Flavonoid intake and risk of CVD: a systematic review and meta-analysis of prospective cohort studies

Wang, Xia; Ouyang, Ying Y.; Li, Jun; Zhao, Gang

doi:10.1017/s000711451300278x

Cited by 329 publications

(236 citation statements)

References 66 publications

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“…On one hand, epidemiological studies have concluded that a high flavonoid intake benefits health (23,99) and certain lifespan studies in worms, flies and even mice show that flavonoids could promote longevity. On the other hand, the findings in mammalian model organisms are contradictory and health-related data on flavonoids in human subjects have been obtained from epidemiological Literature review of flavonoids and lifespan in model organisms…”

Section: Resultsmentioning

confidence: 99%

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A literature review of flavonoids and lifespan in model organisms

Pallauf¹,

Duckstein²,

Rimbach³

2016

Proc. Nutr. Soc.

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Epidemiological data on consumption of flavonoid-containing food points to the notion that some of these secondary plant metabolites may favour healthy ageing. The aim of the present paper was to review the literature on lifespan extension by flavonoids in worms, flies and mice. In most studies, worms and flies experienced lifespan extension when supplemented with flavonoids either as extracts or single compounds. Studies with mutant worms and flies give hints as to which gene products may be regulated by flavonoids and consequently enhance longevity. We discuss the data considering putative mechanisms that may underlie flavonoid action such as energy-restriction-like effects, inhibition of insulin-like-growth-factor signalling, induction of antioxidant defence mechanisms, hormesis as well as antimicrobial properties. However, it remains uncertain whether human lifespan could be prolonged by increased flavonoid intake.

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Section: Resultsmentioning

confidence: 99%

“…or sources (cocoa, tea) may differ in their potential to prevent disease (9,23) . Additionally, findings from the observational studies on mortality could result from other factors than flavonoid intake.…”

Section: Proceedings Of the Nutrition Societymentioning

confidence: 99%

A literature review of flavonoids and lifespan in model organisms

Pallauf¹,

Duckstein²,

Rimbach³

2016

Proc. Nutr. Soc.

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“…Dietary flavonoid intake has been reported to be protective against CVD in a number of cross-sectional and prospective cohort studies (72)(73)(74)(75). A recent meta-analysis examined the association between specific classes of flavonoid intake and CVD in prospective cohort studies (76) (76). Prospective cohort studies are useful for studying the effects of specific dietary components on long-term disease risk.…”

Section: Flavonoids As Atheroprotective Components Of the Dietmentioning

confidence: 99%

Effects of Dietary Flavonoids on Reverse Cholesterol Transport, HDL Metabolism, and HDL function

Millar

Duclos

Blesso

2017

Advances in Nutrition

147

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Strong experimental evidence confirms that HDL directly alleviates atherosclerosis. HDL particles display diverse atheroprotective functions in reverse cholesterol transport (RCT), antioxidant, anti-inflammatory, and antiapoptotic processes. In certain inflammatory disease states, however, HDL particles may become dysfunctional and proatherogenic. Flavonoids show the potential to improve HDL function through their welldocumented effects on cellular antioxidant status and inflammation. The aim of this review is to summarize the basic science and clinical research examining the effects of dietary flavonoids on RCT and HDL function. Based on preclinical studies that used cell culture and rodent models, it appears that many flavonoids (e.g., anthocyanidins, flavonols, and flavone subclasses) influence RCT and HDL function beyond simple HDL cholesterol concentration by regulating cellular cholesterol efflux from macrophages and hepatic paraoxonase 1 expression and activity. In clinical studies, dietary anthocyanin intake is associated with beneficial changes in serum biomarkers related to HDL function in a variety of human populations (e.g., in those who are hyperlipidemic, hypertensive, or diabetic), including increased HDL cholesterol concentration, as well as HDL antioxidant and cholesterol efflux capacities. However, clinical research on HDL functionality is lacking for some flavonoid subclasses (e.g., flavanols, flavones, flavanones, and isoflavones). Although there has been a tremendous effort to develop HDL-targeted drug therapies, more research is warranted on how the intake of foods or specific nutrients affects HDL function. Adv Nutr 2017;8:226-39.

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“…According to 'Phenol-Explorer' (an online database of polyphenols present in food) different citrus fruits, onions, broccoli, tea, grapefruit, Cocoa beans, red wine are rich in flavonols [8][9][10] . Different metaanalysis suggests, human should intake polyphenols in their daily dietary food for these essential surrogate nutrients for next generation survival 11,12 .…”

Section: Introductionmentioning

confidence: 99%

Isolation and Characterization of Flavonoid Compound Extracted Cardanthera Difformis Druce and Study of Its Antibacterial and Antioxidant Activities in Vitro

De¹,

Das²,

Mandal³

2017

Int. Res. J. Pharm.

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AB STR ACTHuman beings have been utilizing plants for basic preventive and curative health care since time immemorial. Medicinal plants have been used to treat illness and disease for thousands of years. Even now they are economically important, being used in the pharmaceutical, cosmetic, perfumery, and food industries. Screening of medicinal plants for antimicrobial activities and phytochemicals is important for finding potential new compounds for therapeutic use. Humans are now struggling for their existence against different oxidative stress related diseases. Different meta-analysis suggests that poly-phenols, especially flavonoids, may play best protective role against this epidemiology. In this paper, an attempt has been made to present the results of the experimental studies carried out to characterize a flavonoid compound that has been isolated and primarily identified from a plant extract of Cardanthera difformis Druce. The compound has similar physiochemical properties like quercetin. Antibacterial activity of extracted flavonoid has been carried out against various types of bacterial human pathogens. The result shows that the extract of Cardanthera difformis has a good anti-bacterial activity against Salmonella typhi. It has been found that this anti-bacterial flavonoid compound is good anti-oxidant compound and the anti-oxidant potentiality of the same has been quantified by DPPH-spectrophotometric assay.

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Flavonoid intake and risk of CVD: a systematic review and meta-analysis of prospective cohort studies

Cited by 329 publications

References 66 publications

A literature review of flavonoids and lifespan in model organisms

A literature review of flavonoids and lifespan in model organisms

Effects of Dietary Flavonoids on Reverse Cholesterol Transport, HDL Metabolism, and HDL function

Isolation and Characterization of Flavonoid Compound Extracted Cardanthera Difformis Druce and Study of Its Antibacterial and Antioxidant Activities in Vitro

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