24-Hour Arterial Stiffness Profile in Patients With Chronic Obstructive Pulmonary Disease and Chronic Heart Failure

Borodkin, A. V.; Кароли, Н. А.; Ребров, А. П.

doi:10.17650/1818-8338-2015-9-3-40-45

Cited by 4 publications

(1 citation statement)

References 4 publications

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“…В свою очередь, присутствие АГ у пациента с ХОБЛ повышает вероятность смерти после госпитализаций по поводу обострения ХОБЛ [48,49]. Особенностью течения АГ при ХОБЛ является ее неблагоприятный суточный профиль с преобладанием повышения АД в ночном периоде (non-dippers, night-peakers) и высокой суточной вариабельностью [50,51], что, в свою очередь, является предиктором раннего ПОМ и развития ССО [15,50,52]. Соответственно, ранняя диагностика и своевременное лечение АГ и ХОБЛ являются актуальной задачей, решение которой направлено на снижение общей и сердечно-сосудистой смертности и увеличение продолжительности жизни пациентов с коморбидной патологией.…”

Section: эпидемиология сочетания аг и хоблunclassified

Clinical practice guidelines on the diagnosis and treatment of patients with arterial hypertension and chronic obstructive pulmonary disease

et al. 2020

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One of the most common comorbid condition in people over 40 years old is: arterial hypertension (AH) and chronic obstructive pulmonary disease (COPD). The frequency of AH in patients with COPD varies from 6.8 to 76.3%, in average 34.3%. COPD is detected in every fourth patient with hypertension in the age group of 2564 years. The current trend towards an increase in life expectancy and therefore growing pool of elder cohort, will lead to a higher number of patients with comorbid disorders. Diagnosis and treatment of AH and COPD are determined by current clinical recommendations for both nosologies, however, a number of mutual pathophysiological mechanisms lead to a more severe course of these diseases with frequent exacerbations. The choice of antihypertensive therapy in patients with AH in combination with COPD should be given to drugs that can provide an adequate decrease in blood pressure in hypoxic conditions, especially at night and early morning hours, that have prolonged effect or could be prescribed in the evening, and to those that dont worsen bronchial obstruction or exacerbate hypoxia. Patients with AH and COPD should be given recommendations on lifestyle changes, especially smoking cessation. As initial therapy calcium channel blockers, angiotensin receptor blockers or angiotensin-converting enzyme inhibitors should be considered. Calcium channel blockers/renin-angiotensin system blockers should be considered as the first line for combination therapy. Thiazide, thiazide-like diuretics orb1-selective adrenergic blockers could be prescribed in case of insufficient antihypertensive response or depending on different clinical scenarios. Bronchodilators are the baseline therapy in COPD with concomitant AH. According to modern concepts, prescription of combination therapy with different mechanisms of action is the most proven and justified approach, which leads to a decrease in the frequency of exacerbations of COPD and amelioration of the symptoms. The choice of bronchodilator in the case of a COPD and AH combination, should take into account the proven long-term safety regarding the risk of cardiovascular complications. Tiotropium bromide as the monotherapy, including as a liquid inhaler and aclidinium/formoterol, tiotropium/oladeterol as combination therapy showed cardiovascular safety in the long-term studies. The escalation of COPD therapy with the need of inhaled steroids requires careful monitoring of blood pressure and, possibly, a revision of antihypertensive treatment leading to its escalation as well. COPD has many phenotypes requiring different medications, eg.: roflumilast, theophylline, macrolides and mucoactive drugs, that could also require tighter blood pressure control on patients with COPD and AH.

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Section: эпидемиология сочетания аг и хоблunclassified

Clinical practice guidelines on the diagnosis and treatment of patients with arterial hypertension and chronic obstructive pulmonary disease

et al. 2020

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24-hour arterial stiffness monitoring in hypertensive and normotensive patients with bronchial asthma

Кароли

Zarmanbetova²,

Ребров

2022

Arter. gipertenz.

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Background. Cardiovascular disease is one of the major causes of death throughout the world. Early detection of target organ damage is important for more successful cardiovascular prevention and improvement of patient outcomes. Vascular wall is one of the target organs, and its damage is associated with the loss of elastic properties and increase in stiffness. The increased vascular stiffness is an independent predictor of cardiovascular risk. Objective. To evaluate parameters of the 24-hour arterial stiffness monitoring in hypertensive and normotensive patients with bronchial asthma. Design and methods. The study enrolled 100 patients with asthma. The control group included 30 healthy volunteers matched by gender and age. Each patient underwent ambulatory blood pressure and arterial stiffness monitoring using BPLab MnSDP-2 device (Petr Telegin, Russia). Results. Normotensive patients with asthma show higher values of arterial stiffness index and pulse wave velocity in the aorta in comparison with the control group. Comorbid patients with bronchial asthma and hypertension show the highest arterial stiffness. Conclusion. Patients with asthma with and without hypertension demonstrated significantly increased arterial stiffness in comparison with control group.

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The Clinical Significance of Evaluation Arterial Stiffness in Patients With Chronic Heart Failure and Chronic Obstructive Pulmonary Disease

Стаценко

Lopushkova

2022

Journal of Volgograd State Medical University

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The study demonstrates the clinical significance of evaluation arterial stiffness in association between level of oxygen saturation, indicators of respiratory function and left ventricular ejection fraction. An increase in the stiffness of the main arterial arteries and a higher activity of low-intensity chronic inflammation were reliably identified in patients with with chronic heart failure and chronic obstructive pulmonary disease in comparison with patients with isolated chronic heart failure. Statistically significant correlations were revealed between arterial stiffness and the level of oxygen saturation, left ventricular ejection fraction. Multiple regression analysis found a significant contribution of the main factors to arterial stiffness in patients with chronic heart failure and chronic obstructive pulmonary disease was established. These were the following factors – level of oxygen saturation, left ventricular ejection fraction and Tiffno's index.

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24-Hour Arterial Stiffness Profile in Patients With Chronic Obstructive Pulmonary Disease and Chronic Heart Failure

Cited by 4 publications

References 4 publications

Clinical practice guidelines on the diagnosis and treatment of patients with arterial hypertension and chronic obstructive pulmonary disease

Clinical practice guidelines on the diagnosis and treatment of patients with arterial hypertension and chronic obstructive pulmonary disease

24-hour arterial stiffness monitoring in hypertensive and normotensive patients with bronchial asthma

The Clinical Significance of Evaluation Arterial Stiffness in Patients With Chronic Heart Failure and Chronic Obstructive Pulmonary Disease

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