating contractions (2,11). There is also evidence that the interval between CMCs is reduced in the transverse colon and splenic flexure (9).…”