Neurochemistry of Childhood Anxiety Disorders

Havel, Lauren; Mehta, Pranav; Gautam, Ankit; Danielyan, Edward; Saxena, Kirti

doi:10.1007/978-3-031-14080-8_5

Cited by 1 publication

(1 citation statement)

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“…6 These methods may entail C02 stimulating noradrenergic neural activity, according to a theory. 7 Carbon dioxide increases norepinephrine turnover and brain catecholamine synthesis in rats, as well as the rate at which neurons fire in the locus ceruleus noradrenergic nucleus of rats and "3-methoxy-4-hydroxyphenylglycol" levels in the plasma of rhesus monkeys, which is a metabolite of norepinephrine 8 Patients with PD always begin a description of their disorder by reporting symptoms related to breathing, the heart, the digestive tract and 'nerves. 9,10 Due to the somatic symptoms, 90% of patients with PD believe they have a physical condition instead of a mental disorder.…”

Section: Introductionmentioning

confidence: 99%

Carbon Dioxide – Induced Anxiety; Effects of Carbon Dioxide on Behavior, Physiology, and Biochemistry in Patients with Panic Disorders and Healthy Subjects.

Fazeelat Hajra Karim,

Muhammad Razaq,

Fouzia Qadir

et al. 2023

TPMJ

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Objective: To investigate the processes that make people with panic disorder more vulnerable to the anxiety brought on by exposure to carbon monoxide. Study Design: Randomized, Cross-over Design. Setting: Hayatabad Medical Complex and Khyber Girls Medical College. Period: April 2022 to December 2022. Material & Methods: Patients with anxiety-related conditions and volunteers in good health who underwent CO2 testing were included in the research. Various gas mixtures, including air, 5% CO2, and 7.5% CO2, were administered to participants in a random order. Behavioral measures, physiological parameters, and biochemical markers were assessed during and after CO2 inhalation. Results: Panic episodes were elicited in both patients with panic disorder and healthy controls by inhaling 5% CO2. Panic disorder patients experienced significantly higher anxiety, nervousness, dread, and sadness levels during 5% CO2 inhalation compared to healthy subjects. Physiological effects, such as increased pulse rate, contrasted those with panic disorder with those without it. No significant changes were seen in either group as a result of inhaling CO2 with respect to bloodstream levels of “free 3-methoxy-4-hydroxyphenylglycol, cortisol, growth hormone, or prolactin”. Conclusion: The inhaling of CO2 may trigger panic episodes and cause more intense behavioral and physicological reactions in those with panic disorder.

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Section: Introductionmentioning

confidence: 99%