Salivary alpha-Amylase and Cortisol Responsiveness Following Electrical Stimulation Stress in Patients with the Generalized Type of Social Anxiety Disorder

Tamura, Akira; Maruyama, Yoshihiro; Ishitobi, Yoshinobu; Kawano, Aimi; Ando, Tomoko; Ikeda, Rie; Inoue, Ayako; Imanaga, Junko; Okamoto, Shizuko; Kanehisa, Masayuki; Ninomiya, Taiga; Tanaka, Yoshihiro; Tsuru, Jusen; Akiyoshi, Jotaro

doi:10.1055/s-0033-1353157

Cited by 17 publications

(35 citation statements)

References 17 publications

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“…We already reported that sAA in SAD patients displayed a significant higher level at baseline and a significantly larger response to electrical stimulation as compared to healthy controls (Tamura et al. 2013). This result is consistent with the results which in SAD there is a vulnerability of the autonomic nervous system more than the HPA axis (van Veen et al.…”

Section: Discussionmentioning

confidence: 99%

“…However, the results are not consistent with our past report in AVPD that there were no group differences in any HRV of SAD (Tamura et al. 2013) and low baseline HF represents a common index for inhibitory deficits across SAD (Pittig et al. 2013).…”

Section: Discussionmentioning

confidence: 99%

“…The present results are insistent with that in SAD (Tamura et al. 2013). STAI scores were significantly increased in AVP patients compared with controls.…”

Section: Discussionmentioning

confidence: 99%

“…The present results are insistent with that in SAD (Tamura et al. 2013). These results are also consist with borderline personality disorder, obsessive‐compulsive disorder, panic disorder, and MDD (Tanaka et al.…”

Section: Discussionmentioning

confidence: 99%

“…All participants were invited to our laboratory on a weekday afternoon between 1 and 5 p.m. (Ishitobi et al 2010;Maruyama et al, 2012;Tanaka et al 2012a,b;Kawano et al 2013;Tamura et al 2013;Tanaka et al 2013). The subjects wore stimulator coils on the right wrist; these coils were connected to a stimulator that provided an electrical current to the motor and sensory fibers of the median nerve.…”

Section: Electrical Stimulation Testmentioning

confidence: 99%

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Sex determines cortisol and alpha‐amylase responses to acute physical and psychosocial stress in patients with avoidant personality disorder

et al. 2016

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IntroductionsAvoidant personality disorder (AVPD) has excessive and pervasive anxiety and discomfort in social situations. The aims of this study were to explore the relationship between AVPD and physical and psychological stress and psychological tests.MethodsWe evaluated 93 AVPD patients and 355 nonpatient controls by salivary amylase and cortisol responses during exposure to the Trier Social Stress Test (TSST) and electrical stimulation stress. Spielberger state‐trait anxiety inventory (STAI), Profile of Mood State (POMS), Beck Depression Inventory (BDI), Depression and Anxiety Cognition Scale (DACS), and Childhood Trauma Questionnaire (CTQ) were administered.ResultsFollowing electrical stimulation, salivary cortisol levels in female AVPD decreased significantly less than that in female's controls, but salivary cortisol levels did not show a difference between male AVPD patients and controls. Salivary alpha‐amylase (sAA) levels did not show a difference between females or male AVPD patients and controls. Following TSST exposure, sAA levels did not show a difference between females or male AVPD patients and controls. Salivary cortisol levels did not show a difference between females or male AVPD patients and controls. In the AVPD patients, POMS scores were significantly higher compared with the controls. STAI, BDI, DACS scores, and CTQ significantly increased in the AVPD patients compared with the controls. LF in heart rate variability in AVPD significantly increased more compared with controls.ConclusionsThese results suggest that heightened sympathetic reactivity in female AVPD co‐occurs with attenuated salivary cortisol responses to electric stimulation stress and there is a significant difference between AVPD and controls in mood, anxiety, social cognition, and automatic nerve systems.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…The present results are insistent with that in SAD (Tamura et al. 2013). STAI scores were significantly increased in AVP patients compared with controls.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Electrical Stimulation Testmentioning

confidence: 99%

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Sex determines cortisol and alpha‐amylase responses to acute physical and psychosocial stress in patients with avoidant personality disorder

et al. 2016

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Physiological correlates of anxiety in childhood and adolescence: A systematic review and meta‐analysis

Ko,

Jones,

Francis

et al. 2024

Stress and Health

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Anxiety is one of the most prevalent problems that affects children and adolescents. The vast majority of diagnostic tools for anxiety depend on written or verbal reports from children and adolescents or their significant others. The validity and reliability of such reports can be compromised by their subjective nature. Thus, there is growing interest in whether anxiety can be indexed with objective physiological measures. The key aim of this systematic review and meta‐analysis was to determine which physiological measures are most reliably associated with elevated levels of anxiety amongst children and adolescents. Online databases (e.g., PsycINFO, Embase, Medline) were searched for relevant studies according to pre‐determined criteria. Twenty‐five studies comprising 2502 participants (N = 1160 with high anxiety) met inclusion, identifying 11 groups of physiological measures. Our meta‐analysis revealed that skin conductance level is the most sensitive measure of anxiety (d = 0.83), followed by electromyography (EMG) measures (d = 0.71) and skin conductance response (d = 0.58). However, the included studies varied in terms of subjective measures, study designs, experimental task measures, and physiological measures. Consideration of these differences in methodology offer potential directions for future research.

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Neurochemistry of Childhood Anxiety Disorders

Havel

Mehta

Gautam

et al. 2022

Handbook of Child and Adolescent Anxiety Disorders

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Salivary alpha-Amylase and Cortisol Responsiveness Following Electrical Stimulation Stress in Patients with the Generalized Type of Social Anxiety Disorder

Abstract: These results suggest that SAD patients displayed enhanced ANS (but not HPA axis) activity vs. healthy controls.

Cited by 17 publications

References 17 publications

Sex determines cortisol and alpha‐amylase responses to acute physical and psychosocial stress in patients with avoidant personality disorder

Sex determines cortisol and alpha‐amylase responses to acute physical and psychosocial stress in patients with avoidant personality disorder

Physiological correlates of anxiety in childhood and adolescence: A systematic review and meta‐analysis

Neurochemistry of Childhood Anxiety Disorders

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