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citations
Cited by 981 publications
(1,059 citation statements)
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References 309 publications
(428 reference statements)
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“…These effects may be of special relevance in areas of East-Asia with high HCV prevalence or countries where the diagnosis of primary tumors in livers with a cirrhotic background has been recently increasing [2].…”
Section: Additional Regulatory Factorsmentioning
confidence: 99%
See 1 more Smart Citation
“…These effects may be of special relevance in areas of East-Asia with high HCV prevalence or countries where the diagnosis of primary tumors in livers with a cirrhotic background has been recently increasing [2].…”
Section: Additional Regulatory Factorsmentioning
confidence: 99%
“…Cholangiocarcinoma (CCA) accounts for 3% of all gastrointestinal cancers and it is the second most common primary hepatic tumor after hepatocellular carcinoma [1,2]. CCA is composed of tumor cells exhibiting a phenotype of biliary epithelial cells, as well as nontumor cells, essentially myofibroblasts [3], and characterized by an aggressive behavior with early lymphatic and metastatic spread.…”
Section: Introductionmentioning
confidence: 99%
“…iCCAs, on the other hand, show two main histological subtypes-bile ductular type (mixed), and bile duct type (mucinous). 56 Chronic hepatitis B and hepatitis C infections are identified as a risk factors for CCA especially iCCA. 57 This type of CCA usually presents with mass-forming grown pattern (>90%) while infiltrative pattern is usually seen in pCCA and dCCA.…”
Section: Answers: B and Cmentioning
confidence: 99%
“…The incidence of CCA varies by geographic regions, ranging from 0.4-3.4 per 100,000 persons-year in North America and Europe to 1-85 per 100,000 persons-year in East Asia [1]. Although CCA is a relatively uncommon cancer, its incidence has been rising worldwide over the past decade [1].…”
Section: Introductionmentioning
confidence: 99%