“…In addition, the phenotypic and genotypic profiles are similar to cholangiolo cellular carcinoma, thought to originate from hepatic progenitor cells 17,50,51 . A number of observations suggest that bile ductular (mixed)-type iCCAs together with cholangiolocellular carcinoma and CK19 + HCC represent a group of primitive liver cancers originating from hepatic progenitor cells, the different phenotype depending on the step of hepatic progenitor cell differentiation toward cholangiocytes or hepatocytes, in which neoplastic transformation occurs 17,20,[52][53][54] .…”