Labeling of human hepatocellular carcinoma cells by hexamethylene diamine modified fluorescent carbon dots

Dong, Wei; Yan, Dong; Wang, Ying; Zhou, Shiqi; Ge, Xin; Sui, Lili; Wang, Jingwen

doi:10.1016/j.saa.2013.07.012

Cited by 13 publications

(4 citation statements)

References 26 publications

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“…The quantum yield of the synthesized o-PD-CDs, measured using fluorescent standard, was found to be 8%, comparable to or even higher than the values reported in literature for passivation of CDs with small diamines 9,26 . Time-resolved PL curves for o-PD-CDs and o-PD 0 measured at 375 nm excitation are presented in Figure 6, while the obtained PL lifetime values are listed in Table 1.…”

Section: Steady State and Time -Resolved Fluorescence Measurementssupporting

confidence: 80%

Surface passivation of carbon nanoparticles with 1,2-phenylenediamine towards photoluminescent carbon dots

Diac¹,

CRACIUN²,

MIHALACHE³

et al. 2020

Rev.Roum.Chim.

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The chemistry of carbon dots (CDs) surface has enabled the development of new luminescent nanomaterials with wide and precise array of applications. In respect to this, we perform the surface passivation of carboxylated carbon nanoparticles with the aromatic 1,2-phenylenediamine to prepare water-soluble photoluminescent CDs exhibiting a photoluminescence (PL) quantum yield of 8% at 575 nm, a composite photoluminescence signal in the 330-500 nm domain, and an average lifetime of 1.93 ns. This new synthetic strategy promoted the formation of carbon dots covered with benzimidazole-containing oligomers of 1,2-phenylenediamine (o-PD) that, by taking advantage of the benzimidazole derivatives' biological activity and their application in Material Science, could lead to various new applications.

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Section: Steady State and Time -Resolved Fluorescence Measurementssupporting

confidence: 80%

Surface passivation of carbon nanoparticles with 1,2-phenylenediamine towards photoluminescent carbon dots

Diac¹,

CRACIUN²,

MIHALACHE³

et al. 2020

Rev.Roum.Chim.

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“…Without heavy metals, they are far less toxic than semiconductor quantum dots 10,12 . In addition, the CDs are high-efficiency vehicles for some compounds or ions which may enable CDs extra functions due to their abundant surface groups 13,14 .…”

Section: Introductionmentioning

confidence: 99%

“…10,12 In addition, the CDs are high-efficiency vehicles for some compounds or ions which may provide CDs with extra applications due to their abundant surface groups. 13,14 Unlike uorescence imaging, magnetic resonance imaging (MRI) has been used in clinics for a long time. It is a noninvasive diagnostic method with high resolution of so tissue.…”

Section: Introductionmentioning

confidence: 99%

One-pot synthesis of gadolinium(iii) doped carbon dots for fluorescence/magnetic resonance bimodal imaging

et al. 2015

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One-pot synthesis of gadolinium (III) doped carbon dots using a facile hydrothermal approach was conducted for fluorescence/magnetic resonance bimodal imaging.A combination of fluorescence and magnetic resonance imaging (MRI) can provide high-resolution macroscopical anatomical information and high-sensitive microscopical optical signal simultaneously. In this work, harmless gadolinium (III) doped carbon dots are synthesized in a convenient one-pot hydrothermal approach and used for fluorescence / magnetic resonance multimodal imaging. Unlike typical carbon dots, TEM analysis shows that the carbon dots are particles with irregular shape. Furthermore, Fourier-transform infrared (FTIR) spectra demonstrated structural difference between gadolinium-undoped and doped carbon dots. Nonetheless, the gadolinium-doped carbon dots exhibit strong and stable fluorescence with excitation-dependent emission behavior. Moreover, as a MRI contrast agent, the gadolinium-doped carbon dots represent considerable magnetic resonance property with a longitudinal relaxation rate of 14.08 mM -1 s -1 . In addition, cytotoxicity study reveals that the gadolinium-doped carbon dots show very low toxicity to NCI-H446 cells with an IC50 value of 6.28 mg/ml. Direct application in cell labeling and in vivo MRI suggests that the gadolinium-doped carbon dots are dual functional fluorescent / MRI probes with excellent biocompatibility.

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“…Their study indicated that CD probes were possible ideal uorescence probes with excellent photostability and biocompatibility for cancer cell imaging. 82 CDs have good biocompatibility and low toxicity, but its uorescence signal is oen relatively weak. Yin and his assistants prepared nitrogen-doped CDs, which exist in a core-shell structure.…”

Section: Cds With Nontoxicitymentioning

confidence: 99%

The advances in applying inorganic fluorescent nanomaterials for the detection of hepatocellular carcinoma and other cancers

et al. 2015

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Labeling of human hepatocellular carcinoma cells by hexamethylene diamine modified fluorescent carbon dots

Cited by 13 publications

References 26 publications

Surface passivation of carbon nanoparticles with 1,2-phenylenediamine towards photoluminescent carbon dots

Surface passivation of carbon nanoparticles with 1,2-phenylenediamine towards photoluminescent carbon dots

One-pot synthesis of gadolinium(iii) doped carbon dots for fluorescence/magnetic resonance bimodal imaging

The advances in applying inorganic fluorescent nanomaterials for the detection of hepatocellular carcinoma and other cancers

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