Successful Hypothermia Treatment of Hypoxic-Ischemic Encephalopathy in a Neonate with Epidermolysis Bullosa

Karadağ, Nilgün; Beken, Serdar; Díllí, Dílek; Zencıroğlu, Ayşegül; Okumuş, Nurullah

doi:10.1007/s12098-013-1182-9

Cited by 2 publications

(3 citation statements)

References 5 publications

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“…Statistics indicate 18–20 million live neonates, and the occurrence rate of HIE as ~3–6‰ of live neonates, 15–20% of whom die at the neonatal period, while different types and degrees of long-term sequelae are present in 25–30% of survivals. Thus, this disease affects the quality of life of children ( 2 ). At present, the diagnosis of HIBD has been primarily based on medical history, clinical manifestation, blood gas analysis and imageological examination.…”

Section: Discussionmentioning

confidence: 99%

“…HIBD often occurs within 24 h after birth, and the occurrence rate of hypoxic ischemic encephalopathy (HIE) in neonates is 3–6‰ of live births. There are different types and different degrees of long-term sequelae in 25–30% of live births, which is the important disease that affects the life quality of children ( 2 ). The diagnosis is based on consciousness, muscular tension, change of primitive reflex, convulsion, disease course and prognosis.…”

Section: Introductionmentioning

confidence: 99%

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Clinical significance of elevated serum A-FABP and free fatty acid in neonates with hypoxic ischemic brain damage

Lian

Zhang

et al. 2016

Experimental and Therapeutic Medicine

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The main function of adipocyte fatty acid-binding protein (A-FABP) is to regulate fatty acid metabolism as its molecular chaperone. The clinical significance of A-FABP in hypoxic-ischemic brain damage (HIBD) neonates is not yet clear. Free fatty acid (FFA) in cerebral cortex increases along with hypoxia ischemia degree. Thus, we aimed to investigate whether FFA can induce A-FABP expression and elevate the serum A-FABP level in HIBD neonates. In the present study, 42 HIBD neonates were selected including 11 cases as mild, 16 cases as moderate and 15 cases as severe. The serum was collected from peripheral vein at 72 h after the first visit (acute stage) and 7 days after birth (recovery stage), and the serum from 10 normal neonates was used as the control. The serum level of A-FABP and FFA in 42 neonates with acute phase and recovery phase HIBD were detected using ELISA and copper colorimetric method. The overall serum A-FABP content in HIBD neonates at the acute stage was significantly higher compared to the normal neonates (P<0.05). The serum A-FABP level in severe HIBD neonates was significantly higher than that in mild HIBD, moderate HIBD and normal neonates (P<0.05). The serum FFA level in HIBD neonates at the acute stage was 1,521.57±605.63 µmol/l, which was significantly higher than that in the normal neonates 838.24±294.22 µmol/l. The serum FFA levels in mild, moderate and severe HIBD neonates were significantly higher than those in the normal neonates. The overall A-FABP level in HIBD neonates at the recovery stage was significantly lower compared to the acute stage, which was significant in severe HIBD neonates. A-FABP levels in mild and moderate HIBD neonates at recovery stage were decreased compared with the acute stage, although there was no statistical difference. There was a positive correlation between serum A-FABP and FFA in HIBD neonates at acute stage (r=0.369, P<0.05). In conclusion, serum A-FABP and FFA levels were signifcantly increased in HIBD neonates at acute stage, and were positively correlated. The serum A-FABP level in HIBD neonates at recovery stage was significantly lower than that in the acute stage. The results suggested that serum A-FABP and FFA levels at acute stage can reflect the severity of HIBD. The detection of serum A-FABP and FFA can be applied as indicators for the early diagnosis of HIBD, but also provides a basis for the clinical evaluation of HIBD treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical significance of elevated serum A-FABP and free fatty acid in neonates with hypoxic ischemic brain damage

Lian

Zhang

et al. 2016

Experimental and Therapeutic Medicine

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“…Yet the translation of this research into clinical practice has been associated with significant debate and controversy . Individual centres experiences of implementing TH in clinical practice have now been published …”

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confidence: 99%

Eligibility criteria for therapeutic hypothermia: From trials to clinical practice

Mehta

Joshi

Bajuk

et al. 2016

J Paediatrics Child Health

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Successful Hypothermia Treatment of Hypoxic-Ischemic Encephalopathy in a Neonate with Epidermolysis Bullosa

Cited by 2 publications

References 5 publications

Clinical significance of elevated serum A-FABP and free fatty acid in neonates with hypoxic ischemic brain damage

Clinical significance of elevated serum A-FABP and free fatty acid in neonates with hypoxic ischemic brain damage

Eligibility criteria for therapeutic hypothermia: From trials to clinical practice

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